caa a22 4500 445315113 CHVBK 20180317142644.0 cr unu---uuuuu 170323e20111201xx s 000 0 eng 10.1007/s10552-011-9845-1 doi (NATIONALLICENCE)springer-10.1007/s10552-011-9845-1 Patterns of meat intake and risk of prostate cancer among African-Americans in a large prospective study [Elektronische Daten] [Jacqueline Major, Amanda Cross, Joanne Watters, Albert Hollenbeck, Barry Graubard, Rashmi Sinha] Objective: Given the large racial differences in prostate cancer risk, further investigation of diet and prostate cancer is warranted among high-risk groups. The purpose of this study was to examine the association between type of meat intake and prostate cancer risk among African-American men. Methods: In the large, prospective NIH-AARP Diet and Health Study, we analyzed baseline (1995-1996) data from African-American participants, aged 50-71years. Incident prostate cancer cases (n=1,089) were identified through 2006. Dietary and risk factor data were ascertained by questionnaires administered at baseline. Cox models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) within intake quantiles. Results: Neither white nor processed meat intake was associated with prostate cancer, regardless of meat-cooking method. Red meats cooked at high temperatures were associated with an increased risk of prostate cancer (HR=1.18, 95% CI=1.00-1.38 and HR=1.22, 95% CI=1.03-1.44, for the upper two intake tertiles). Intake of the heterocyclic amine (HCA), 2-amino-3,4,8-trimethylimidazo[4,5-f] quinoxaline (DiMeIQx) was positively associated with prostate cancer (HR=1.30; 95% CI=1.05-1.61, p=0.02). No associations were observed for intake of other HCAs. Conclusion: Red meats cooked at high temperatures were positively associated with prostate cancer risk among African-American men. Further studies are needed to replicate these findings. Springer Science+Business Media B.V. (outside the USA), 2011 Prostate cancer nationallicence Cohort studies nationallicence Diet nationallicence Meat consumption nationallicence Racial disparities nationallicence Men nationallicence Major Jacqueline Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, 6120 Executive Boulevard, 20852, Rockville, MD, USA aut Cross Amanda Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, 6120 Executive Boulevard, 20852, Rockville, MD, USA aut Watters Joanne Division of Cancer Control and Population Sciences, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, 6120 Executive Boulevard, 20852, Rockville, MD, USA aut Hollenbeck Albert AARP, 20049, Washington, DC, USA aut Graubard Barry Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, 6120 Executive Boulevard, 20852, Rockville, MD, USA aut Sinha Rashmi Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, 6120 Executive Boulevard, 20852, Rockville, MD, USA aut Cancer Causes & Control Springer Netherlands 22/12(2011-12-01), 1691-1698 0957-5243 22:12<1691 2011 22 10552 https://doi.org/10.1007/s10552-011-9845-1 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10552-011-9845-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Major Jacqueline Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, 6120 Executive Boulevard, 20852, Rockville, MD, USA aut NATIONALLICENCE 700 1- Cross Amanda Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, 6120 Executive Boulevard, 20852, Rockville, MD, USA aut NATIONALLICENCE 700 1- Watters Joanne Division of Cancer Control and Population Sciences, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, 6120 Executive Boulevard, 20852, Rockville, MD, USA aut NATIONALLICENCE 700 1- Hollenbeck Albert AARP, 20049, Washington, DC, USA aut NATIONALLICENCE 700 1- Graubard Barry Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, 6120 Executive Boulevard, 20852, Rockville, MD, USA aut NATIONALLICENCE 700 1- Sinha Rashmi Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, 6120 Executive Boulevard, 20852, Rockville, MD, USA aut NATIONALLICENCE 773 0- Cancer Causes & Control Springer Netherlands 22/12(2011-12-01), 1691-1698 0957-5243 22:12<1691 2011 22 10552 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer