caa a22 4500 44531513X CHVBK 20180317142644.0 cr unu---uuuuu 170323e20111201xx s 000 0 eng 10.1007/s10552-011-9841-5 doi (NATIONALLICENCE)springer-10.1007/s10552-011-9841-5 Timing and intensity of recreational physical activity and the risk of subsite-specific colorectal cancer [Elektronische Daten] [Terry Boyle, Jane Heyworth, Fiona Bull, Sarah McKerracher, Cameron Platell, Lin Fritschi] Purpose: Although there is convincing evidence that physical activity reduces colon cancer risk, there are important questions that remain unanswered about the association. These include the timing and intensity of activity required to optimally reduce risk, and whether physical activity has a different effect on cancers at different sites within the colon. We conducted a case-control study to investigate these issues. Methods: A case-control study of colorectal cancer was conducted in Western Australia in 2005-2007. Data were collected on various risk factors. The estimated effects of recreational physical activity on the risk of cancers of the distal colon, proximal colon, and rectum were analyzed using multinomial logistic regression. This analysis included 870 cases and 996 controls. Results: The risk of distal colon cancer was reduced by performing a high level of vigorous-intensity activity between the ages 19 and 34years (women), 35 and 50years (men), after the age of 51years (men and women), and consistently over the adult lifetime (men and women). The risk of rectal cancer was reduced by performing a high level of vigorous activity between the ages 35 and 50years (men), and consistently over the adult lifetime (men). Proximal colon cancer risk was not associated with physical activity in any of the age periods or over the adult lifetime. Moderate intensity activity did not reduce the risk of colorectal cancer. Conclusion: Physical activity may have a greater effect on the risk of distal colon cancer than proximal colon cancer. Vigorous physical activity is required to reduce colorectal cancer risk. Springer Science+Business Media B.V., 2011 Colon cancer nationallicence Rectal cancer nationallicence Physical activity nationallicence Case control studies nationallicence AOR : Adjusted odds ratio nationallicence CI : Confidence interval nationallicence MET : Metabolic equivalent nationallicence Boyle Terry School of Population Health, The University of Western Australia, Perth, WA, Australia aut Heyworth Jane School of Population Health, The University of Western Australia, Perth, WA, Australia aut Bull Fiona School of Population Health, The University of Western Australia, Perth, WA, Australia aut McKerracher Sarah School of Population Health, The University of Western Australia, Perth, WA, Australia aut Platell Cameron School of Surgery, The University of Western Australia, Perth, WA, Australia aut Fritschi Lin Western Australian Institute for Medical Research, The University of Western Australia, B Block, Hospital Avenue, Sir Charles Gairdner Hospital, Nedlands, 6009, Perth, WA, Australia aut Cancer Causes & Control Springer Netherlands 22/12(2011-12-01), 1647-1658 0957-5243 22:12<1647 2011 22 10552 https://doi.org/10.1007/s10552-011-9841-5 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10552-011-9841-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Boyle Terry School of Population Health, The University of Western Australia, Perth, WA, Australia aut NATIONALLICENCE 700 1- Heyworth Jane School of Population Health, The University of Western Australia, Perth, WA, Australia aut NATIONALLICENCE 700 1- Bull Fiona School of Population Health, The University of Western Australia, Perth, WA, Australia aut NATIONALLICENCE 700 1- McKerracher Sarah School of Population Health, The University of Western Australia, Perth, WA, Australia aut NATIONALLICENCE 700 1- Platell Cameron School of Surgery, The University of Western Australia, Perth, WA, Australia aut NATIONALLICENCE 700 1- Fritschi Lin Western Australian Institute for Medical Research, The University of Western Australia, B Block, Hospital Avenue, Sir Charles Gairdner Hospital, Nedlands, 6009, Perth, WA, Australia aut NATIONALLICENCE 773 0- Cancer Causes & Control Springer Netherlands 22/12(2011-12-01), 1647-1658 0957-5243 22:12<1647 2011 22 10552 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer