caa a22 4500 445315156 CHVBK 20180317142644.0 cr unu---uuuuu 170323e20111201xx s 000 0 eng 10.1007/s10552-011-9838-0 doi (NATIONALLICENCE)springer-10.1007/s10552-011-9838-0 Fruit and vegetable consumption is inversely associated with having pancreatic cancer [Elektronische Daten] [Rick Jansen, Dennis Robinson, Rachael Stolzenberg-Solomon, William Bamlet, Mariza de Andrade, Ann Oberg, Traci Hammer, Kari Rabe, Kristin Anderson, Janet Olson, Rashmi Sinha, Gloria Petersen] Objective: Studies on fruit, vegetable, fiber, and grain consumption and pancreatic cancer risk are inconclusive. We used a clinic-based case-control study specifically designed to address limitations of both cohort and case-control studies to examine the relationship. Methods: Participants were excluded who reported changing their diet within 5years prior to study entry. And 384 rapidly ascertained cases and 983 controls (frequency matched on age (±5years), race, sex, and residence) completed epidemiologic surveys and 144-item food frequency questionnaires. Odds ratios (OR) and 95% confidence intervals were calculated using logistic regression adjusted for age, sex, smoking, body mass index, energy intake, and alcohol consumption. Results: Comparing highest to lowest quintiles, we observed significant inverse associations (OR<0.8) with significant trends (p trend<0.05) for citrus, melon, and berries, other fruits, dark green vegetables, deep yellow vegetables, tomato, other vegetables, dry bean and pea, insoluble fiber, soluble fiber, whole grains, and orange/grapefruit juice, and an increased association with non-whole grains. Results were similar after adjusting for diabetes or total sugar intake. Conclusions: We provide evidence that lower consumption of fruits, vegetables, whole grains, and fiber is associated with having pancreatic cancer. This may have a role in developing prevention strategies. Springer Science+Business Media B.V., 2011 Diet nationallicence Risk nationallicence Questionnaire nationallicence Pancreatic cancer nationallicence BMI : Body mass index nationallicence CI : Confidence interval nationallicence DM : Type 2 diabetes mellitus nationallicence FFQ : Food frequency questionnaire nationallicence NCI : National Cancer Institute nationallicence OR : Odds ratios nationallicence p trend : p-value from test for trend nationallicence WCRF/AICR : World Cancer Research Fund/American Institute for Cancer Research nationallicence Jansen Rick Department of Health Sciences Research, Mayo Clinic, 200 First Street SW, 55905, Rochester, MN, USA aut Robinson Dennis Department of Health Sciences Research, Mayo Clinic, 200 First Street SW, 55905, Rochester, MN, USA aut Stolzenberg-Solomon Rachael Department of Epidemiology, National Institutes of Health, Bethesda, MD, USA aut Bamlet William Department of Health Sciences Research, Mayo Clinic, 200 First Street SW, 55905, Rochester, MN, USA aut de Andrade Mariza Department of Health Sciences Research, Mayo Clinic, 200 First Street SW, 55905, Rochester, MN, USA aut Oberg Ann Department of Health Sciences Research, Mayo Clinic, 200 First Street SW, 55905, Rochester, MN, USA aut Hammer Traci Department of Health Sciences Research, Mayo Clinic, 200 First Street SW, 55905, Rochester, MN, USA aut Rabe Kari Department of Health Sciences Research, Mayo Clinic, 200 First Street SW, 55905, Rochester, MN, USA aut Anderson Kristin Department of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN, USA aut Olson Janet Department of Health Sciences Research, Mayo Clinic, 200 First Street SW, 55905, Rochester, MN, USA aut Sinha Rashmi Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA aut Petersen Gloria Department of Health Sciences Research, Mayo Clinic, 200 First Street SW, 55905, Rochester, MN, USA aut Cancer Causes & Control Springer Netherlands 22/12(2011-12-01), 1613-1625 0957-5243 22:12<1613 2011 22 10552 https://doi.org/10.1007/s10552-011-9838-0 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10552-011-9838-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Jansen Rick Department of Health Sciences Research, Mayo Clinic, 200 First Street SW, 55905, Rochester, MN, USA aut NATIONALLICENCE 700 1- Robinson Dennis Department of Health Sciences Research, Mayo Clinic, 200 First Street SW, 55905, Rochester, MN, USA aut NATIONALLICENCE 700 1- Stolzenberg-Solomon Rachael Department of Epidemiology, National Institutes of Health, Bethesda, MD, USA aut NATIONALLICENCE 700 1- Bamlet William Department of Health Sciences Research, Mayo Clinic, 200 First Street SW, 55905, Rochester, MN, USA aut NATIONALLICENCE 700 1- de Andrade Mariza Department of Health Sciences Research, Mayo Clinic, 200 First Street SW, 55905, Rochester, MN, USA aut NATIONALLICENCE 700 1- Oberg Ann Department of Health Sciences Research, Mayo Clinic, 200 First Street SW, 55905, Rochester, MN, USA aut NATIONALLICENCE 700 1- Hammer Traci Department of Health Sciences Research, Mayo Clinic, 200 First Street SW, 55905, Rochester, MN, USA aut NATIONALLICENCE 700 1- Rabe Kari Department of Health Sciences Research, Mayo Clinic, 200 First Street SW, 55905, Rochester, MN, USA aut NATIONALLICENCE 700 1- Anderson Kristin Department of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN, USA aut NATIONALLICENCE 700 1- Olson Janet Department of Health Sciences Research, Mayo Clinic, 200 First Street SW, 55905, Rochester, MN, USA aut NATIONALLICENCE 700 1- Sinha Rashmi Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA aut NATIONALLICENCE 700 1- Petersen Gloria Department of Health Sciences Research, Mayo Clinic, 200 First Street SW, 55905, Rochester, MN, USA aut NATIONALLICENCE 773 0- Cancer Causes & Control Springer Netherlands 22/12(2011-12-01), 1613-1625 0957-5243 22:12<1613 2011 22 10552 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer