caa a22 4500 445315172 CHVBK 20180317142644.0 cr unu---uuuuu 170323e20111201xx s 000 0 eng 10.1007/s10552-011-9837-1 doi (NATIONALLICENCE)springer-10.1007/s10552-011-9837-1 Angiotensin converting enzyme inhibitors and hepatocellular carcinoma incidence in the General Practice Research Database [Elektronische Daten] [Alex Walker, Joe West, Matthew Grainge, Tim Card] Objective: Laboratory findings demonstrate anticancer effects of angiotensin converting enzyme (ACE) inhibitors, including anti-angiogenic activity and inhibition of liver cancer growth in rodent models. Small studies in humans indicate potential for therapeutic anticancer effects and warrant further larger studies. Methods: A case-control study using the General Practice Research Database examined whether prior ACE inhibitor usage was associated with a reduction in incidence of hepatocellular carcinoma (HCC). Results: Two hundred twenty-four HCC cases were identified, each matched to up to 10 controls by age, sex, and general practice. The data show that HCC is associated with a small, nonsignificant increase in prior use of ACE inhibitors (OR=1.16, CI=0.67-2.00). ACE inhibitor use was 7.1% (of 224) in cases and 5.9% (of 2,313) in controls. No significant effects were found when investigating the effect of dose and exposure duration. Conclusions: We found no clear protective effect of ever or long term use of ACE inhibitors against the development of HCC. Our study suggests that it is unlikely that this class of drugs will be a clinically useful cancer chemoprevention therapy. Springer Science+Business Media B.V., 2011 ACE inhibitors nationallicence Hepatocellular carcinoma nationallicence Cancer incidence nationallicence GPRD nationallicence Epidemiology nationallicence Walker Alex Division of Epidemiology and Public Health, School of Community Health Sciences, Clinical Sciences Building, Nottingham City Hospital, University of Nottingham, NG5 1PB, Nottingham, UK aut West Joe Division of Epidemiology and Public Health, School of Community Health Sciences, Clinical Sciences Building, Nottingham City Hospital, University of Nottingham, NG5 1PB, Nottingham, UK aut Grainge Matthew Division of Epidemiology and Public Health, School of Community Health Sciences, Clinical Sciences Building, Nottingham City Hospital, University of Nottingham, NG5 1PB, Nottingham, UK aut Card Tim Division of Epidemiology and Public Health, School of Community Health Sciences, Clinical Sciences Building, Nottingham City Hospital, University of Nottingham, NG5 1PB, Nottingham, UK aut Cancer Causes & Control Springer Netherlands 22/12(2011-12-01), 1743-1747 0957-5243 22:12<1743 2011 22 10552 https://doi.org/10.1007/s10552-011-9837-1 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10552-011-9837-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Walker Alex Division of Epidemiology and Public Health, School of Community Health Sciences, Clinical Sciences Building, Nottingham City Hospital, University of Nottingham, NG5 1PB, Nottingham, UK aut NATIONALLICENCE 700 1- West Joe Division of Epidemiology and Public Health, School of Community Health Sciences, Clinical Sciences Building, Nottingham City Hospital, University of Nottingham, NG5 1PB, Nottingham, UK aut NATIONALLICENCE 700 1- Grainge Matthew Division of Epidemiology and Public Health, School of Community Health Sciences, Clinical Sciences Building, Nottingham City Hospital, University of Nottingham, NG5 1PB, Nottingham, UK aut NATIONALLICENCE 700 1- Card Tim Division of Epidemiology and Public Health, School of Community Health Sciences, Clinical Sciences Building, Nottingham City Hospital, University of Nottingham, NG5 1PB, Nottingham, UK aut NATIONALLICENCE 773 0- Cancer Causes & Control Springer Netherlands 22/12(2011-12-01), 1743-1747 0957-5243 22:12<1743 2011 22 10552 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer