caa a22 4500 445315180 CHVBK 20180317142644.0 cr unu---uuuuu 170323e20111201xx s 000 0 eng 10.1007/s10552-011-9840-6 doi (NATIONALLICENCE)springer-10.1007/s10552-011-9840-6 Long-term use of continuous-combined estrogen-progestin hormone therapy and risk of endometrial cancer [Elektronische Daten] [Amanda Phipps, Jennifer Doherty, Lynda Voigt, Deirdre Hill, Shirley Beresford, Mary Rossing, Chu Chen, Noel Weiss] The daily administered dose of progestin in continuous-combined estrogen-progestin therapy is provided to counteract the proliferative effect of estrogen on the postmenopausal endometrium. However, there remains some uncertainty as to whether use of such a combined regimen, over the long term, is associated with an altered risk of endometrial cancer. We pooled data from four population-based case-control studies of endometrial cancer in western Washington State. Cases, ages 45-74, were diagnosed between 1985 and 2005. Using logistic regression with the adjustment for confounding factors, women who had exclusively used continuous-combined estrogen-progestin therapy (90 endometrial cancer cases, 227 controls) were compared with women who had never used any type of hormone therapy (774 cases, 1,116 controls). Associations with duration and recency of use were evaluated overall and within strata defined by body mass index. Long-term use of continuous-combined estrogen-progestin therapy (≥10years) was associated with a reduced risk of endometrial cancer (OR=0.37, 95% CI: 0.21-0.66). This association was most pronounced in women with a body mass index ≥30kg/m2 (OR=0.19, 95% CI: 0.05-0.68). Associations did not differ according to recency of use. These results suggest that long duration of use of continuous-combined estrogen-progestin therapy is associated with a reduced risk of endometrial cancer. Springer Science+Business Media B.V., 2011 Endometrial cancer nationallicence Hormone therapy nationallicence Estrogen nationallicence Progestin nationallicence Body mass index nationallicence Phipps Amanda Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave. N., M4-B402, 98109, Seattle, WA, USA aut Doherty Jennifer Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave. N., M4-B402, 98109, Seattle, WA, USA aut Voigt Lynda Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave. N., M4-B402, 98109, Seattle, WA, USA aut Hill Deirdre Department of Internal Medicine, School of Medicine, University of New Mexico, Albuquerque, NM, USA aut Beresford Shirley Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave. N., M4-B402, 98109, Seattle, WA, USA aut Rossing Mary Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave. N., M4-B402, 98109, Seattle, WA, USA aut Chen Chu Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave. N., M4-B402, 98109, Seattle, WA, USA aut Weiss Noel Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave. N., M4-B402, 98109, Seattle, WA, USA aut Cancer Causes & Control Springer Netherlands 22/12(2011-12-01), 1639-1646 0957-5243 22:12<1639 2011 22 10552 https://doi.org/10.1007/s10552-011-9840-6 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10552-011-9840-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Phipps Amanda Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave. N., M4-B402, 98109, Seattle, WA, USA aut NATIONALLICENCE 700 1- Doherty Jennifer Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave. N., M4-B402, 98109, Seattle, WA, USA aut NATIONALLICENCE 700 1- Voigt Lynda Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave. N., M4-B402, 98109, Seattle, WA, USA aut NATIONALLICENCE 700 1- Hill Deirdre Department of Internal Medicine, School of Medicine, University of New Mexico, Albuquerque, NM, USA aut NATIONALLICENCE 700 1- Beresford Shirley Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave. N., M4-B402, 98109, Seattle, WA, USA aut NATIONALLICENCE 700 1- Rossing Mary Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave. N., M4-B402, 98109, Seattle, WA, USA aut NATIONALLICENCE 700 1- Chen Chu Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave. N., M4-B402, 98109, Seattle, WA, USA aut NATIONALLICENCE 700 1- Weiss Noel Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave. N., M4-B402, 98109, Seattle, WA, USA aut NATIONALLICENCE 773 0- Cancer Causes & Control Springer Netherlands 22/12(2011-12-01), 1639-1646 0957-5243 22:12<1639 2011 22 10552 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer