caa a22 4500 445315199 CHVBK 20180317142644.0 cr unu---uuuuu 170323e20111201xx s 000 0 eng 10.1007/s10552-011-9849-x doi (NATIONALLICENCE)springer-10.1007/s10552-011-9849-x Sunlight exposure, vitamin D, and risk of non-Hodgkin lymphoma in the Nurses' Health Study [Elektronische Daten] [Kimberly Bertrand, Ellen Chang, Gregory Abel, Shumin Zhang, Donna Spiegelman, Abrar Qureshi, Francine Laden] Purpose: Case-control studies suggest increased sun exposure reduces non-Hodgkin lymphoma (NHL) risk. Evidence from prospective cohort studies, however, is limited and inconsistent. We evaluated the association between ambient ultraviolet radiation (UV) exposure and NHL in a nationwide cohort of women, the Nurses' Health Study (NHS). Methods: Between 1976 and 2006, we identified 1064 incident NHL cases among 115,482 women in the prospective NHS. Exposures assessed included average annual UV-B flux based on residence at various times during life, vitamin D intake, and predicted plasma 25-hydroxyvitamin D levels. We estimated incidence rate ratios (RRs) and 95% confidence intervals (CIs) for risk of all NHL and histologic subtypes using Cox proportional hazards models. Results: NHL risk was increased for women residing in areas of high ambient UV radiation (UV-B flux >113 R-B count×10−4) compared to those with lower exposure (<113), with positive linear trends at all time points. The multivariable-adjusted RR for high UV area at age 15 was 1.21 (95% CI: 1.00, 1.47; p-trend<0.01). There was no evidence of statistical heterogeneity by subtype, although power was limited for subtype analyses. We observed no association between vitamin D measures and risk of NHL overall or by subtype. Conclusions: Our findings do not support the hypothesis of a protective effect of UV radiation exposure on NHL risk. We found no association between vitamin D and NHL risk. Springer Science+Business Media B.V., 2011 Non-Hodgkin lymphoma nationallicence Sunlight nationallicence Ultraviolet radiation nationallicence Vitamin D nationallicence Epidemiology nationallicence Bertrand Kimberly Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, 02115, Boston, MA, USA aut Chang Ellen Cancer Prevention Institute of California, Fremont, CA, USA aut Abel Gregory Center for Outcomes and Policy Research, Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA aut Zhang Shumin Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA aut Spiegelman Donna Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, 02115, Boston, MA, USA aut Qureshi Abrar Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA aut Laden Francine Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, 02115, Boston, MA, USA aut Cancer Causes & Control Springer Netherlands 22/12(2011-12-01), 1731-1741 0957-5243 22:12<1731 2011 22 10552 https://doi.org/10.1007/s10552-011-9849-x text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10552-011-9849-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Bertrand Kimberly Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, 02115, Boston, MA, USA aut NATIONALLICENCE 700 1- Chang Ellen Cancer Prevention Institute of California, Fremont, CA, USA aut NATIONALLICENCE 700 1- Abel Gregory Center for Outcomes and Policy Research, Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA aut NATIONALLICENCE 700 1- Zhang Shumin Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA aut NATIONALLICENCE 700 1- Spiegelman Donna Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, 02115, Boston, MA, USA aut NATIONALLICENCE 700 1- Qureshi Abrar Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA aut NATIONALLICENCE 700 1- Laden Francine Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, 02115, Boston, MA, USA aut NATIONALLICENCE 773 0- Cancer Causes & Control Springer Netherlands 22/12(2011-12-01), 1731-1741 0957-5243 22:12<1731 2011 22 10552 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer