caa a22 4500 445315229 CHVBK 20180317142644.0 cr unu---uuuuu 170323e20111201xx s 000 0 eng 10.1007/s10552-011-9839-z doi (NATIONALLICENCE)springer-10.1007/s10552-011-9839-z A prospective study of intakes of zinc and heme iron and colorectal cancer risk in men and women [Elektronische Daten] [Xuehong Zhang, Edward Giovannucci, Stephanie Smith-Warner, Kana Wu, Charles Fuchs, Michael Pollak, Walter Willett, Jing Ma] Although laboratory studies linked zinc and heme iron to colorectal cancer, epidemiologic evidence is limited. We prospectively examined these associations in the Nurses' Health Study and Health Professionals Follow-up Study. We used Cox proportional hazards regression analyses to calculate cohort-specific relative risks (RRs) and pooled results using a fixed-effects model. We documented 2,114 incident colorectal cancer cases during up to 22years of follow-up. Compared highest to lowest quintile of dietary zinc intake, the pooled multivariable RRs (95% CIs) were 0.86 (0.73, 1.02) for colorectal cancer, 0.92 (0.76, 1.11) for colon cancer, and 0.68 (0.47, 0.99) for rectal cancer. The significant inverse association between dietary zinc intake and risk of rectal cancer was mainly driven by data in women, although the difference in the sex-specific results was not statistically significant. For the same comparison, the pooled multivariable RRs (95% CIs) for heme iron were 1.10 (0.93, 1.30) for colorectal cancer, 1.06 (0.88, 1.29) for colon cancer, and 1.20 (0.83, 1.75) for rectal cancer. These associations were not significantly modified by alcohol consumption, body mass index, physical activity, menopausal status, or postmenopausal hormone use. Total zinc intake, total iron intake, dietary iron intake, and zinc or iron supplement uses were largely not associated with colorectal cancer risk. Our study does not support strong roles of zinc and heme iron intake in colorectal cancer risk; however, a suggestive inverse association of dietary zinc intake with rectal cancer risk in women requires further study. Springer Science+Business Media B.V., 2011 Colorectal cancer nationallicence Zinc nationallicence Iron nationallicence Heme iron nationallicence Cohort study nationallicence Zhang Xuehong Channing Laboratory at Landmark Center (West Wing), Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, 401 Park Drive, 02115, Boston, MA, USA aut Giovannucci Edward Channing Laboratory at Landmark Center (West Wing), Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, 401 Park Drive, 02115, Boston, MA, USA aut Smith-Warner Stephanie Department of Nutrition, Harvard School of Public Health, Boston, MA, USA aut Wu Kana Department of Nutrition, Harvard School of Public Health, Boston, MA, USA aut Fuchs Charles Channing Laboratory at Landmark Center (West Wing), Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, 401 Park Drive, 02115, Boston, MA, USA aut Pollak Michael Department of Oncology, McGill University and Lady Davis Research Institute, 3999 Rue Côte Sainte Catherine, H3T 1E2, Montreal, QC, Canada aut Willett Walter Channing Laboratory at Landmark Center (West Wing), Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, 401 Park Drive, 02115, Boston, MA, USA aut Ma Jing Channing Laboratory at Landmark Center (West Wing), Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, 401 Park Drive, 02115, Boston, MA, USA aut Cancer Causes & Control Springer Netherlands 22/12(2011-12-01), 1627-1637 0957-5243 22:12<1627 2011 22 10552 https://doi.org/10.1007/s10552-011-9839-z text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10552-011-9839-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Zhang Xuehong Channing Laboratory at Landmark Center (West Wing), Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, 401 Park Drive, 02115, Boston, MA, USA aut NATIONALLICENCE 700 1- Giovannucci Edward Channing Laboratory at Landmark Center (West Wing), Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, 401 Park Drive, 02115, Boston, MA, USA aut NATIONALLICENCE 700 1- Smith-Warner Stephanie Department of Nutrition, Harvard School of Public Health, Boston, MA, USA aut NATIONALLICENCE 700 1- Wu Kana Department of Nutrition, Harvard School of Public Health, Boston, MA, USA aut NATIONALLICENCE 700 1- Fuchs Charles Channing Laboratory at Landmark Center (West Wing), Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, 401 Park Drive, 02115, Boston, MA, USA aut NATIONALLICENCE 700 1- Pollak Michael Department of Oncology, McGill University and Lady Davis Research Institute, 3999 Rue Côte Sainte Catherine, H3T 1E2, Montreal, QC, Canada aut NATIONALLICENCE 700 1- Willett Walter Channing Laboratory at Landmark Center (West Wing), Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, 401 Park Drive, 02115, Boston, MA, USA aut NATIONALLICENCE 700 1- Ma Jing Channing Laboratory at Landmark Center (West Wing), Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, 401 Park Drive, 02115, Boston, MA, USA aut NATIONALLICENCE 773 0- Cancer Causes & Control Springer Netherlands 22/12(2011-12-01), 1627-1637 0957-5243 22:12<1627 2011 22 10552 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer