caa a22 4500 445315253 CHVBK 20180317142644.0 cr unu---uuuuu 170323e20110301xx s 000 0 eng 10.1007/s10552-010-9721-4 doi (NATIONALLICENCE)springer-10.1007/s10552-010-9721-4 Reduction of hepatocellular carcinoma in childhood after introduction of selective vaccination against hepatitis B virus for infants born to HBV carrier mothers [Elektronische Daten] [Hitoshi Tajiri, Hideo Tanaka, Stephen Brooks, Tomoko Takano] Objective: A nation-wide prevention program utilizing passive-active immunoprophylaxis for high-risk babies against maternal HBV transmission was introduced in Japan in January of 1986. The prevention program was expected to eradicate HBV-related hepatocellular carcinoma (HCC). The aim of this study was to evaluate the effect of this selective prevention program against maternal HBV transmission on the occurrence of HBV-related HCC. Methods: We reviewed the annual reports from a nation-wide survey of childhood solid tumors that was reported in the Journal of the Japanese Society of Pediatric Surgeons during the 28years period from 1981 to 2008. The number of HCC cases were grouped for every 5-year period with an additional period of the past 3years and compared with those of hepatoblastoma. Results: The reported number of children with hepatoblastoma in each period was constant during the 28years study period. In contrast, both the number of patients with HBV-related HCC and the ratio of HBV-related HCC to hepatoblastoma gradually decreased over the study period, with a significant drop in the last two periods ranging from 2001 to 2008 (p<0.001). Conclusion: The prevention program against maternal HBV infection of infants born to HBV carrier mothers may have decreased the occurrence of HBV-related HCC in childhood. Springer Science+Business Media B.V., 2010 Hepatocellular carcinoma nationallicence Hepatitis B virus nationallicence Selective vaccination nationallicence Maternal transmission nationallicence Tajiri Hitoshi Department of Paediatrics, Osaka General Medical Center, 3-1-56 Bandaihigashi, 558-8558, Sumiyoshi-ku, Osaka, Japan aut Tanaka Hideo Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan aut Brooks Stephen Department of Microbiology/Immunology, State University of New York at Buffalo, Buffalo, NY, USA aut Takano Tomoko Department of Paediatrics, Osaka General Medical Center, 3-1-56 Bandaihigashi, 558-8558, Sumiyoshi-ku, Osaka, Japan aut Cancer Causes & Control Springer Netherlands 22/3(2011-03-01), 523-527 0957-5243 22:3<523 2011 22 10552 https://doi.org/10.1007/s10552-010-9721-4 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10552-010-9721-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Tajiri Hitoshi Department of Paediatrics, Osaka General Medical Center, 3-1-56 Bandaihigashi, 558-8558, Sumiyoshi-ku, Osaka, Japan aut NATIONALLICENCE 700 1- Tanaka Hideo Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan aut NATIONALLICENCE 700 1- Brooks Stephen Department of Microbiology/Immunology, State University of New York at Buffalo, Buffalo, NY, USA aut NATIONALLICENCE 700 1- Takano Tomoko Department of Paediatrics, Osaka General Medical Center, 3-1-56 Bandaihigashi, 558-8558, Sumiyoshi-ku, Osaka, Japan aut NATIONALLICENCE 773 0- Cancer Causes & Control Springer Netherlands 22/3(2011-03-01), 523-527 0957-5243 22:3<523 2011 22 10552 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer