caa a22 4500 445315261 CHVBK 20180317142644.0 cr unu---uuuuu 170323e20110301xx s 000 0 eng 10.1007/s10552-010-9711-6 doi (NATIONALLICENCE)springer-10.1007/s10552-010-9711-6 Bladder cancer mortality trends and patterns in Córdoba, Argentina (1986-2006) [Elektronische Daten] [Sonia Pou, Alberto Osella, Maria Diaz] Background: Bladder cancer is common worldwide and the fourth most commonly diagnosed malignancy in men in Argentina. Objective: To describe bladder cancer mortality trends in Córdoba (1986-2006), considering the effect of age, period, and cohort, and to estimate the effect of arsenic exposure on bladder cancer, and its interaction with sex, while controlling by smoking habits and space and time variation of the rates. Methods: A joinpoint regression was performed to compute the estimated annual percentage changes (EAPC) of the age-standardized mortality rates (ASMR) in an adult population from Córdoba, Argentina. A Poisson model was fitted to estimate the effect of age, period, and cohort. The influence of gender, tobacco smoking (using lung cancer ASMR as surrogate), and arsenic in drinking water was examined using a hierarchical model. Results: A favorable trend (1986-2006) in bladder cancer ASMR in both sexes was found: EAPC of −2.54 in men and −1.69 in women. There was a decreasing trend in relative risk (RR) for cohorts born in 1931 or after. The multilevel model showed an increasing risk for each increase in lung cancer ASMR unit (RR=1.001) and a biological interaction between sex and arsenic exposure. RR was higher among men exposed to increasing As-exposure categories (RR male low exposure 3.14, RR male intermediate exposure 4.03, RR male high exposure 4.71 versus female low exposure). A non-random space-time distribution of the rates was observed. Conclusions: There has been a decreasing trend in ASMR for bladder cancer in Córdoba. This study confirms that bladder cancer is associated with age, gender, smoking habit, and exposure to arsenic. Moreover, an effect measure modification between exposure to arsenic and sex was found. Springer Science+Business Media B.V., 2010 Bladder cancer nationallicence Mortality nationallicence Arsenic exposure nationallicence Tobacco smoking nationallicence Cohort effect nationallicence Córdoba nationallicence Argentina nationallicence Pou Sonia Celular Biology Institute, Faculty of Medical Sciences, University of Córdoba, Córdoba, Argentina aut Osella Alberto Celular Biology Institute, Faculty of Medical Sciences, University of Córdoba, Córdoba, Argentina aut Diaz Maria Celular Biology Institute, Faculty of Medical Sciences, University of Córdoba, Córdoba, Argentina aut Cancer Causes & Control Springer Netherlands 22/3(2011-03-01), 407-415 0957-5243 22:3<407 2011 22 10552 https://doi.org/10.1007/s10552-010-9711-6 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10552-010-9711-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Pou Sonia Celular Biology Institute, Faculty of Medical Sciences, University of Córdoba, Córdoba, Argentina aut NATIONALLICENCE 700 1- Osella Alberto Celular Biology Institute, Faculty of Medical Sciences, University of Córdoba, Córdoba, Argentina aut NATIONALLICENCE 700 1- Diaz Maria Celular Biology Institute, Faculty of Medical Sciences, University of Córdoba, Córdoba, Argentina aut NATIONALLICENCE 773 0- Cancer Causes & Control Springer Netherlands 22/3(2011-03-01), 407-415 0957-5243 22:3<407 2011 22 10552 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer