caa a22 4500 44531527X CHVBK 20180317142644.0 cr unu---uuuuu 170323e20110301xx s 000 0 eng 10.1007/s10552-010-9714-3 doi (NATIONALLICENCE)springer-10.1007/s10552-010-9714-3 Physical activity, additional breast cancer events, and mortality among early-stage breast cancer survivors: findings from the WHEL Study [Elektronische Daten] [Lisa Bertram, Marcia Stefanick, Nazmus Saquib, Loki Natarajan, Ruth Patterson, Wayne Bardwell, Shirley Flatt, Vicky Newman, Cheryl Rock, Cynthia Thomson, John Pierce] Objective: Research suggests that physical activity is associated with improved breast cancer survival, yet no studies have examined the association between post-diagnosis changes in physical activity and breast cancer outcomes. The aim of this study was to determine whether baseline activity and 1-year change in activity are associated with breast cancer events or mortality. Methods: A total of 2,361 post-treatment breast cancer survivors (Stage I-III) enrolled in a randomized controlled trial of dietary change completed physical activity measures at baseline and one year. Physical activity variables (total, moderate-vigorous, and adherence to guidelines) were calculated for each time point. Median follow-up was 7.1years. Outcomes were invasive breast cancer events and all-cause mortality. Results: Those who were most active at baseline had a 53% lower mortality risk compared to the least active women (HR=0.47; 95% CI: 0.26, 0.84; p=.01). Adherence to activity guidelines was associated with a 35% lower mortality risk (HR=0.65, 95% CI: 0.47, 0.91; p<.01). Neither baseline nor 1-year change in activity was associated with additional breast cancer events. Conclusions: Higher baseline (post-treatment) physical activity was associated with improved survival. However, change in activity over the following year was not associated with outcomes. These data suggest that long-term physical activity levels are important for breast cancer prognosis. The Author(s), 2010 Exercise nationallicence Recurrence nationallicence Survival nationallicence Behavior nationallicence Lifestyle nationallicence Bertram Lisa Moores UCSD Cancer Center, University of California, 3855 Health Sciences Drive, 94305-5411, San Diego, La Jolla, CA, USA aut Stefanick Marcia Stanford Prevention Research Center, Stanford University, 251 Campus Drive, 94305-5411, Stanford, CA, USA aut Saquib Nazmus Moores UCSD Cancer Center, University of California, 3855 Health Sciences Drive, 94305-5411, San Diego, La Jolla, CA, USA aut Natarajan Loki Moores UCSD Cancer Center, University of California, 3855 Health Sciences Drive, 94305-5411, San Diego, La Jolla, CA, USA aut Patterson Ruth Moores UCSD Cancer Center, University of California, 3855 Health Sciences Drive, 94305-5411, San Diego, La Jolla, CA, USA aut Bardwell Wayne Moores UCSD Cancer Center, University of California, 3855 Health Sciences Drive, 94305-5411, San Diego, La Jolla, CA, USA aut Flatt Shirley Moores UCSD Cancer Center, University of California, 3855 Health Sciences Drive, 94305-5411, San Diego, La Jolla, CA, USA aut Newman Vicky Moores UCSD Cancer Center, University of California, 3855 Health Sciences Drive, 94305-5411, San Diego, La Jolla, CA, USA aut Rock Cheryl Moores UCSD Cancer Center, University of California, 3855 Health Sciences Drive, 94305-5411, San Diego, La Jolla, CA, USA aut Thomson Cynthia Arizona Cancer Center, Department of Nutritional Sciences, University of Arizona, 1177 E. 4th Street, 85721, Tucson, AZ, USA aut Pierce John Moores UCSD Cancer Center, University of California, 3855 Health Sciences Drive, 94305-5411, San Diego, La Jolla, CA, USA aut Cancer Causes & Control Springer Netherlands 22/3(2011-03-01), 427-435 0957-5243 22:3<427 2011 22 10552 https://doi.org/10.1007/s10552-010-9714-3 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10552-010-9714-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Bertram Lisa Moores UCSD Cancer Center, University of California, 3855 Health Sciences Drive, 94305-5411, San Diego, La Jolla, CA, USA aut NATIONALLICENCE 700 1- Stefanick Marcia Stanford Prevention Research Center, Stanford University, 251 Campus Drive, 94305-5411, Stanford, CA, USA aut NATIONALLICENCE 700 1- Saquib Nazmus Moores UCSD Cancer Center, University of California, 3855 Health Sciences Drive, 94305-5411, San Diego, La Jolla, CA, USA aut NATIONALLICENCE 700 1- Natarajan Loki Moores UCSD Cancer Center, University of California, 3855 Health Sciences Drive, 94305-5411, San Diego, La Jolla, CA, USA aut NATIONALLICENCE 700 1- Patterson Ruth Moores UCSD Cancer Center, University of California, 3855 Health Sciences Drive, 94305-5411, San Diego, La Jolla, CA, USA aut NATIONALLICENCE 700 1- Bardwell Wayne Moores UCSD Cancer Center, University of California, 3855 Health Sciences Drive, 94305-5411, San Diego, La Jolla, CA, USA aut NATIONALLICENCE 700 1- Flatt Shirley Moores UCSD Cancer Center, University of California, 3855 Health Sciences Drive, 94305-5411, San Diego, La Jolla, CA, USA aut NATIONALLICENCE 700 1- Newman Vicky Moores UCSD Cancer Center, University of California, 3855 Health Sciences Drive, 94305-5411, San Diego, La Jolla, CA, USA aut NATIONALLICENCE 700 1- Rock Cheryl Moores UCSD Cancer Center, University of California, 3855 Health Sciences Drive, 94305-5411, San Diego, La Jolla, CA, USA aut NATIONALLICENCE 700 1- Thomson Cynthia Arizona Cancer Center, Department of Nutritional Sciences, University of Arizona, 1177 E. 4th Street, 85721, Tucson, AZ, USA aut NATIONALLICENCE 700 1- Pierce John Moores UCSD Cancer Center, University of California, 3855 Health Sciences Drive, 94305-5411, San Diego, La Jolla, CA, USA aut NATIONALLICENCE 773 0- Cancer Causes & Control Springer Netherlands 22/3(2011-03-01), 427-435 0957-5243 22:3<427 2011 22 10552 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer