caa a22 4500 445315288 CHVBK 20180317142644.0 cr unu---uuuuu 170323e20110301xx s 000 0 eng 10.1007/s10552-010-9716-1 doi (NATIONALLICENCE)springer-10.1007/s10552-010-9716-1 Chromosome 15q24-25.1 variants, diet, and lung cancer susceptibility in cigarette smokers [Elektronische Daten] [Lori Sakoda, Melissa Loomis, Jennifer Doherty, Marian Neuhouser, Matt Barnett, Mark Thornquist, Noel Weiss, Gary Goodman, Chu Chen] Background: Studying gene-environment interactions may provide insight about mechanisms underpinning the reported association between chromosome 15q24-25.1 variation and lung cancer susceptibility. Methods: In a nested case-control study comparing 746 lung cancer cases to 1,477 controls, all of whom were non-Hispanic white smokers in the β-Carotene and Retinol Efficacy Trial, we examined whether lung cancer risk is associated with single nucleotide polymorphisms (SNPs) tagging the AGPHD1, CHRNA5, CHRNA3, and CHRNB4 genes and whether such risk is modified by diet and other characteristics. Intake of fruits and vegetables, their botanical groups, and specific nutrients were ascertained generally at baseline by food-frequency questionnaire. Results: Several sets of SNPs in high linkage disequilibrium were found: one set associated with a 27-34% increase and two sets associated with a 13-19% decrease in risk per minor allele. Associations were most prominent for the set including the non-synonymous SNP rs16969968. The rs16969968-lung cancer association did not differ by intake level of most dietary factors examined, but was stronger for individuals diagnosed at <70years of age or having a baseline smoking history of <40 cigarette pack-years. Conclusions: Our data suggests that diet has little influence on the relation between chromosome 15q24-25.1 variation and lung cancer risk. Springer Science+Business Media B.V., 2011 Lung cancer nationallicence Genetic polymorphism nationallicence Nicotinic acetylcholine receptors nationallicence Diet nationallicence AGPHD1 : Aminoglycoside phosphotransferase domain containing 1 nationallicence CARET : β-Carotene and Retinol Efficacy Trial nationallicence CHRNA5 : Cholinergic receptor, nicotinic, alpha 5 nationallicence CHRNA3 : Cholinergic receptor, nicotinic, alpha 3 nationallicence CHRNB4 : Cholinergic receptor, nicotinic, beta 4 nationallicence CI : Confidence interval nationallicence FFQ : Food-frequency questionnaire nationallicence IREB2 : Iron-responsive element binding protein 2 nationallicence LD : Linkage disequilibrium nationallicence nAChR : Nicotinic acetylcholine receptor nationallicence PFA : Polyunsaturated fatty acid nationallicence PSMA4 : Proteasome subunit, alpha type 4 nationallicence OR : Odds ratio nationallicence SNP : Single nucleotide polymorphism nationallicence Sakoda Lori Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, P.O. Box 19024, Mailstop M4-C308, 98109-1024, Seattle, WA, USA aut Loomis Melissa Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, P.O. Box 19024, Mailstop M5-C800, 98109-1024, Seattle, WA, USA aut Doherty Jennifer Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, P.O. Box 19024, Mailstop M4-C308, 98109-1024, Seattle, WA, USA aut Neuhouser Marian Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, P.O. Box 19024, Mailstop M4-B402, 98109-1024, Seattle, WA, USA aut Barnett Matt Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, P.O. Box 19024, Mailstop M3-A306, 98109-1024, Seattle, WA, USA aut Thornquist Mark Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, P.O. Box 19024, Mailstop M3-A306, 98109-1024, Seattle, WA, USA aut Weiss Noel Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, P.O. Box 19024, Mailstop M4-C308, 98109-1024, Seattle, WA, USA aut Goodman Gary Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, P.O. Box 19024, Mailstop M3-A306, 98109-1024, Seattle, WA, USA aut Chen Chu Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, P.O. Box 19024, Mailstop M5-C800, 98109-1024, Seattle, WA, USA aut Cancer Causes & Control Springer Netherlands 22/3(2011-03-01), 449-461 0957-5243 22:3<449 2011 22 10552 https://doi.org/10.1007/s10552-010-9716-1 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10552-010-9716-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Sakoda Lori Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, P.O. Box 19024, Mailstop M4-C308, 98109-1024, Seattle, WA, USA aut NATIONALLICENCE 700 1- Loomis Melissa Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, P.O. Box 19024, Mailstop M5-C800, 98109-1024, Seattle, WA, USA aut NATIONALLICENCE 700 1- Doherty Jennifer Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, P.O. Box 19024, Mailstop M4-C308, 98109-1024, Seattle, WA, USA aut NATIONALLICENCE 700 1- Neuhouser Marian Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, P.O. Box 19024, Mailstop M4-B402, 98109-1024, Seattle, WA, USA aut NATIONALLICENCE 700 1- Barnett Matt Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, P.O. Box 19024, Mailstop M3-A306, 98109-1024, Seattle, WA, USA aut NATIONALLICENCE 700 1- Thornquist Mark Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, P.O. Box 19024, Mailstop M3-A306, 98109-1024, Seattle, WA, USA aut NATIONALLICENCE 700 1- Weiss Noel Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, P.O. Box 19024, Mailstop M4-C308, 98109-1024, Seattle, WA, USA aut NATIONALLICENCE 700 1- Goodman Gary Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, P.O. Box 19024, Mailstop M3-A306, 98109-1024, Seattle, WA, USA aut NATIONALLICENCE 700 1- Chen Chu Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, P.O. Box 19024, Mailstop M5-C800, 98109-1024, Seattle, WA, USA aut NATIONALLICENCE 773 0- Cancer Causes & Control Springer Netherlands 22/3(2011-03-01), 449-461 0957-5243 22:3<449 2011 22 10552 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer