caa a22 4500 44531530X CHVBK 20180317142644.0 cr unu---uuuuu 170323e20110301xx s 000 0 eng 10.1007/s10552-010-9718-z doi (NATIONALLICENCE)springer-10.1007/s10552-010-9718-z Dietary intake of micronutrients and the risk of developing bladder cancer: results from the Belgian case-control study on bladder cancer risk [Elektronische Daten] [Maree Brinkman, Frank Buntinx, Eliane Kellen, Pieter Dagnelie, Martien Van Dongen, Erik Muls, Maurice Zeegers] Objective: We aimed to investigate the effect of dietary intake of micronutrients that are metabolized and excreted via the urinary tract on bladder cancer risk. Methods: A semi-quantitative 322 item food frequency questionnaire (FFQ) was used to collect dietary data from 200 bladder cancer cases and 386 control subjects participating in the Belgian case-control study on bladder cancer risk. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using unconditional logistic regression adjusting for age, sex, smoking characteristics, occupational exposures, and energy intake. Results: We observed a positive association between calcium intake and bladder cancer (OR: 1.77; 95% CI: 1.00-3.15; p-trend=0.049) and increased odds, although not statistically significant, for highest tertile of phosphorus intake (OR: 1.82; 95% CI: 0.95-3.49; p-trend=0.06). We identified possible modification of the effects of both calcium and phosphorus by level of magnesium intake. Increased odds of bladder cancer were also observed for participants with highest intake of phosphorus and lowest intake of vitamin D (OR: 4.25; 95% CI: 1.44-12.55) and among older participants with the highest intakes of calcium (OR: 1.90; 95% CI: 1.08-3.36) and phosphorus (OR: 2.02; 95% CI: 1.05-3.92). Conclusion: The positive associations we observed between bladder cancer and intake of calcium and phosphorus require confirmation by other studies. The balances between inter-related micronutrients also warrant further examination. The Author(s), 2010 Bladder cancer nationallicence Micronutrients nationallicence Calcium nationallicence Vitamin D nationallicence Brinkman Maree Department of General Practice, Katholieke Universiteit Leuven, Comprehensive Cancer Institute Limburg (LIKAS), Leuven, Belgium aut Buntinx Frank Department of General Practice, Katholieke Universiteit Leuven, Comprehensive Cancer Institute Limburg (LIKAS), Leuven, Belgium aut Kellen Eliane Leuven Centre for Cancer Prevention, University Hospitals Leuven, Leuven, Belgium aut Dagnelie Pieter Department of Epidemiology, Maastricht University, Maastricht, The Netherlands aut Van Dongen Martien Department of Epidemiology, Maastricht University, Maastricht, The Netherlands aut Muls Erik Department of Endocrinology, Metabolism and Nutrition, University Hospital, Gasthuisberg, Leuven, Belgium aut Zeegers Maurice Unit of Urologic and Genetic Epidemiology, Department of Public Health, Epidemiology and Biostatistics, University of Birmingham, Birmingham, UK aut Cancer Causes & Control Springer Netherlands 22/3(2011-03-01), 469-478 0957-5243 22:3<469 2011 22 10552 https://doi.org/10.1007/s10552-010-9718-z text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10552-010-9718-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Brinkman Maree Department of General Practice, Katholieke Universiteit Leuven, Comprehensive Cancer Institute Limburg (LIKAS), Leuven, Belgium aut NATIONALLICENCE 700 1- Buntinx Frank Department of General Practice, Katholieke Universiteit Leuven, Comprehensive Cancer Institute Limburg (LIKAS), Leuven, Belgium aut NATIONALLICENCE 700 1- Kellen Eliane Leuven Centre for Cancer Prevention, University Hospitals Leuven, Leuven, Belgium aut NATIONALLICENCE 700 1- Dagnelie Pieter Department of Epidemiology, Maastricht University, Maastricht, The Netherlands aut NATIONALLICENCE 700 1- Van Dongen Martien Department of Epidemiology, Maastricht University, Maastricht, The Netherlands aut NATIONALLICENCE 700 1- Muls Erik Department of Endocrinology, Metabolism and Nutrition, University Hospital, Gasthuisberg, Leuven, Belgium aut NATIONALLICENCE 700 1- Zeegers Maurice Unit of Urologic and Genetic Epidemiology, Department of Public Health, Epidemiology and Biostatistics, University of Birmingham, Birmingham, UK aut NATIONALLICENCE 773 0- Cancer Causes & Control Springer Netherlands 22/3(2011-03-01), 469-478 0957-5243 22:3<469 2011 22 10552 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer