caa a22 4500 445315326 CHVBK 20180317142644.0 cr unu---uuuuu 170323e20110301xx s 000 0 eng 10.1007/s10552-010-9719-y doi (NATIONALLICENCE)springer-10.1007/s10552-010-9719-y Does hormone therapy counter the beneficial effects of physical activity on breast cancer risk in postmenopausal women? [Elektronische Daten] [Christina Dieli-Conwright, Jane Sullivan-Halley, Alpa Patel, Michael Press, Kathleen Malone, Giske Ursin, Ronald Burkman, Brian Strom, Michael Simon, Linda Weiss, Polly Marchbanks, Suzanne Folger, Robert Spirtas, Dennis Deapen, Leslie Bernstein] Studies consistently demonstrate that physical activity is inversely associated with postmenopausal breast cancer. Whether this association is stronger among non-hormone users or former users of menopausal hormone therapy (HT) is of interest given the marked decline in HT use since 2002. The Women's Contraceptive and Reproductive Experiences Study, a population-based case-control study of invasive breast cancer, recruited white women and black women ages 35-64years and collected histories of lifetime recreational physical activity and HT use including estrogen-alone therapy (ET) and estrogen plus progestin therapy (EPT). Among postmenopausal women (1,908 cases, 2,013 control participants), breast cancer risk declined with increasing levels of lifetime physical activity among never HT users; among short-term HT users (fewer than 5years); and among current ET users; P trend values ranged from 0.004 to 0.016. In contrast, physical activity had no significant association with risk among long-term and past HT users and among current EPT users. No statistical evidence of heterogeneity was demonstrated for duration or currency of HT use. Breast cancer risk decreases with increasing lifetime physical activity levels among postmenopausal women who have not used HT, have used HT for less than 5years, or are current ET users, yet this study was unable to demonstrate statistically that HT use modifies the relationship between physical activity and breast cancer. With profound changes in HT use occurring since 2002, it will be important in future studies to learn whether or not any association between physical activity and breast cancer among former HT users is a function of time since last HT use. Springer Science+Business Media B.V., 2011 Hormone therapy nationallicence Physical activity nationallicence Breast cancer nationallicence Dieli-Conwright Christina Division of Cancer Etiology, Department of Population Sciences, City of Hope National Medical Center, 1500 East Duarte Road, 91010, Duarte, CA, USA aut Sullivan-Halley Jane Division of Cancer Etiology, Department of Population Sciences, City of Hope National Medical Center, 1500 East Duarte Road, 91010, Duarte, CA, USA aut Patel Alpa Department of Epidemiology, American Cancer Society, Atlanta, GA, USA aut Press Michael Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA aut Malone Kathleen Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA, USA aut Ursin Giske Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA aut Burkman Ronald Department of Obstetrics and Gynecology, Baystate Medical Center, Springfield, MA, USA aut Strom Brian Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, PA, USA aut Simon Michael Department of Medicine and Oncology, Karmanos Cancer Institute, Detroit, MI, USA aut Weiss Linda Cancer Centers Program, National Cancer Institute, Bethesda, MD, USA aut Marchbanks Polly Centers for Disease Control, Atlanta, GA, USA aut Folger Suzanne Centers for Disease Control, Atlanta, GA, USA aut Spirtas Robert Contraceptive and Reproductive Health Branch, Center for Population Research, National Institute of Child Health and Development, Bethesda, MD, USA aut Deapen Dennis Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA aut Bernstein Leslie Division of Cancer Etiology, Department of Population Sciences, City of Hope National Medical Center, 1500 East Duarte Road, 91010, Duarte, CA, USA aut Cancer Causes & Control Springer Netherlands 22/3(2011-03-01), 515-522 0957-5243 22:3<515 2011 22 10552 https://doi.org/10.1007/s10552-010-9719-y text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10552-010-9719-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Dieli-Conwright Christina Division of Cancer Etiology, Department of Population Sciences, City of Hope National Medical Center, 1500 East Duarte Road, 91010, Duarte, CA, USA aut NATIONALLICENCE 700 1- Sullivan-Halley Jane Division of Cancer Etiology, Department of Population Sciences, City of Hope National Medical Center, 1500 East Duarte Road, 91010, Duarte, CA, USA aut NATIONALLICENCE 700 1- Patel Alpa Department of Epidemiology, American Cancer Society, Atlanta, GA, USA aut NATIONALLICENCE 700 1- Press Michael Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA aut NATIONALLICENCE 700 1- Malone Kathleen Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA, USA aut NATIONALLICENCE 700 1- Ursin Giske Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA aut NATIONALLICENCE 700 1- Burkman Ronald Department of Obstetrics and Gynecology, Baystate Medical Center, Springfield, MA, USA aut NATIONALLICENCE 700 1- Strom Brian Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, PA, USA aut NATIONALLICENCE 700 1- Simon Michael Department of Medicine and Oncology, Karmanos Cancer Institute, Detroit, MI, USA aut NATIONALLICENCE 700 1- Weiss Linda Cancer Centers Program, National Cancer Institute, Bethesda, MD, USA aut NATIONALLICENCE 700 1- Marchbanks Polly Centers for Disease Control, Atlanta, GA, USA aut NATIONALLICENCE 700 1- Folger Suzanne Centers for Disease Control, Atlanta, GA, USA aut NATIONALLICENCE 700 1- Spirtas Robert Contraceptive and Reproductive Health Branch, Center for Population Research, National Institute of Child Health and Development, Bethesda, MD, USA aut NATIONALLICENCE 700 1- Deapen Dennis Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA aut NATIONALLICENCE 700 1- Bernstein Leslie Division of Cancer Etiology, Department of Population Sciences, City of Hope National Medical Center, 1500 East Duarte Road, 91010, Duarte, CA, USA aut NATIONALLICENCE 773 0- Cancer Causes & Control Springer Netherlands 22/3(2011-03-01), 515-522 0957-5243 22:3<515 2011 22 10552 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer