caa a22 4500 445315350 CHVBK 20180317142644.0 cr unu---uuuuu 170323e20110301xx s 000 0 eng 10.1007/s10552-010-9725-0 doi (NATIONALLICENCE)springer-10.1007/s10552-010-9725-0 Coffee consumption and reduced risk of hepatocellular carcinoma: findings from the Singapore Chinese Health Study [Elektronische Daten] [Shane Johnson, Woon-Puay Koh, Renwei Wang, Sugantha Govindarajan, Mimi Yu, Jian-Min Yuan] Background: Coffee consumption has been associated with reduced markers of hepatic cell damage, reduced risk of chronic liver disease, and cirrhosis across a variety of populations. Data on the association between coffee consumption and risk of hepatocellular carcinoma (HCC), especially in high-risk populations, are sparse. Methods: This study examines the relationship between coffee and caffeine consumption, and the risk of developing HCC within the Singapore Chinese Health Study, a prospective cohort of 63,257 middle-aged and older Chinese men and women, a relatively high-risk population for HCC. Baseline data on coffee consumption and other dietary and lifestyle factors were collected through in-person interviews at enrollment between 1993 and 1998. Results: As of 31 December 2006, 362 cohort participants had developed HCC. High levels of coffee or caffeine consumption were associated with reduced risk of HCC (p for trend<0.05). Compared with non-drinkers of coffee, individuals who consumed three or more cups of coffee per day experienced a statistically significant 44% reduction in risk of HCC (hazard ratio 0.56, 95% confidence interval, 0.31-1.00, p=.049) after adjustment for potential confounders and tea consumption. Conclusion: These data suggest that coffee consumption may reduce the risk of developing HCC in Chinese in Singapore. Springer Science+Business Media B.V., 2011 Coffee nationallicence Caffeine nationallicence HCC nationallicence Hepatocellular nationallicence Liver cancer nationallicence GGT nationallicence Johnson Shane The Masonic Cancer Center, MMC 806, University of Minnesota, 425 East River Road, 55455, Minneapolis, MN, USA aut Koh Woon-Puay Department of Epidemiology and Public Health, Yong Loo Lin School of Medicine, National University of Singapore, Kent Ridge, Singapore aut Wang Renwei The Masonic Cancer Center, MMC 806, University of Minnesota, 425 East River Road, 55455, Minneapolis, MN, USA aut Govindarajan Sugantha Department of Clinical Pathology, Rancho Los Amigos National Rehabilitation Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA aut Yu Mimi The Masonic Cancer Center, MMC 806, University of Minnesota, 425 East River Road, 55455, Minneapolis, MN, USA aut Yuan Jian-Min The Masonic Cancer Center, MMC 806, University of Minnesota, 425 East River Road, 55455, Minneapolis, MN, USA aut Cancer Causes & Control Springer Netherlands 22/3(2011-03-01), 503-510 0957-5243 22:3<503 2011 22 10552 https://doi.org/10.1007/s10552-010-9725-0 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10552-010-9725-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Johnson Shane The Masonic Cancer Center, MMC 806, University of Minnesota, 425 East River Road, 55455, Minneapolis, MN, USA aut NATIONALLICENCE 700 1- Koh Woon-Puay Department of Epidemiology and Public Health, Yong Loo Lin School of Medicine, National University of Singapore, Kent Ridge, Singapore aut NATIONALLICENCE 700 1- Wang Renwei The Masonic Cancer Center, MMC 806, University of Minnesota, 425 East River Road, 55455, Minneapolis, MN, USA aut NATIONALLICENCE 700 1- Govindarajan Sugantha Department of Clinical Pathology, Rancho Los Amigos National Rehabilitation Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA aut NATIONALLICENCE 700 1- Yu Mimi The Masonic Cancer Center, MMC 806, University of Minnesota, 425 East River Road, 55455, Minneapolis, MN, USA aut NATIONALLICENCE 700 1- Yuan Jian-Min The Masonic Cancer Center, MMC 806, University of Minnesota, 425 East River Road, 55455, Minneapolis, MN, USA aut NATIONALLICENCE 773 0- Cancer Causes & Control Springer Netherlands 22/3(2011-03-01), 503-510 0957-5243 22:3<503 2011 22 10552 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer