caa a22 4500 445315393 CHVBK 20180317142645.0 cr unu---uuuuu 170323e20110301xx s 000 0 eng 10.1007/s10552-010-9709-0 doi (NATIONALLICENCE)springer-10.1007/s10552-010-9709-0 Reproductive history and risk of three breast cancer subtypes defined by three biomarkers [Elektronische Daten] [Amanda Phipps, Diana Buist, Kathleen Malone, William Barlow, Peggy Porter, Karla Kerlikowske, Christopher Li] Breast cancer subtypes defined by estrogen receptor (ER), progesterone receptor (PR), and HER2 expression are biologically distinct and thus, may have distinct etiologies. In particular, it is plausible that risk factors operating through hormonal mechanisms are differentially related to risk of such tumor subtypes. Using data from the Breast Cancer Surveillance Consortium, we explored associations between reproductive history and three breast cancer subtypes. Data on parity and age at first birth were collected from 743,623 women, 10,896 of whom were subsequently diagnosed with breast cancer. Cases were classified into three subtypes based on tumor maker expression: (1) ER positive (ER+, N=8,203), (2) ER negative/PR negative/HER2 positive (ER−/PR−/HER2+, N=288), or (3) ER-, PR-, and HER2-negative (triple-negative, N=645). Associations with reproductive history, evaluated using Cox regression, differed significantly across tumor subtypes. Nulliparity was most strongly associated with risk of ER+ breast cancer [hazard ratio (HR)=1.31, 95% confidence interval (CI): 1.23-1.39]; late age at first birth was most strongly associated with risk of ER-/PR-/HER2+ disease (HR=1.83, 95% CI: 1.31-2.56). Neither parity nor age at first birth was associated with triple-negative breast cancer. In contrast to ER+ and ER−/PR−/HER2+ subtypes, reproductive history does not appear to be a risk factor for triple-negative breast cancer. Springer Science+Business Media B.V., 2010 Breast cancer nationallicence Parity nationallicence Age at first birth nationallicence Triple-negative nationallicence Phipps Amanda Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave. N., M4-B402, 98109-1024, Seattle, WA, USA aut Buist Diana School of Public Health, University of Washington, Seattle, WA, USA aut Malone Kathleen Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave. N., M4-B402, 98109-1024, Seattle, WA, USA aut Barlow William School of Public Health, University of Washington, Seattle, WA, USA aut Porter Peggy Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave. N., M4-B402, 98109-1024, Seattle, WA, USA aut Kerlikowske Karla Departments of Medicine and Epidemiology and Biostatistics, University of California, San Francisco, CA, USA aut Li Christopher Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave. N., M4-B402, 98109-1024, Seattle, WA, USA aut Cancer Causes & Control Springer Netherlands 22/3(2011-03-01), 399-405 0957-5243 22:3<399 2011 22 10552 https://doi.org/10.1007/s10552-010-9709-0 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10552-010-9709-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Phipps Amanda Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave. N., M4-B402, 98109-1024, Seattle, WA, USA aut NATIONALLICENCE 700 1- Buist Diana School of Public Health, University of Washington, Seattle, WA, USA aut NATIONALLICENCE 700 1- Malone Kathleen Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave. N., M4-B402, 98109-1024, Seattle, WA, USA aut NATIONALLICENCE 700 1- Barlow William School of Public Health, University of Washington, Seattle, WA, USA aut NATIONALLICENCE 700 1- Porter Peggy Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave. N., M4-B402, 98109-1024, Seattle, WA, USA aut NATIONALLICENCE 700 1- Kerlikowske Karla Departments of Medicine and Epidemiology and Biostatistics, University of California, San Francisco, CA, USA aut NATIONALLICENCE 700 1- Li Christopher Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave. N., M4-B402, 98109-1024, Seattle, WA, USA aut NATIONALLICENCE 773 0- Cancer Causes & Control Springer Netherlands 22/3(2011-03-01), 399-405 0957-5243 22:3<399 2011 22 10552 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer