caa a22 4500 445315415 CHVBK 20180317142645.0 cr unu---uuuuu 170323e20110301xx s 000 0 eng 10.1007/s10552-010-9706-3 doi (NATIONALLICENCE)springer-10.1007/s10552-010-9706-3 Associations of circulating and dietary vitamin D with prostate cancer risk: a systematic review and dose-response meta-analysis [Elektronische Daten] [Rebecca Gilbert, Richard Martin, Rebecca Beynon, Ross Harris, Jelena Savovic, Luisa Zuccolo, Geertruida Bekkering, William Fraser, Jonathan Sterne, Chris Metcalfe] Objective: We systematically reviewed and meta-analyzed literature examining associations of vitamin D (dietary intake, circulating 25-hydroxy-vitamin-D (25(OH)D), and 1,25-dihydroxy-vitamin-D (1,25(OH)2D) concentrations) with prostate cancer. Methods: We searched over 24,000 papers from seven electronic databases (to October 2010) for exposures related to vitamin D. We conducted dose-response random-effects meta-analyses pooling the log odds ratio (OR) and 95% confidence intervals (CI) per change in natural units of each exposure. The I2 statistic quantified between-study variation due to heterogeneity. Results: Twenty-five papers were included. In prospective studies, the OR per 1,000IU increase in dietary intake was 1.14 (6 studies; CI: 0.99, 1.31; I 2=0%) for total prostate cancer and 0.93 (3 studies; 0.63, 1.39; I 2=25%) for aggressive prostate cancer. Five case-control studies examined dietary intake, but there was a high degree of inconsistency between studies (I 2=49%). The OR per 10ng/mL increase in 25(OH)D was 1.04 (14 studies; 0.99, 1.10; I 2=0%) for total prostate cancer and 0.98 (6 studies; 0.84, 1.15; I 2=32%) for aggressive prostate cancer. The OR per 10pg/mL increase in 1,25(OH)2D was 1.00 (7 studies; 0.87, 1.14; I 2=41%) for total prostate cancer and 0.86 (2 studies; 0.72, 1.02; I 2=0%) for aggressive prostate cancer. Conclusion: Published literature provides little evidence to support a major role of vitamin D in preventing prostate cancer or its progression. Springer Science+Business Media B.V., 2010 Vitamin D nationallicence Prostatic neoplasms nationallicence Review nationallicence Meta-analysis nationallicence Epidemiology nationallicence Gilbert Rebecca School of Social and Community Medicine, University of Bristol, Canynge Hall, 39 Whatley Road, BS8 2PS, Bristol, UK aut Martin Richard School of Social and Community Medicine, University of Bristol, Canynge Hall, 39 Whatley Road, BS8 2PS, Bristol, UK aut Beynon Rebecca School of Social and Community Medicine, University of Bristol, Canynge Hall, 39 Whatley Road, BS8 2PS, Bristol, UK aut Harris Ross Statistics Unit, Health Protection Agency, Centre for Infections, London, UK aut Savovic Jelena School of Social and Community Medicine, University of Bristol, Canynge Hall, 39 Whatley Road, BS8 2PS, Bristol, UK aut Zuccolo Luisa School of Social and Community Medicine, University of Bristol, Canynge Hall, 39 Whatley Road, BS8 2PS, Bristol, UK aut Bekkering Geertruida Department of General Practice, Katholieke Universiteit Leuven, Leuven, Belgium aut Fraser William Unit of Clinical Chemistry, School of Clinical Sciences, University of Liverpool, Liverpool, UK aut Sterne Jonathan School of Social and Community Medicine, University of Bristol, Canynge Hall, 39 Whatley Road, BS8 2PS, Bristol, UK aut Metcalfe Chris School of Social and Community Medicine, University of Bristol, Canynge Hall, 39 Whatley Road, BS8 2PS, Bristol, UK aut Cancer Causes & Control Springer Netherlands 22/3(2011-03-01), 319-340 0957-5243 22:3<319 2011 22 10552 https://doi.org/10.1007/s10552-010-9706-3 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10552-010-9706-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Gilbert Rebecca School of Social and Community Medicine, University of Bristol, Canynge Hall, 39 Whatley Road, BS8 2PS, Bristol, UK aut NATIONALLICENCE 700 1- Martin Richard School of Social and Community Medicine, University of Bristol, Canynge Hall, 39 Whatley Road, BS8 2PS, Bristol, UK aut NATIONALLICENCE 700 1- Beynon Rebecca School of Social and Community Medicine, University of Bristol, Canynge Hall, 39 Whatley Road, BS8 2PS, Bristol, UK aut NATIONALLICENCE 700 1- Harris Ross Statistics Unit, Health Protection Agency, Centre for Infections, London, UK aut NATIONALLICENCE 700 1- Savovic Jelena School of Social and Community Medicine, University of Bristol, Canynge Hall, 39 Whatley Road, BS8 2PS, Bristol, UK aut NATIONALLICENCE 700 1- Zuccolo Luisa School of Social and Community Medicine, University of Bristol, Canynge Hall, 39 Whatley Road, BS8 2PS, Bristol, UK aut NATIONALLICENCE 700 1- Bekkering Geertruida Department of General Practice, Katholieke Universiteit Leuven, Leuven, Belgium aut NATIONALLICENCE 700 1- Fraser William Unit of Clinical Chemistry, School of Clinical Sciences, University of Liverpool, Liverpool, UK aut NATIONALLICENCE 700 1- Sterne Jonathan School of Social and Community Medicine, University of Bristol, Canynge Hall, 39 Whatley Road, BS8 2PS, Bristol, UK aut NATIONALLICENCE 700 1- Metcalfe Chris School of Social and Community Medicine, University of Bristol, Canynge Hall, 39 Whatley Road, BS8 2PS, Bristol, UK aut NATIONALLICENCE 773 0- Cancer Causes & Control Springer Netherlands 22/3(2011-03-01), 319-340 0957-5243 22:3<319 2011 22 10552 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer