caa a22 4500 445315423 CHVBK 20180317142645.0 cr unu---uuuuu 170323e20110301xx s 000 0 eng 10.1007/s10552-010-9724-1 doi (NATIONALLICENCE)springer-10.1007/s10552-010-9724-1 ASIP genetic variants and the number of non-melanoma skin cancers [Elektronische Daten] [Wen Lin, Abrar Qureshi, Peter Kraft, Hongmei Nan, Qun Guo, Frank Hu, Majken Jensen, Jiali Han] Patients with primary non-melanoma skin cancers (NMSCs) tend to develop these cancers at multiple independent sites. We examined the genetic factors in the development of multiple NMSCs among Caucasian women with 28years of follow-up. We initially evaluated 19 SNPs in nine pigmentation genes with the number of NMSCs in 492 cases and 619 controls without a history of NMSC. We found nominal significant associations between two ASIP gene-related SNPs, rs1885120 and rs910873, and an ASIP haplotype (AH) (rs4911414 allele T and rs1015362 allele G) and an increased number of NMSCs, with p-values of 0.008, 0.01, and 0.01, respectively. We further evaluated these two SNPs and AH haplotype in three data sets. In a joint analysis with 1,507 cases and 4,335 controls, AH haplotype was independently associated with the number of NMSCs with odds ratio (OR) (95% confidence interval (CI)) of 1.45(1.25-1.68) (p-value=6.2E-07). The AH haplotype was associated with an increased risk of developing one NMSC (OR 1.32; 95% CI, 1.07-1.63). The OR increased to 1.45(1.18-1.78) for those with 2-4 NMSCs and 1.84(1.34-2.53) for those with at least five. The findings suggest that ASIP locus is associated with the number of NMSCs. Springer Science+Business Media B.V., 2011 SNP nationallicence Pigmentation gene nationallicence Non-melanoma skin cancer nationallicence ASIP nationallicence Lin Wen Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA aut Qureshi Abrar Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, 181 Longwood Avenue, 02115, Boston, MA, USA aut Kraft Peter Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA aut Nan Hongmei Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, 181 Longwood Avenue, 02115, Boston, MA, USA aut Guo Qun Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, 181 Longwood Avenue, 02115, Boston, MA, USA aut Hu Frank Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA aut Jensen Majken Department of Nutrition, Harvard School of Public Health, Boston, MA, USA aut Han Jiali Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA aut Cancer Causes & Control Springer Netherlands 22/3(2011-03-01), 495-501 0957-5243 22:3<495 2011 22 10552 https://doi.org/10.1007/s10552-010-9724-1 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10552-010-9724-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Lin Wen Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA aut NATIONALLICENCE 700 1- Qureshi Abrar Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, 181 Longwood Avenue, 02115, Boston, MA, USA aut NATIONALLICENCE 700 1- Kraft Peter Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA aut NATIONALLICENCE 700 1- Nan Hongmei Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, 181 Longwood Avenue, 02115, Boston, MA, USA aut NATIONALLICENCE 700 1- Guo Qun Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, 181 Longwood Avenue, 02115, Boston, MA, USA aut NATIONALLICENCE 700 1- Hu Frank Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA aut NATIONALLICENCE 700 1- Jensen Majken Department of Nutrition, Harvard School of Public Health, Boston, MA, USA aut NATIONALLICENCE 700 1- Han Jiali Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA aut NATIONALLICENCE 773 0- Cancer Causes & Control Springer Netherlands 22/3(2011-03-01), 495-501 0957-5243 22:3<495 2011 22 10552 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer