caa a22 4500 445315431 CHVBK 20180317142645.0 cr unu---uuuuu 170323e20110301xx s 000 0 eng 10.1007/s10552-010-9723-2 doi (NATIONALLICENCE)springer-10.1007/s10552-010-9723-2 Exposure to environmental tobacco smoke in childhood and incidence of cancer in adulthood in never smokers in the European prospective investigation into cancer and nutrition [Elektronische Daten] [Shu-Chun Chuang, Valentina Gallo, Dominique Michaud, Kim Overvad, Anne Tjønneland, Francoise Clavel-Chapelon, Isabelle Romieu, Kurt Straif, Domenico Palli, Valeria Pala, Rosario Tumino, Carlotta Sacerdote, Salvatore Panico, Petra Peeters, Eiliv Lund, Inger Gram, Jonas Manjer, Signe Borgquist, Elio Riboli, Paolo Vineis] The association between childhood environmental tobacco smoke (ETS) exposure and adult cancer risk is controversial; we examined this relationship in never smokers within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Over an average of 10years, 8,372 cases of cancer were diagnosed in 112,430 never smokers in EPIC. Childhood ETS was self-reported by participants at baseline, along with other lifestyle factors. Hazard ratios (HR) for ETS exposure in childhood and their 95% confidence intervals (CI) were estimated by Cox proportional hazards models stratified by age, sex, and study center and adjusted for education, alcohol drinking, body mass index, physical activity, non-alcoholic energy intake, fruit and vegetable intake, and adulthood ETS exposure. Models were further adjusted for reproductive factors for female cancers, for meat intake for digestive system cancers, and for diabetes status for pancreatic cancer. No association was observed between childhood ETS exposure and overall cancer risks (HR=0.97, 95% CI=0.92-1.02), and for selected sites. The only exception was pancreatic cancer, as previously reported by Vrieling et al., among those who had been exposed daily in childhood (overall HR=2.09, 95% CI=1.14-3.84). In conclusion, childhood ETS exposure might not be a major risk factor for common cancers in adulthood. Springer Science+Business Media B.V., 2011 Childhood ETS exposure nationallicence Adulthood cancers nationallicence Chuang Shu-Chun School of Public Health, Imperial College London, St Mary's Campus, Norfolk Place, W2 1PG, London, UK aut Gallo Valentina School of Public Health, Imperial College London, St Mary's Campus, Norfolk Place, W2 1PG, London, UK aut Michaud Dominique School of Public Health, Imperial College London, St Mary's Campus, Norfolk Place, W2 1PG, London, UK aut Overvad Kim Department of Epidemiology, School of Public Health, Aarhus University, Aarhus, Denmark aut Tjønneland Anne Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark aut Clavel-Chapelon Francoise INSERM, U1018, Centre for Research in Epidemiology and Population Health, Villejuif, France aut Romieu Isabelle International Agency for Research on Cancer, Lyon, France aut Straif Kurt International Agency for Research on Cancer, Lyon, France aut Palli Domenico Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute, ISPO, Florence, Italy aut Pala Valeria Department of Preventive and Predictive Medicine, Nutritional Epidemiology Unit, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy aut Tumino Rosario Ragusa Cancer Registry, Azienda Ospedaliera "Civile MP Arezzo”, Ragusa, Italy aut Sacerdote Carlotta HuGEF Foundation and CPO-Piemonte, Turin, Italy aut Panico Salvatore Department of Clinical and Experimental Medicine, Federico II University, Naples, Italy aut Peeters Petra Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, The Netherlands aut Lund Eiliv Institute of Community Medicine, University of Tromsø, Tromsø, Norway aut Gram Inger Institute of Community Medicine, University of Tromsø, Tromsø, Norway aut Manjer Jonas Department of Surgery, Skåne University Hospital Malmö, Lund University, Malmö, Sweden aut Borgquist Signe Department of Oncology, Skåne University Hospital Lund, Lund University, Lund, Sweden aut Riboli Elio School of Public Health, Imperial College London, St Mary's Campus, Norfolk Place, W2 1PG, London, UK aut Vineis Paolo School of Public Health, Imperial College London, St Mary's Campus, Norfolk Place, W2 1PG, London, UK aut Cancer Causes & Control Springer Netherlands 22/3(2011-03-01), 487-494 0957-5243 22:3<487 2011 22 10552 https://doi.org/10.1007/s10552-010-9723-2 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10552-010-9723-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Chuang Shu-Chun School of Public Health, Imperial College London, St Mary's Campus, Norfolk Place, W2 1PG, London, UK aut NATIONALLICENCE 700 1- Gallo Valentina School of Public Health, Imperial College London, St Mary's Campus, Norfolk Place, W2 1PG, London, UK aut NATIONALLICENCE 700 1- Michaud Dominique School of Public Health, Imperial College London, St Mary's Campus, Norfolk Place, W2 1PG, London, UK aut NATIONALLICENCE 700 1- Overvad Kim Department of Epidemiology, School of Public Health, Aarhus University, Aarhus, Denmark aut NATIONALLICENCE 700 1- Tjønneland Anne Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark aut NATIONALLICENCE 700 1- Clavel-Chapelon Francoise INSERM, U1018, Centre for Research in Epidemiology and Population Health, Villejuif, France aut NATIONALLICENCE 700 1- Romieu Isabelle International Agency for Research on Cancer, Lyon, France aut NATIONALLICENCE 700 1- Straif Kurt International Agency for Research on Cancer, Lyon, France aut NATIONALLICENCE 700 1- Palli Domenico Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute, ISPO, Florence, Italy aut NATIONALLICENCE 700 1- Pala Valeria Department of Preventive and Predictive Medicine, Nutritional Epidemiology Unit, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy aut NATIONALLICENCE 700 1- Tumino Rosario Ragusa Cancer Registry, Azienda Ospedaliera "Civile MP Arezzo”, Ragusa, Italy aut NATIONALLICENCE 700 1- Sacerdote Carlotta HuGEF Foundation and CPO-Piemonte, Turin, Italy aut NATIONALLICENCE 700 1- Panico Salvatore Department of Clinical and Experimental Medicine, Federico II University, Naples, Italy aut NATIONALLICENCE 700 1- Peeters Petra Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, The Netherlands aut NATIONALLICENCE 700 1- Lund Eiliv Institute of Community Medicine, University of Tromsø, Tromsø, Norway aut NATIONALLICENCE 700 1- Gram Inger Institute of Community Medicine, University of Tromsø, Tromsø, Norway aut NATIONALLICENCE 700 1- Manjer Jonas Department of Surgery, Skåne University Hospital Malmö, Lund University, Malmö, Sweden aut NATIONALLICENCE 700 1- Borgquist Signe Department of Oncology, Skåne University Hospital Lund, Lund University, Lund, Sweden aut NATIONALLICENCE 700 1- Riboli Elio School of Public Health, Imperial College London, St Mary's Campus, Norfolk Place, W2 1PG, London, UK aut NATIONALLICENCE 700 1- Vineis Paolo School of Public Health, Imperial College London, St Mary's Campus, Norfolk Place, W2 1PG, London, UK aut NATIONALLICENCE 773 0- Cancer Causes & Control Springer Netherlands 22/3(2011-03-01), 487-494 0957-5243 22:3<487 2011 22 10552 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer