caa a22 4500 445315458 CHVBK 20180317142645.0 cr unu---uuuuu 170323e20111001xx s 000 0 eng 10.1007/s10552-011-9809-5 doi (NATIONALLICENCE)springer-10.1007/s10552-011-9809-5 Mediators and moderators of the effects of a year-long exercise intervention on endogenous sex hormones in postmenopausal women [Elektronische Daten] [Christine Friedenreich, Heather Neilson, Christy Woolcott, Qinggang Wang, Yutaka Yasui, Rollin Brant, Frank Stanczyk, Kristin Campbell, Kerry Courneya] Objective: To identify factors that mediate or moderate the effects of exercise on postmenopausal sex hormone concentrations. Methods: Postmenopausal women were randomized to 12months of aerobic exercise for 200min/week (n=160) or to a control group (n=160). Intention-to-treat analyses were performed using general linear models with sex hormone concentrations at 6 and 12months as the outcome. Mediation by adiposity and insulin was investigated by examining changes in effect estimates after adjustment for changes in these factors over 12months. Moderation was studied as the interaction between group assignment and eight baseline characteristics. Results: Intervention effects on sex hormone-binding globulin (SHBG) and estradiol changes were attenuated with adjustment for change in overall body fat, while there was less attenuation adjusting for intra-abdominal fat change. Intervention effects on SHBG levels were unaffected by adjustment for insulin change. Significant interactions were identified between treatment and physical fitness (for SHBG and testosterone) and age (for testosterone), implying subgroup differences in intervention effect. Conclusions: Our data suggest that overall fat loss partially mediated exercise-induced changes in estradiol and SHBG concentrations. No previous RCT in postmenopausal women has studied moderators of exercise-induced sex hormone changes; therefore, future studies are needed to corroborate our results. The Author(s), 2011 Exercise nationallicence Gonadal steroid hormones nationallicence Sex hormone-binding globulin nationallicence Randomized controlled trial nationallicence Breast neoplasms nationallicence Friedenreich Christine Department of Population Health Research, Alberta Health Services-Cancer Care, T2N 4N2, Calgary, AB, Canada aut Neilson Heather Department of Population Health Research, Alberta Health Services-Cancer Care, T2N 4N2, Calgary, AB, Canada aut Woolcott Christy Departments of Obstetrics and Gynaecology and Pediatrics, Dalhousie University, Halifax, NS, Canada aut Wang Qinggang Department of Population Health Research, Alberta Health Services-Cancer Care, T2N 4N2, Calgary, AB, Canada aut Yasui Yutaka Department of Public Health Sciences, University of Alberta, Edmonton, AB, Canada aut Brant Rollin Department of Statistics, University of British Columbia, Vancouver, BC, Canada aut Stanczyk Frank Department of Obstetrics and Gynecology, University of Southern California, Keck School of Medicine, Los Angeles, CA, USA aut Campbell Kristin Department of Physical Therapy, University of British Columbia, Vancouver, BC, Canada aut Courneya Kerry Faculty of Physical Education and Recreation, University of Alberta, Edmonton, AB, Canada aut Cancer Causes & Control Springer Netherlands 22/10(2011-10-01), 1365-1373 0957-5243 22:10<1365 2011 22 10552 https://doi.org/10.1007/s10552-011-9809-5 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10552-011-9809-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Friedenreich Christine Department of Population Health Research, Alberta Health Services-Cancer Care, T2N 4N2, Calgary, AB, Canada aut NATIONALLICENCE 700 1- Neilson Heather Department of Population Health Research, Alberta Health Services-Cancer Care, T2N 4N2, Calgary, AB, Canada aut NATIONALLICENCE 700 1- Woolcott Christy Departments of Obstetrics and Gynaecology and Pediatrics, Dalhousie University, Halifax, NS, Canada aut NATIONALLICENCE 700 1- Wang Qinggang Department of Population Health Research, Alberta Health Services-Cancer Care, T2N 4N2, Calgary, AB, Canada aut NATIONALLICENCE 700 1- Yasui Yutaka Department of Public Health Sciences, University of Alberta, Edmonton, AB, Canada aut NATIONALLICENCE 700 1- Brant Rollin Department of Statistics, University of British Columbia, Vancouver, BC, Canada aut NATIONALLICENCE 700 1- Stanczyk Frank Department of Obstetrics and Gynecology, University of Southern California, Keck School of Medicine, Los Angeles, CA, USA aut NATIONALLICENCE 700 1- Campbell Kristin Department of Physical Therapy, University of British Columbia, Vancouver, BC, Canada aut NATIONALLICENCE 700 1- Courneya Kerry Faculty of Physical Education and Recreation, University of Alberta, Edmonton, AB, Canada aut NATIONALLICENCE 773 0- Cancer Causes & Control Springer Netherlands 22/10(2011-10-01), 1365-1373 0957-5243 22:10<1365 2011 22 10552 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer