caa a22 4500 445315466 CHVBK 20180317142645.0 cr unu---uuuuu 170323e20111001xx s 000 0 eng 10.1007/s10552-011-9821-9 doi (NATIONALLICENCE)springer-10.1007/s10552-011-9821-9 Birth size and breast cancer risk among young California-born women [Elektronische Daten] [Susan Hurley, Debbie Goldberg, Julie Von Behren, Thu Quach, Michael Layefsky, Peggy Reynolds] Objective: Evaluate the risk of breast cancer associated with birth size among young California-born women. Methods: Invasive breast cancer cases diagnosed 1988-2004 among women born in California during the 1960s were identified from the California Cancer Registry. Breast cancer cases (n=3,712) were linked to their California birth records. Controls (n=8,615) were randomly selected from California birth records for women, frequency matched to cases by birth year. Odds ratios (ORs) and 95% confidence intervals (95% CI) were estimated from unconditional logistic regression. Results: The adjusted OR for breast cancer associated with the highest category of birth weight (≥4,000g) was 1.12 (95% CI 0.89-1.41), p-trend=0.02. The adjusted OR for the highest category of birth length (>20 inches) was 1.13 (95% CI 1.02-1.25), p-trend=0.02. These relationships appeared to be confined to cases with estrogen receptor positive (ER+) tumors (p-trend ≤0.01) or progesterone receptor positive (PR+) tumors (p-trend ≤0.02). No significant associations were found among cases with ER or PR negative tumors. Conclusions: Our results confirm previous findings of elevated breast cancer risk associated with increases in birth size. These risks may be confined to ER+ and PR+ tumors, highlighting the potential mechanistic role of sex steroid hormonal pathways. Springer Science+Business Media B.V., 2011 Breast cancer nationallicence Premenopausal nationallicence Risk factors nationallicence Epidemiology nationallicence Perinatal nationallicence Hurley Susan Department of Research, Cancer Prevention Institute of California, 2001 Center Street, Suite 700, 94704, Berkeley, CA, USA aut Goldberg Debbie Department of Research, Cancer Prevention Institute of California, 2001 Center Street, Suite 700, 94704, Berkeley, CA, USA aut Von Behren Julie Department of Research, Cancer Prevention Institute of California, 2001 Center Street, Suite 700, 94704, Berkeley, CA, USA aut Quach Thu Department of Research, Cancer Prevention Institute of California, 2001 Center Street, Suite 700, 94704, Berkeley, CA, USA aut Layefsky Michael Department of Research, Cancer Prevention Institute of California, 2001 Center Street, Suite 700, 94704, Berkeley, CA, USA aut Reynolds Peggy Department of Research, Cancer Prevention Institute of California, 2001 Center Street, Suite 700, 94704, Berkeley, CA, USA aut Cancer Causes & Control Springer Netherlands 22/10(2011-10-01), 1461-1470 0957-5243 22:10<1461 2011 22 10552 https://doi.org/10.1007/s10552-011-9821-9 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10552-011-9821-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Hurley Susan Department of Research, Cancer Prevention Institute of California, 2001 Center Street, Suite 700, 94704, Berkeley, CA, USA aut NATIONALLICENCE 700 1- Goldberg Debbie Department of Research, Cancer Prevention Institute of California, 2001 Center Street, Suite 700, 94704, Berkeley, CA, USA aut NATIONALLICENCE 700 1- Von Behren Julie Department of Research, Cancer Prevention Institute of California, 2001 Center Street, Suite 700, 94704, Berkeley, CA, USA aut NATIONALLICENCE 700 1- Quach Thu Department of Research, Cancer Prevention Institute of California, 2001 Center Street, Suite 700, 94704, Berkeley, CA, USA aut NATIONALLICENCE 700 1- Layefsky Michael Department of Research, Cancer Prevention Institute of California, 2001 Center Street, Suite 700, 94704, Berkeley, CA, USA aut NATIONALLICENCE 700 1- Reynolds Peggy Department of Research, Cancer Prevention Institute of California, 2001 Center Street, Suite 700, 94704, Berkeley, CA, USA aut NATIONALLICENCE 773 0- Cancer Causes & Control Springer Netherlands 22/10(2011-10-01), 1461-1470 0957-5243 22:10<1461 2011 22 10552 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer