caa a22 4500 445315474 CHVBK 20180317142645.0 cr unu---uuuuu 170323e20111001xx s 000 0 eng 10.1007/s10552-011-9819-3 doi (NATIONALLICENCE)springer-10.1007/s10552-011-9819-3 The association between antihypertensive drug use and incidence of prostate cancer in Finland: a population-based case-control study [Elektronische Daten] [Kimmo Kemppainen, Teuvo Tammela, Anssi Auvinen, Teemu Murtola] Some studies have suggested that use of antihypertensive drugs could decrease prostate cancer risk. We evaluated this association at the population level. All prostate cancer cases in Finland during 1995-2002 and matched controls (24,657 case-control pairs) were identified from the Finnish Cancer Registry and the Population Register Center, respectively. Detailed information on antihypertensive drug purchases was obtained from a national prescription database. Data were analyzed using multivariable-adjusted conditional logistic regression model. Ever use of antihypertensive drugs was associated with marginally elevated overall prostate cancer risk (OR 1.16; 95% CI, 1.12-1.21). Risk of advanced prostate cancer did not differ from the nonusers (OR 1.08, 95% CI 0.98-1.18). The risk increase was observed constantly in all classes of antihypertensive drugs. Our large population-based study generally does not support decreased risk of prostate cancer among antihypertensive drug users. Conversely, an increased overall prostate cancer risk was observed. The association being similar for all drug groups suggests that it is probably caused by a systematic difference between medication users and nonusers, such as differing PSA testing activity. Springer Science+Business Media B.V., 2011 Antihypertensive drugs nationallicence Case-control nationallicence Prostatic neoplasms nationallicence Kemppainen Kimmo School of Medicine, University of Tampere, 33014, Tampere, Finland aut Tammela Teuvo School of Medicine, University of Tampere, 33014, Tampere, Finland aut Auvinen Anssi School of Health Sciences, University of Tampere, Tampere, Finland aut Murtola Teemu School of Medicine, University of Tampere, 33014, Tampere, Finland aut Cancer Causes & Control Springer Netherlands 22/10(2011-10-01), 1445-1452 0957-5243 22:10<1445 2011 22 10552 https://doi.org/10.1007/s10552-011-9819-3 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10552-011-9819-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kemppainen Kimmo School of Medicine, University of Tampere, 33014, Tampere, Finland aut NATIONALLICENCE 700 1- Tammela Teuvo School of Medicine, University of Tampere, 33014, Tampere, Finland aut NATIONALLICENCE 700 1- Auvinen Anssi School of Health Sciences, University of Tampere, Tampere, Finland aut NATIONALLICENCE 700 1- Murtola Teemu School of Medicine, University of Tampere, 33014, Tampere, Finland aut NATIONALLICENCE 773 0- Cancer Causes & Control Springer Netherlands 22/10(2011-10-01), 1445-1452 0957-5243 22:10<1445 2011 22 10552 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer