caa a22 4500 445315490 CHVBK 20180317142645.0 cr unu---uuuuu 170323e20111001xx s 000 0 eng 10.1007/s10552-011-9814-8 doi (NATIONALLICENCE)springer-10.1007/s10552-011-9814-8 Reproductive and menstrual factors and risk of ductal carcinoma in situ of the breast in a cohort of postmenopausal women [Elektronische Daten] [Geoffrey Kabat, Mimi Kim, Nancy Woods, Laurel Habel, Catherine Messina, Jean Wactawski-Wende, Marcia Stefanick, Rowan Chlebowski, Sylvia Wassertheil-Smoller, Thomas Rohan] Purpose: The contribution of menstrual and reproductive factors to risk of ductal carcinoma (DCIS) of the breast is poorly understood. Methods: The association between menstrual and reproductive factors and subsequent DCIS risk was examined in Women's Health Initiative (WHI) clinical trial participants, in which mammography was protocol mandated. The cohort consisted of 64,060 women, among whom 664 cases of DCIS were ascertained over a median follow-up of 12.0years. Cox proportional hazards models were used to estimate hazard ratios (HR) and 95% confidence intervals (95% CI). Results: After adjustment for covariates, only older age at menopause (HR≥55 vs. 45-54 : 1.39, 95% CI 1.08-1.79) was significantly associated with risk; however, greater parity (HR≥5 live births vs. 0: 0.70, 95% CI 0.47-1.03), among parous women, and age at first live birth (HR≥30years relative to <20years: 1.32, 95% CI 0.92-1.90) were of borderline significance. Age at menarche and months of breast-feeding were not associated with risk. Associations did not differ between high- and low-/moderate-grade DCIS, or by level of body mass index or family history of breast cancer; however, there was a suggestion that the associations of age at menopause, parity, and age at first live birth were limited to women who had ever used hormone therapy. Conclusions: Findings from this large cohort of postmenopausal women suggest that age at menopause, and possibly, age at first live birth, and parity are associated with risk of DCIS, whereas age at menarche and duration of breast-feeding are not. Springer Science+Business Media B.V., 2011 Breast cancer nationallicence Ductal carcinoma in situ (DCIS) nationallicence Reproductive factors nationallicence Menstrual factors nationallicence Grade nationallicence Natural history nationallicence Hormone therapy nationallicence Mammographic screening nationallicence Kabat Geoffrey Department of Epidemiology and Population Health, Albert Einstein College of Medicine, 10461, Bronx, NY, USA aut Kim Mimi Department of Epidemiology and Population Health, Albert Einstein College of Medicine, 10461, Bronx, NY, USA aut Woods Nancy Biobehavioral Nursing and Health Systems, School of Nursing, University of Washington, Seattle, WA, USA aut Habel Laurel Division of Research, Kaiser Permanente, Oakland, CA, USA aut Messina Catherine Department of Preventive Medicine, School of Medicine, State University of New York at Stony Brook, Stony Brook, NY, USA aut Wactawski-Wende Jean Department of Social and Preventive Medicine, School of Public Health and Health Professions, University at Buffalo, Buffalo, NY, USA aut Stefanick Marcia Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA aut Chlebowski Rowan Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA aut Wassertheil-Smoller Sylvia Department of Epidemiology and Population Health, Albert Einstein College of Medicine, 10461, Bronx, NY, USA aut Rohan Thomas Department of Epidemiology and Population Health, Albert Einstein College of Medicine, 10461, Bronx, NY, USA aut Cancer Causes & Control Springer Netherlands 22/10(2011-10-01), 1415-1424 0957-5243 22:10<1415 2011 22 10552 https://doi.org/10.1007/s10552-011-9814-8 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10552-011-9814-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kabat Geoffrey Department of Epidemiology and Population Health, Albert Einstein College of Medicine, 10461, Bronx, NY, USA aut NATIONALLICENCE 700 1- Kim Mimi Department of Epidemiology and Population Health, Albert Einstein College of Medicine, 10461, Bronx, NY, USA aut NATIONALLICENCE 700 1- Woods Nancy Biobehavioral Nursing and Health Systems, School of Nursing, University of Washington, Seattle, WA, USA aut NATIONALLICENCE 700 1- Habel Laurel Division of Research, Kaiser Permanente, Oakland, CA, USA aut NATIONALLICENCE 700 1- Messina Catherine Department of Preventive Medicine, School of Medicine, State University of New York at Stony Brook, Stony Brook, NY, USA aut NATIONALLICENCE 700 1- Wactawski-Wende Jean Department of Social and Preventive Medicine, School of Public Health and Health Professions, University at Buffalo, Buffalo, NY, USA aut NATIONALLICENCE 700 1- Stefanick Marcia Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA aut NATIONALLICENCE 700 1- Chlebowski Rowan Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA aut NATIONALLICENCE 700 1- Wassertheil-Smoller Sylvia Department of Epidemiology and Population Health, Albert Einstein College of Medicine, 10461, Bronx, NY, USA aut NATIONALLICENCE 700 1- Rohan Thomas Department of Epidemiology and Population Health, Albert Einstein College of Medicine, 10461, Bronx, NY, USA aut NATIONALLICENCE 773 0- Cancer Causes & Control Springer Netherlands 22/10(2011-10-01), 1415-1424 0957-5243 22:10<1415 2011 22 10552 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer