caa a22 4500 445315504 CHVBK 20180317142645.0 cr unu---uuuuu 170323e20111001xx s 000 0 eng 10.1007/s10552-011-9818-4 doi (NATIONALLICENCE)springer-10.1007/s10552-011-9818-4 Non-Hodgkin lymphoma and gluten-sensitive enteropathy: estimate of risk using meta-analyses [Elektronische Daten] [Eleanor Kane, Rob Newton, Eve Roman] Objectives: Gluten-sensitive enteropathy, including coeliac disease and dermatitis herpetiformis, is associated with non-Hodgkin lymphoma (NHL), and particularly enteropathy-associated T-cell lymphoma (EATCL). We conducted a meta-analysis to quantify the association. Methods: Fifty-four risk estimates (range 0.28-300) were pooled using random-effects meta-analysis. Potential sources of variation were examined using sensitivity analyses and meta-regression. Results: Thirty-one estimates with gluten-sensitive enteropathy diagnosed by serology then biopsy, serology alone, or recorded in medical notes accounted for half the variation in risks, giving a pooled estimate of 4.42 (95% confidence interval (CI) 3.72-5.26, I 2 =0%). Men and women had similar pooled risks. Risks were largest when these conditions were diagnosed using biopsy and lowest when self-reported. Study design, comparison population, geography or gluten-sensitive enteropathy type explained less of the variation. EATCL estimates ranged from 6 to 200; an association with diffuse large B-cell lymphoma (DLBCL) was also observed (pooled risk estimate=1.97, 95% CI 1.23-3.15). Conclusions: Where gluten-sensitive enteropathy was diagnosed using modern techniques, NHL risk was increased fourfold. At this level, one in 2,000 persons with gluten-sensitive enteropathy develops NHL each year. In addition to EATCL, DLBCL and possibly other subtypes may be linked to these conditions, and these weaker associations could be investigated in large population-based cohorts with biological samples. Springer Science+Business Media B.V., 2011 Non-Hodgkin lymphoma nationallicence Gluten-sensitive enteropathy nationallicence Coeliac disease nationallicence Dermatitis herpetiformis nationallicence Meta-analysis nationallicence AgA : Antigliadin antibodies nationallicence CI : Confidence interval nationallicence DH : Dermatitis herpetiformis nationallicence DLBCL : Diffuse large B-cell lymphoma nationallicence EMA : Endomysial antibodies nationallicence EATCL : Enteropathy-associated T-cell lymphoma nationallicence IgA : Immunoglobulin antibodies nationallicence NHL : Non-Hodgkin lymphoma nationallicence PI : Predictive interval nationallicence RCD : Refractory coeliac disease nationallicence tTGA : Tissue transglutaminase antibodies nationallicence Kane Eleanor Epidemiology and Genetics Unit, Department of Health Sciences, University of York, Seebohm Rowntree Building, Heslington, YO10 5DD, York, UK aut Newton Rob Epidemiology and Genetics Unit, Department of Health Sciences, University of York, Seebohm Rowntree Building, Heslington, YO10 5DD, York, UK aut Roman Eve Epidemiology and Genetics Unit, Department of Health Sciences, University of York, Seebohm Rowntree Building, Heslington, YO10 5DD, York, UK aut Cancer Causes & Control Springer Netherlands 22/10(2011-10-01), 1435-1444 0957-5243 22:10<1435 2011 22 10552 https://doi.org/10.1007/s10552-011-9818-4 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10552-011-9818-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kane Eleanor Epidemiology and Genetics Unit, Department of Health Sciences, University of York, Seebohm Rowntree Building, Heslington, YO10 5DD, York, UK aut NATIONALLICENCE 700 1- Newton Rob Epidemiology and Genetics Unit, Department of Health Sciences, University of York, Seebohm Rowntree Building, Heslington, YO10 5DD, York, UK aut NATIONALLICENCE 700 1- Roman Eve Epidemiology and Genetics Unit, Department of Health Sciences, University of York, Seebohm Rowntree Building, Heslington, YO10 5DD, York, UK aut NATIONALLICENCE 773 0- Cancer Causes & Control Springer Netherlands 22/10(2011-10-01), 1435-1444 0957-5243 22:10<1435 2011 22 10552 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer