caa a22 4500 445315512 CHVBK 20180317142645.0 cr unu---uuuuu 170323e20111001xx s 000 0 eng 10.1007/s10552-011-9812-x doi (NATIONALLICENCE)springer-10.1007/s10552-011-9812-x Risk of lung cancer in relation to contiguous windows of endotoxin exposure among female textile workers in Shanghai [Elektronische Daten] [Ilir Agalliu, Sadie Costello, Katie Applebaum, Roberta Ray, George Astrakianakis, Dao Gao, David Thomas, Harvey Checkoway, Ellen Eisen] Objective: Exposure to endotoxin has been consistently associated with a reduced risk of lung cancer. However, there is a paucity of information regarding temporal aspects of this relationship. The objective of this study was to investigate the associations between contiguous windows of endotoxin exposure and risk of lung cancer. Methods: Data were reanalyzed from a case-cohort study (602 cases, 3,038 subcohort) of female textile workers in Shanghai, China. Cumulative endotoxin exposure was partitioned into two windows: ≥20 and <20years before risk. Exposure-response relations were examined using categorical and non-linear (semi-parametric) models, accounting for confounding by previous exposure windows. Results: There was an inverse trend of decreasing risk of lung cancer associated with increasing levels of endotoxin exposure ≥20years before risk (p trend=0.02). Women in the highest two categories of cumulative exposures had hazard ratios of 0.78 (95% CI 0.60-1.03) and 0.77 (95% CI 0.58-1.02) for lung cancer, respectively, in comparison with unexposed textile workers. There was, however, a weaker association and not statistically significant between lung cancer and endotoxin exposure accumulated in the more recent window (<20years before risk). Conclusion: Results provide further evidence that endotoxin exposure that occurred 20years or more before risk confers the strongest protection against lung cancer, indicating a possible early anti-carcinogenic effect. Further studies are needed to better understand the underlying biological mechanisms for this effect. Springer Science+Business Media B.V., 2011 Lung cancer nationallicence Endotoxin nationallicence Exposure windows nationallicence Exposure-response models nationallicence Latency nationallicence Case-cohort analysis nationallicence Non-parametric models nationallicence Splines nationallicence Agalliu Ilir Department of Epidemiology and Population Health, Albert Einstein College of Medicine, 1300 Morris Park Ave., Belfer Bldg Room 1315-B, Bronx, NY, USA aut Costello Sadie Department of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA, USA aut Applebaum Katie Department of Epidemiology, School of Public Health, Boston University, Boston, MA, USA aut Ray Roberta Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA aut Astrakianakis George School of Population and Public Health, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada aut Gao Dao Zhong Shan Hospital Cancer Center, Shanghai, China aut Thomas David Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA aut Checkoway Harvey Department of Epidemiology, University of Washington, Seattle, WA, USA aut Eisen Ellen Department of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA, USA aut Cancer Causes & Control Springer Netherlands 22/10(2011-10-01), 1397-1404 0957-5243 22:10<1397 2011 22 10552 https://doi.org/10.1007/s10552-011-9812-x text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10552-011-9812-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Agalliu Ilir Department of Epidemiology and Population Health, Albert Einstein College of Medicine, 1300 Morris Park Ave., Belfer Bldg Room 1315-B, Bronx, NY, USA aut NATIONALLICENCE 700 1- Costello Sadie Department of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA, USA aut NATIONALLICENCE 700 1- Applebaum Katie Department of Epidemiology, School of Public Health, Boston University, Boston, MA, USA aut NATIONALLICENCE 700 1- Ray Roberta Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA aut NATIONALLICENCE 700 1- Astrakianakis George School of Population and Public Health, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada aut NATIONALLICENCE 700 1- Gao Dao Zhong Shan Hospital Cancer Center, Shanghai, China aut NATIONALLICENCE 700 1- Thomas David Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA aut NATIONALLICENCE 700 1- Checkoway Harvey Department of Epidemiology, University of Washington, Seattle, WA, USA aut NATIONALLICENCE 700 1- Eisen Ellen Department of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA, USA aut NATIONALLICENCE 773 0- Cancer Causes & Control Springer Netherlands 22/10(2011-10-01), 1397-1404 0957-5243 22:10<1397 2011 22 10552 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer