caa a22 4500 445315520 CHVBK 20180317142645.0 cr unu---uuuuu 170323e20111001xx s 000 0 eng 10.1007/s10552-011-9808-6 doi (NATIONALLICENCE)springer-10.1007/s10552-011-9808-6 Inverse association between eczema and meningioma: a meta-analysis [Elektronische Daten] [Mei Wang, Chao Chen, Jintao Qu, Tao Xu, Yicheng Lu, Juxiang Chen, Shenhong Wu] Background and purpose: The pathogenesis of primary brain tumors may be related to immune response. Prior studies have shown a strong association between allergy and glioma; however, so far no significant association has been established between allergy and meningioma. Here, we conducted a meta-analysis of published studies to investigate the association of meningioma with the overall and specific allergic conditions. Methods: PubMed, EMBASE database, and Cochrane Library were searched for pertinent citations published between January 1979 and October 2009. We used the following searching strategy (brain tumor [Text Word] OR meningioma [Text Word]) AND (allergy [Text Word] OR atopy [Text Word] OR asthma [Text Word] OR eczema [Text Word] OR hay fever [Text Word]) to search for relevant studies. Random effect model was used to estimate the association between allergic conditions and meningioma. Result: A total of 7 studies (5 case-control studies and 2 cohort studies) were included in the analysis, involving 54,391 participants, of whom 2,656 had meningioma. When compared to non-allergic conditions, the pooled odds ratio (OR) with any allergic conditions for meningioma was 0.91 (95% CI: 0.79-1.04, p=0.163), suggesting that there is no significant association between meningioma and allergic conditions. Interestingly, further analysis showed that eczema had significantly inverse association with meningioma (OR, 0.75; 95% CI: 0.65-0.87, p<0.05). On the other hand, no significant association was found for asthma (OR, 0.88; 95% CI: 0.75-1.04, p=0.126) and hay fever (OR, 0.90; 95% CI: 0.79-1.03, p=0.137). Conclusion: In conclusion, there was a significantly negative association between eczema and meningioma, suggesting that eczema may reduce the risk of meningioma. Although it was not statistically significant association between meningioma and other specific allergic conditions such as asthma and hay fever, further studies with large sample size may be needed to determine its relationship. Springer Science+Business Media B.V., 2011 Meningioma nationallicence Allergy nationallicence Atopy nationallicence Eczema nationallicence Asthma nationallicence Hay fever nationallicence Risk factor nationallicence Meta-analysis nationallicence Wang Mei Changzheng Hospital, Second Military Medical University, 200433, Shanghai, China aut Chen Chao Changzheng Hospital, Second Military Medical University, 200433, Shanghai, China aut Qu Jintao Changzheng Hospital, Second Military Medical University, 200433, Shanghai, China aut Xu Tao Changzheng Hospital, Second Military Medical University, 200433, Shanghai, China aut Lu Yicheng Department of Neurosurgery, Changzheng Hospital, Second Military Medical University, 200003, Shanghai, China aut Chen Juxiang Department of Neurosurgery, Changzheng Hospital, Second Military Medical University, 200003, Shanghai, China aut Wu Shenhong Division of Hematology and Oncology, Department of Medicine, Stony Brook University Cancer Center, 11794, New York, NY, USA aut Cancer Causes & Control Springer Netherlands 22/10(2011-10-01), 1355-1363 0957-5243 22:10<1355 2011 22 10552 https://doi.org/10.1007/s10552-011-9808-6 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10552-011-9808-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Wang Mei Changzheng Hospital, Second Military Medical University, 200433, Shanghai, China aut NATIONALLICENCE 700 1- Chen Chao Changzheng Hospital, Second Military Medical University, 200433, Shanghai, China aut NATIONALLICENCE 700 1- Qu Jintao Changzheng Hospital, Second Military Medical University, 200433, Shanghai, China aut NATIONALLICENCE 700 1- Xu Tao Changzheng Hospital, Second Military Medical University, 200433, Shanghai, China aut NATIONALLICENCE 700 1- Lu Yicheng Department of Neurosurgery, Changzheng Hospital, Second Military Medical University, 200003, Shanghai, China aut NATIONALLICENCE 700 1- Chen Juxiang Department of Neurosurgery, Changzheng Hospital, Second Military Medical University, 200003, Shanghai, China aut NATIONALLICENCE 700 1- Wu Shenhong Division of Hematology and Oncology, Department of Medicine, Stony Brook University Cancer Center, 11794, New York, NY, USA aut NATIONALLICENCE 773 0- Cancer Causes & Control Springer Netherlands 22/10(2011-10-01), 1355-1363 0957-5243 22:10<1355 2011 22 10552 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer