caa a22 4500 445315539 CHVBK 20180317142645.0 cr unu---uuuuu 170323e20111001xx s 000 0 eng 10.1007/s10552-011-9811-y doi (NATIONALLICENCE)springer-10.1007/s10552-011-9811-y Retinol, vitamins A, C, and E and breast cancer risk: a meta-analysis and meta-regression [Elektronische Daten] [Hu Fulan, Jiang Changxing, Wang Baina, Zhang Wencui, Lin Chunqing, Wang Fan, Li Dandan, Sun Dianjun, Wang Tong, Pang Da, Zhao Yashuang] Objective: To comprehensively summarize the associations between retinol, vitamins A, C, and E and breast cancer, and quantitatively estimate their dose-response relationships. Methods: We searched PubMed, Embase, and Cochrane databases (from January 1982 to 15 March 2011) and the references of the relevant articles in English with sufficient information to estimate relative risk or odds ratio and the 95% confidence intervals, and comparable categories of vitamins. Two reviewers independently extracted data using a standardized form, with any discrepancy adjudicated by the third reviewer. Results: Overall, 51 studies met the inclusion criteria. Comparing the highest with the lowest intake, total vitamin A intake reduced the breast cancer risk by 17% (pooled OR=0.83, 95% CI: 0.78-0.88). Further subgroup analysis based on study design did not change the significant reduction. Although the dietary vitamin A, dietary vitamin E, and total vitamin E intake all reduced breast cancer risk significantly when data from all studies were pooled, the results became nonsignificant when data from cohort studies were pooled. The significant association between total retinol intake and breast cancer in all studies became nonsignificant in case-control studies but remain significant in cohort studies. No significant dose-response relationship was observed in the higher intake of these vitamins with reduced breast cancer risk. Conclusions: Our results indicate that both the total intake of vitamin A and retinol could reduce breast cancer risk. However, associations between other vitamins and breast cancer seem to be limited. Springer Science+Business Media B.V., 2011 Retinol nationallicence Vitamin A nationallicence Vitamin C nationallicence Vitamin E nationallicence Breast cancer nationallicence Meta-analysis nationallicence Fulan Hu Department of Epidemiology, Public Health College, Harbin Medical University, 157, Baojian Street, Nangang District, Harbin, Heilongjiang, People's Republic of China aut Changxing Jiang Center for Endemic Disease Control, Harbin Medical University, Harbin, Heilongjiang Province, People's Republic of China aut Baina Wang Department of Epidemiology, Public Health College, Harbin Medical University, 157, Baojian Street, Nangang District, Harbin, Heilongjiang, People's Republic of China aut Wencui Zhang Department of Epidemiology, Public Health College, Harbin Medical University, 157, Baojian Street, Nangang District, Harbin, Heilongjiang, People's Republic of China aut Chunqing Lin Department of Epidemiology, Public Health College, Harbin Medical University, 157, Baojian Street, Nangang District, Harbin, Heilongjiang, People's Republic of China aut Fan Wang Department of Epidemiology, Public Health College, Harbin Medical University, 157, Baojian Street, Nangang District, Harbin, Heilongjiang, People's Republic of China aut Dandan Li Department of Epidemiology, Public Health College, Harbin Medical University, 157, Baojian Street, Nangang District, Harbin, Heilongjiang, People's Republic of China aut Dianjun Sun Center for Endemic Disease Control, Harbin Medical University, Harbin, Heilongjiang Province, People's Republic of China aut Tong Wang Center for Endemic Disease Control, Harbin Medical University, Harbin, Heilongjiang Province, People's Republic of China aut Da Pang Department of Breast Surgery, Third Affiliated Clinical Hospital of Harbin Medical University, 150, Haping Street, Nangang District, Harbin, Heilongjiang Province, People's Republic of China aut Yashuang Zhao Department of Epidemiology, Public Health College, Harbin Medical University, 157, Baojian Street, Nangang District, Harbin, Heilongjiang, People's Republic of China aut Cancer Causes & Control Springer Netherlands 22/10(2011-10-01), 1383-1396 0957-5243 22:10<1383 2011 22 10552 https://doi.org/10.1007/s10552-011-9811-y text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10552-011-9811-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Fulan Hu Department of Epidemiology, Public Health College, Harbin Medical University, 157, Baojian Street, Nangang District, Harbin, Heilongjiang, People's Republic of China aut NATIONALLICENCE 700 1- Changxing Jiang Center for Endemic Disease Control, Harbin Medical University, Harbin, Heilongjiang Province, People's Republic of China aut NATIONALLICENCE 700 1- Baina Wang Department of Epidemiology, Public Health College, Harbin Medical University, 157, Baojian Street, Nangang District, Harbin, Heilongjiang, People's Republic of China aut NATIONALLICENCE 700 1- Wencui Zhang Department of Epidemiology, Public Health College, Harbin Medical University, 157, Baojian Street, Nangang District, Harbin, Heilongjiang, People's Republic of China aut NATIONALLICENCE 700 1- Chunqing Lin Department of Epidemiology, Public Health College, Harbin Medical University, 157, Baojian Street, Nangang District, Harbin, Heilongjiang, People's Republic of China aut NATIONALLICENCE 700 1- Fan Wang Department of Epidemiology, Public Health College, Harbin Medical University, 157, Baojian Street, Nangang District, Harbin, Heilongjiang, People's Republic of China aut NATIONALLICENCE 700 1- Dandan Li Department of Epidemiology, Public Health College, Harbin Medical University, 157, Baojian Street, Nangang District, Harbin, Heilongjiang, People's Republic of China aut NATIONALLICENCE 700 1- Dianjun Sun Center for Endemic Disease Control, Harbin Medical University, Harbin, Heilongjiang Province, People's Republic of China aut NATIONALLICENCE 700 1- Tong Wang Center for Endemic Disease Control, Harbin Medical University, Harbin, Heilongjiang Province, People's Republic of China aut NATIONALLICENCE 700 1- Da Pang Department of Breast Surgery, Third Affiliated Clinical Hospital of Harbin Medical University, 150, Haping Street, Nangang District, Harbin, Heilongjiang Province, People's Republic of China aut NATIONALLICENCE 700 1- Yashuang Zhao Department of Epidemiology, Public Health College, Harbin Medical University, 157, Baojian Street, Nangang District, Harbin, Heilongjiang, People's Republic of China aut NATIONALLICENCE 773 0- Cancer Causes & Control Springer Netherlands 22/10(2011-10-01), 1383-1396 0957-5243 22:10<1383 2011 22 10552 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer