caa a22 4500 445315547 CHVBK 20180317142645.0 cr unu---uuuuu 170323e20111001xx s 000 0 eng 10.1007/s10552-011-9820-x doi (NATIONALLICENCE)springer-10.1007/s10552-011-9820-x The association between height and prostate cancer grade in the Early Stage Prostate Cancer Cohort Study [Elektronische Daten] [Wildon Farwell, Christopher Lourenco, Erika Holmberg, Robert Hall, Leonard D'Avolio, Elizabeth Lawler, J. Michael Gaziano] Objective: We examined the relationship between height and prostate cancer grade. Methods: The Early Stage Prostate Cancer Cohort Study is an observational cohort of 1,037 men diagnosed with early-stage prostate cancer, T0-3NxM0. High-grade prostate cancer was defined as a biopsy Gleason score≥7 (4+3). Logistic regression models were created to calculate odds ratios (OR) and 95% confidence intervals (CI) for the cross-sectional relationship between height and prostate cancer grade in the overall cohort and subpopulations. Results: We identified 939 participants with a biopsy Gleason score. High-grade prostate cancer was diagnosed in 138 participants. Overall, participants in the highest quartile of height were more than twice as likely to have a Gleason score≥7 (4+3) than participants in the lowest quartile of height, OR 2.14 (95% CI 1.11, 4.14), after multivariate adjustment. Participants in the highest quartile of height were more likely to be diagnosed with high-grade prostate cancer than participants in the lowest quartile of height among participants who were black, OR 8.00 (95% CI 1.99, 32.18), and participants who had diabetes mellitus, OR 5.09 (95% CI 1.30, 19.98). Conclusions: Height is associated with increased risk of high-grade prostate cancer overall and perhaps among certain subpopulations. Springer Science+Business Media B.V. (outside the USA), 2011 Prostatic neoplasms nationallicence Body height nationallicence Epidemiology nationallicence Farwell Wildon Massachusetts Veterans Epidemiology and Research Information Center, Veterans Affairs Medical Center, Boston, MA, USA aut Lourenco Christopher Massachusetts Veterans Epidemiology and Research Information Center, Veterans Affairs Medical Center, Boston, MA, USA aut Holmberg Erika Massachusetts Veterans Epidemiology and Research Information Center, Veterans Affairs Medical Center, Boston, MA, USA aut Hall Robert Massachusetts Veterans Epidemiology and Research Information Center, Veterans Affairs Medical Center, Boston, MA, USA aut D'Avolio Leonard Massachusetts Veterans Epidemiology and Research Information Center, Veterans Affairs Medical Center, Boston, MA, USA aut Lawler Elizabeth Massachusetts Veterans Epidemiology and Research Information Center, Veterans Affairs Medical Center, Boston, MA, USA aut Michael Gaziano J. Massachusetts Veterans Epidemiology and Research Information Center, Veterans Affairs Medical Center, Boston, MA, USA aut Cancer Causes & Control Springer Netherlands 22/10(2011-10-01), 1453-1459 0957-5243 22:10<1453 2011 22 10552 https://doi.org/10.1007/s10552-011-9820-x text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10552-011-9820-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Farwell Wildon Massachusetts Veterans Epidemiology and Research Information Center, Veterans Affairs Medical Center, Boston, MA, USA aut NATIONALLICENCE 700 1- Lourenco Christopher Massachusetts Veterans Epidemiology and Research Information Center, Veterans Affairs Medical Center, Boston, MA, USA aut NATIONALLICENCE 700 1- Holmberg Erika Massachusetts Veterans Epidemiology and Research Information Center, Veterans Affairs Medical Center, Boston, MA, USA aut NATIONALLICENCE 700 1- Hall Robert Massachusetts Veterans Epidemiology and Research Information Center, Veterans Affairs Medical Center, Boston, MA, USA aut NATIONALLICENCE 700 1- D'Avolio Leonard Massachusetts Veterans Epidemiology and Research Information Center, Veterans Affairs Medical Center, Boston, MA, USA aut NATIONALLICENCE 700 1- Lawler Elizabeth Massachusetts Veterans Epidemiology and Research Information Center, Veterans Affairs Medical Center, Boston, MA, USA aut NATIONALLICENCE 700 1- Michael Gaziano J. Massachusetts Veterans Epidemiology and Research Information Center, Veterans Affairs Medical Center, Boston, MA, USA aut NATIONALLICENCE 773 0- Cancer Causes & Control Springer Netherlands 22/10(2011-10-01), 1453-1459 0957-5243 22:10<1453 2011 22 10552 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer