caa a22 4500 445315555 CHVBK 20180317142645.0 cr unu---uuuuu 170323e20111001xx s 000 0 eng 10.1007/s10552-011-9813-9 doi (NATIONALLICENCE)springer-10.1007/s10552-011-9813-9 Dietary fiber and grain consumption in relation to head and neck cancer in the NIH-AARP Diet and Health Study [Elektronische Daten] [Tram Lam, Amanda Cross, Neal Freedman, Yikyung Park, Albert Hollenbeck, Arthur Schatzkin, Christian Abnet] Background: Dietary fiber and grain consumption may reduce the risk of head and neck cancer; however, the epidemiological evidence is limited. We investigated this relationship in the National Institutes of Health (NIH)-AARP Diet and Health Study. Methods: Cox proportional hazards models were used to calculate multivariable hazard ratios (HR) and 95% confidence intervals (CI) to investigate dietary fiber and grain intake in relation to head and neck cancer. Results: During approximately 11years of follow-up, 1,867 (401 women/1,466 men) cases of head and neck cancer were diagnosed. Our data indicated that the relationship between fiber and grain intake and head and neck cancer is modified by sex (p-interactions<0.001 and 0.001, respectively). Women with higher intake of total fiber and total grains had a lower risk of head and neck cancer (HR10g/day=0.77, 95% CI=0.64-0.93; HRserving/1,000kcal=0.89, 95% CI=0.80-0.99, respectively); this inverse relation was consistent across subtypes of fiber and grains. Conversely in men, the inverse associations were weaker and nonsignificant. Conclusions: In the largest prospective cohort study to investigate this relation to date, intake of total fiber and grain foods was inversely associated with head and neck cancer incidence among women, but not among men. Springer Science+Business Media B.V. (outside the USA), 2011 Diet nationallicence Fiber nationallicence Grains nationallicence Head and neck cancer nationallicence Prospective study nationallicence Lam Tram Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics (DCEG), National Cancer Institute (NCI), National Institutes of Health (NIH), 20852, Rockville, MD, USA aut Cross Amanda Nutritional Epidemiology Branch, DCEG, NCI, NIH, Rockville, MD, USA aut Freedman Neal Nutritional Epidemiology Branch, DCEG, NCI, NIH, Rockville, MD, USA aut Park Yikyung Nutritional Epidemiology Branch, DCEG, NCI, NIH, Rockville, MD, USA aut Hollenbeck Albert AARP, Washington, DC, USA aut Schatzkin Arthur Nutritional Epidemiology Branch, DCEG, NCI, NIH, Rockville, MD, USA aut Abnet Christian Nutritional Epidemiology Branch, DCEG, NCI, NIH, Rockville, MD, USA aut Cancer Causes & Control Springer Netherlands 22/10(2011-10-01), 1405-1414 0957-5243 22:10<1405 2011 22 10552 https://doi.org/10.1007/s10552-011-9813-9 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10552-011-9813-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Lam Tram Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics (DCEG), National Cancer Institute (NCI), National Institutes of Health (NIH), 20852, Rockville, MD, USA aut NATIONALLICENCE 700 1- Cross Amanda Nutritional Epidemiology Branch, DCEG, NCI, NIH, Rockville, MD, USA aut NATIONALLICENCE 700 1- Freedman Neal Nutritional Epidemiology Branch, DCEG, NCI, NIH, Rockville, MD, USA aut NATIONALLICENCE 700 1- Park Yikyung Nutritional Epidemiology Branch, DCEG, NCI, NIH, Rockville, MD, USA aut NATIONALLICENCE 700 1- Hollenbeck Albert AARP, Washington, DC, USA aut NATIONALLICENCE 700 1- Schatzkin Arthur Nutritional Epidemiology Branch, DCEG, NCI, NIH, Rockville, MD, USA aut NATIONALLICENCE 700 1- Abnet Christian Nutritional Epidemiology Branch, DCEG, NCI, NIH, Rockville, MD, USA aut NATIONALLICENCE 773 0- Cancer Causes & Control Springer Netherlands 22/10(2011-10-01), 1405-1414 0957-5243 22:10<1405 2011 22 10552 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer