caa a22 4500 445315563 CHVBK 20180317142645.0 cr unu---uuuuu 170323e20111001xx s 000 0 eng 10.1007/s10552-011-9827-3 doi (NATIONALLICENCE)springer-10.1007/s10552-011-9827-3 The determinants of serum vitamin D levels in participants in a melanoma case-control study living in a temperate climate [Elektronische Daten] [John Davies, Yu-Mei Chang, Helen Snowden, May Chan, Susan Leake, Birute Karpavicius, Sue Haynes, Kairen Kukalizch, Juliette Randerson-Moor, Faye Elliott, Julian Barth, Peter Kanetsky, Mark Harland, D. Bishop, Jennifer Barrett, Julia Newton-Bishop] Background: We report the determinants of serum levels of vitamin D in a UK melanoma case-control study benefitting from detailed exposure and genotyping data. Methods: Sun exposure, supplemental vitamin D, and SNPs reported to be associated with serum levels were assessed as predictors of a single serum 25-hydroxyvitamin D3 measurement adjusted for season, age, sex, and body mass index. Results: Adjusted analyses showed that vitamin D levels were sub-optimal especially in the sun-sensitive individuals (−2.61nmol/L, p=0.03) and for inheritance of a genetic variant in the GC gene coding for the vitamin D-binding protein (−5.79 for heterozygotes versus wild type, p=<0.0001). Higher levels were associated with sun exposure at the weekend in summer (+4.71nmol/L per tertile, p=<0.0001), and on hot holidays (+4.17nmol/L per tertile, p=<0.0001). In smoothed scatter plots, vitamin D levels of 60nmol/L in the non-sun-sensitive individuals were achieved after an average 6h/day summer weekend sun exposure but not in the sun-sensitive individuals. Users of supplements had levels on average 11.0nmol/L higher, p=<0.0001, and achieved optimal levels irrespective of sun exposure. Conclusions: Sun exposure was associated with increased vitamin D levels, but levels more than 60nmol/L were reached on average only in individuals reporting lengthy exposure (≥12h/weekend). The sun-sensitive individuals did not achieve optimal levels without supplementation, which therefore should be considered for the majority of populations living in a temperate climate and melanoma patients in particular. Inherited variation in genes such as GC is a strong factor, and carriers of variant alleles may therefore require higher levels of supplementation. The Author(s), 2011 Vitamin D nationallicence Sun exposure nationallicence Vitamin D-binding protein nationallicence NADSYN1 nationallicence DHCR7 nationallicence GC nationallicence Sun sensitivity nationallicence Supplementation nationallicence Insufficiency nationallicence CYP2R1 nationallicence OR : Odds ratio nationallicence CI : Confidence intervals nationallicence SNP : Single-nucleotide polymorphism nationallicence Davies John Section of Epidemiology and Biostatistics, Leeds Institute of Molecular Medicine, University of Leeds, Cancer Genetics Building, St James's Hospital, Beckett Street, LS9 7TF, Leeds, UK aut Chang Yu-Mei Section of Epidemiology and Biostatistics, Leeds Institute of Molecular Medicine, University of Leeds, Cancer Genetics Building, St James's Hospital, Beckett Street, LS9 7TF, Leeds, UK aut Snowden Helen Section of Epidemiology and Biostatistics, Leeds Institute of Molecular Medicine, University of Leeds, Cancer Genetics Building, St James's Hospital, Beckett Street, LS9 7TF, Leeds, UK aut Chan May Section of Epidemiology and Biostatistics, Leeds Institute of Molecular Medicine, University of Leeds, Cancer Genetics Building, St James's Hospital, Beckett Street, LS9 7TF, Leeds, UK aut Leake Susan Section of Epidemiology and Biostatistics, Leeds Institute of Molecular Medicine, University of Leeds, Cancer Genetics Building, St James's Hospital, Beckett Street, LS9 7TF, Leeds, UK aut Karpavicius Birute Section of Epidemiology and Biostatistics, Leeds Institute of Molecular Medicine, University of Leeds, Cancer Genetics Building, St James's Hospital, Beckett Street, LS9 7TF, Leeds, UK aut Haynes Sue Section of Epidemiology and Biostatistics, Leeds Institute of Molecular Medicine, University of Leeds, Cancer Genetics Building, St James's Hospital, Beckett Street, LS9 7TF, Leeds, UK aut Kukalizch Kairen Section of Epidemiology and Biostatistics, Leeds Institute of Molecular Medicine, University of Leeds, Cancer Genetics Building, St James's Hospital, Beckett Street, LS9 7TF, Leeds, UK aut Randerson-Moor Juliette Section of Epidemiology and Biostatistics, Leeds Institute of Molecular Medicine, University of Leeds, Cancer Genetics Building, St James's Hospital, Beckett Street, LS9 7TF, Leeds, UK aut Elliott Faye Section of Epidemiology and Biostatistics, Leeds Institute of Molecular Medicine, University of Leeds, Cancer Genetics Building, St James's Hospital, Beckett Street, LS9 7TF, Leeds, UK aut Barth Julian Department of Clinical Biochemistry, Leeds Teaching Hospitals Trust, Leeds, UK aut Kanetsky Peter Department of Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, PA, USA aut Harland Mark Section of Epidemiology and Biostatistics, Leeds Institute of Molecular Medicine, University of Leeds, Cancer Genetics Building, St James's Hospital, Beckett Street, LS9 7TF, Leeds, UK aut Bishop D. Section of Epidemiology and Biostatistics, Leeds Institute of Molecular Medicine, University of Leeds, Cancer Genetics Building, St James's Hospital, Beckett Street, LS9 7TF, Leeds, UK aut Barrett Jennifer Section of Epidemiology and Biostatistics, Leeds Institute of Molecular Medicine, University of Leeds, Cancer Genetics Building, St James's Hospital, Beckett Street, LS9 7TF, Leeds, UK aut Newton-Bishop Julia Section of Epidemiology and Biostatistics, Leeds Institute of Molecular Medicine, University of Leeds, Cancer Genetics Building, St James's Hospital, Beckett Street, LS9 7TF, Leeds, UK aut Cancer Causes & Control Springer Netherlands 22/10(2011-10-01), 1471-1482 0957-5243 22:10<1471 2011 22 10552 https://doi.org/10.1007/s10552-011-9827-3 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10552-011-9827-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Davies John Section of Epidemiology and Biostatistics, Leeds Institute of Molecular Medicine, University of Leeds, Cancer Genetics Building, St James's Hospital, Beckett Street, LS9 7TF, Leeds, UK aut NATIONALLICENCE 700 1- Chang Yu-Mei Section of Epidemiology and Biostatistics, Leeds Institute of Molecular Medicine, University of Leeds, Cancer Genetics Building, St James's Hospital, Beckett Street, LS9 7TF, Leeds, UK aut NATIONALLICENCE 700 1- Snowden Helen Section of Epidemiology and Biostatistics, Leeds Institute of Molecular Medicine, University of Leeds, Cancer Genetics Building, St James's Hospital, Beckett Street, LS9 7TF, Leeds, UK aut NATIONALLICENCE 700 1- Chan May Section of Epidemiology and Biostatistics, Leeds Institute of Molecular Medicine, University of Leeds, Cancer Genetics Building, St James's Hospital, Beckett Street, LS9 7TF, Leeds, UK aut NATIONALLICENCE 700 1- Leake Susan Section of Epidemiology and Biostatistics, Leeds Institute of Molecular Medicine, University of Leeds, Cancer Genetics Building, St James's Hospital, Beckett Street, LS9 7TF, Leeds, UK aut NATIONALLICENCE 700 1- Karpavicius Birute Section of Epidemiology and Biostatistics, Leeds Institute of Molecular Medicine, University of Leeds, Cancer Genetics Building, St James's Hospital, Beckett Street, LS9 7TF, Leeds, UK aut NATIONALLICENCE 700 1- Haynes Sue Section of Epidemiology and Biostatistics, Leeds Institute of Molecular Medicine, University of Leeds, Cancer Genetics Building, St James's Hospital, Beckett Street, LS9 7TF, Leeds, UK aut NATIONALLICENCE 700 1- Kukalizch Kairen Section of Epidemiology and Biostatistics, Leeds Institute of Molecular Medicine, University of Leeds, Cancer Genetics Building, St James's Hospital, Beckett Street, LS9 7TF, Leeds, UK aut NATIONALLICENCE 700 1- Randerson-Moor Juliette Section of Epidemiology and Biostatistics, Leeds Institute of Molecular Medicine, University of Leeds, Cancer Genetics Building, St James's Hospital, Beckett Street, LS9 7TF, Leeds, UK aut NATIONALLICENCE 700 1- Elliott Faye Section of Epidemiology and Biostatistics, Leeds Institute of Molecular Medicine, University of Leeds, Cancer Genetics Building, St James's Hospital, Beckett Street, LS9 7TF, Leeds, UK aut NATIONALLICENCE 700 1- Barth Julian Department of Clinical Biochemistry, Leeds Teaching Hospitals Trust, Leeds, UK aut NATIONALLICENCE 700 1- Kanetsky Peter Department of Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, PA, USA aut NATIONALLICENCE 700 1- Harland Mark Section of Epidemiology and Biostatistics, Leeds Institute of Molecular Medicine, University of Leeds, Cancer Genetics Building, St James's Hospital, Beckett Street, LS9 7TF, Leeds, UK aut NATIONALLICENCE 700 1- Bishop D. Section of Epidemiology and Biostatistics, Leeds Institute of Molecular Medicine, University of Leeds, Cancer Genetics Building, St James's Hospital, Beckett Street, LS9 7TF, Leeds, UK aut NATIONALLICENCE 700 1- Barrett Jennifer Section of Epidemiology and Biostatistics, Leeds Institute of Molecular Medicine, University of Leeds, Cancer Genetics Building, St James's Hospital, Beckett Street, LS9 7TF, Leeds, UK aut NATIONALLICENCE 700 1- Newton-Bishop Julia Section of Epidemiology and Biostatistics, Leeds Institute of Molecular Medicine, University of Leeds, Cancer Genetics Building, St James's Hospital, Beckett Street, LS9 7TF, Leeds, UK aut NATIONALLICENCE 773 0- Cancer Causes & Control Springer Netherlands 22/10(2011-10-01), 1471-1482 0957-5243 22:10<1471 2011 22 10552 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer