caa a22 4500 44531558X CHVBK 20180317142645.0 cr unu---uuuuu 170323e20110401xx s 000 0 eng 10.1007/s10552-011-9735-6 doi (NATIONALLICENCE)springer-10.1007/s10552-011-9735-6 Cigarette smoking shortens the survival of patients with low-risk myelodysplastic syndromes [Elektronische Daten] [Xiaomei Ma, Rong Wang, Naomi Galili, Susan Mayne, Sa Wang, Herbert Yu, Azra Raza] Myelodysplastic syndromes (MDS) are a group of hematological malignancies with poor survival. Although previous studies have identified the prognostic role of multiple demographic and clinical characteristics, the potential role of lifestyle factors has not been evaluated. In this study, we conducted an extensive assessment of the predictors of MDS survival, with a special focus on lifestyle factors. A total of 616 patients (median survival=4.1years) were included in the analysis, and multivariate Cox proportional hazard models were utilized to estimate hazard ratios. Compared with non-smokers, MDS patients who smoked at the initial clinical encounter had a significantly increased risk of death [hazard ratio (HR)=1.46, 95% confidence intervals (CI): 1.07-2.00]. The elevated risk was restricted to men (HR=1.76, 95% CI: 1.21-2.56) and not observed among women (HR=0.98, 95% CI: 0.51-1.85). When patients were stratified by the IPSS categorization, a near three fold increased risk of death was associated with smoking among patients with low-risk MDS (HR=2.83, 95% CI: 1.48-5.39), whereas smoking did not appear to influence the survival of patients with intermediate- or high-risk MDS. This study was the first to identify smoking as a significant and independent predictor of MDS survival, particularly among low-risk patients. Springer Science+Business Media B.V., 2011 Myelodysplastic syndromes nationallicence Survival nationallicence Smoking nationallicence Ma Xiaomei Department of Epidemiology and Public Health, Yale University School of Medicine, 60 College St, Box 208034, 06520-8034, New Haven, CT, USA aut Wang Rong Department of Epidemiology and Public Health, Yale University School of Medicine, 60 College St, Box 208034, 06520-8034, New Haven, CT, USA aut Galili Naomi Columbia University Medical Center, New York, NY, USA aut Mayne Susan Department of Epidemiology and Public Health, Yale University School of Medicine, 60 College St, Box 208034, 06520-8034, New Haven, CT, USA aut Wang Sa M.D. Anderson Cancer Center, University of Texas Medical Center, Houston, TX, USA aut Yu Herbert Department of Epidemiology and Public Health, Yale University School of Medicine, 60 College St, Box 208034, 06520-8034, New Haven, CT, USA aut Raza Azra Columbia University Medical Center, New York, NY, USA aut Cancer Causes & Control Springer Netherlands 22/4(2011-04-01), 623-629 0957-5243 22:4<623 2011 22 10552 https://doi.org/10.1007/s10552-011-9735-6 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10552-011-9735-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ma Xiaomei Department of Epidemiology and Public Health, Yale University School of Medicine, 60 College St, Box 208034, 06520-8034, New Haven, CT, USA aut NATIONALLICENCE 700 1- Wang Rong Department of Epidemiology and Public Health, Yale University School of Medicine, 60 College St, Box 208034, 06520-8034, New Haven, CT, USA aut NATIONALLICENCE 700 1- Galili Naomi Columbia University Medical Center, New York, NY, USA aut NATIONALLICENCE 700 1- Mayne Susan Department of Epidemiology and Public Health, Yale University School of Medicine, 60 College St, Box 208034, 06520-8034, New Haven, CT, USA aut NATIONALLICENCE 700 1- Wang Sa M.D. Anderson Cancer Center, University of Texas Medical Center, Houston, TX, USA aut NATIONALLICENCE 700 1- Yu Herbert Department of Epidemiology and Public Health, Yale University School of Medicine, 60 College St, Box 208034, 06520-8034, New Haven, CT, USA aut NATIONALLICENCE 700 1- Raza Azra Columbia University Medical Center, New York, NY, USA aut NATIONALLICENCE 773 0- Cancer Causes & Control Springer Netherlands 22/4(2011-04-01), 623-629 0957-5243 22:4<623 2011 22 10552 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer