caa a22 4500 445315598 CHVBK 20180317142645.0 cr unu---uuuuu 170323e20110401xx s 000 0 eng 10.1007/s10552-011-9734-7 doi (NATIONALLICENCE)springer-10.1007/s10552-011-9734-7 Birth characteristics and female sex hormone concentrations during adolescence: results from the Dietary Intervention Study in Children [Elektronische Daten] [Elizabeth Ruder, Terryl Hartman, Michael Rovine, Joanne Dorgan] Background: Birth characteristics and adult hormone concentrations influence breast cancer risk, but little is known about the influence of birth characteristics on hormone concentrations, particularly during adolescence. Methods: We evaluated the association of birth characteristics (birth weight, birth length, and gestational age) with serum sex hormone concentrations during late childhood and adolescence in 278 female participants of the Dietary Intervention Study in Children. Repeated measures analysis of variance models were used to assess the relationships of birth characteristics and serum estrogens and androgens at five different time points over a mean period of 7years. Results: In analyses that did not take into account time from blood draw until menarche, birth weight was inversely associated with pre-menarche concentrations of estradiol, estrone sulfate, androstenedione, testosterone, and dehydroepiandrosterone sulfate (DHEAS). In the post-menarche analyses, birth weight was not significantly associated with concentration of any of the hormones under investigation. Birth length and gestational age were not associated with hormone concentrations before or after menarche. Conclusion: Birth weight is inversely associated with sex hormone concentrations before menarche in the model unadjusted for time from blood draw until menarche. Impact: The in utero environment has long-term influences on the hormonal milieu, which could potentially contribute to breast cancer risk. Springer Science+Business Media B.V.(outside the USA), 2011 Birth weight nationallicence Sex steroid hormones nationallicence Breast cancer risk factors nationallicence Adolescence nationallicence Puberty nationallicence Ruder Elizabeth Cancer Prevention Fellowship Program, Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Boulevard, Suite 320, MSC 7236, 20892, Bethesda, MD, USA aut Hartman Terryl Department of Nutritional Sciences, Pennsylvania State University, 104 Chandlee, 16802, University Park, PA, USA aut Rovine Michael Department of Human Development and Family Studies, Pennsylvania State University, 119-C Henderson Building, 16802, University Park, PA, USA aut Dorgan Joanne Fox Chase Cancer Center, 333 Cottman Avenue, 19111, Philadelphia, PA, USA aut Cancer Causes & Control Springer Netherlands 22/4(2011-04-01), 611-621 0957-5243 22:4<611 2011 22 10552 https://doi.org/10.1007/s10552-011-9734-7 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10552-011-9734-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ruder Elizabeth Cancer Prevention Fellowship Program, Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Boulevard, Suite 320, MSC 7236, 20892, Bethesda, MD, USA aut NATIONALLICENCE 700 1- Hartman Terryl Department of Nutritional Sciences, Pennsylvania State University, 104 Chandlee, 16802, University Park, PA, USA aut NATIONALLICENCE 700 1- Rovine Michael Department of Human Development and Family Studies, Pennsylvania State University, 119-C Henderson Building, 16802, University Park, PA, USA aut NATIONALLICENCE 700 1- Dorgan Joanne Fox Chase Cancer Center, 333 Cottman Avenue, 19111, Philadelphia, PA, USA aut NATIONALLICENCE 773 0- Cancer Causes & Control Springer Netherlands 22/4(2011-04-01), 611-621 0957-5243 22:4<611 2011 22 10552 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer