caa a22 4500 445315652 CHVBK 20180317142646.0 cr unu---uuuuu 170323e20110401xx s 000 0 eng 10.1007/s10552-011-9726-7 doi (NATIONALLICENCE)springer-10.1007/s10552-011-9726-7 Variation in folate pathway genes and distal colorectal adenoma risk: a sigmoidoscopy-based case-control study [Elektronische Daten] [A. Levine, Won Lee, Jane Figueiredo, David Conti, David Vandenberg, Brian Davis, Christopher Edlund, Susanne Henning, David Heber, Mariana Stern, Robert Haile] Background: Folate-associated one-carbon metabolism (FOCM) is an important pathway in colorectal neoplasia risk but data on genetic variation in this pathway are largely limited to studies of single SNPs in selected genes. Methods: We used a comprehensive tagSNP approach to study the association between genetic variation in 11 genes in the FOCM pathway and risk of incident distal colorectal adenomas in a sigmoidoscopy-based case-control study. We included 655 cases (one or more adenomas) and 695 controls (no adenomas) recruited from one of two Kaiser Permanente clinics between 1991 and 1995. We assessed a total of 159 tagSNPs selected using Haploview Tagger as well as selected non-synonymous SNPs. We used unconditional logistic regression to model the association between SNPs and risk of distal adenomas, assuming a log-additive model. Results: Five SNPs in the SLC19A1 (RFC1) gene: rs1051266 (G80A), rs283895, rs2236484, rs12482346, and rs2838958 were associated with adenoma risk after correction for multiple testing (all corrected p values ≤0.043). The non-synonymous SLC19A1 SNP G80A interacted significantly with the MTHFR C677T genotype (interaction p value=0.018). Conclusion: Our data suggest that genetic variation in SLC19A1 may modify the risk of distal colorectal adenoma. The Author(s), 2011 Folate nationallicence MTHFR nationallicence SLC19A1 nationallicence TagSNP nationallicence Folate nationallicence Colorectal adenoma nationallicence Levine A. Department of Preventive Medicine, Genetic Epidemiology, University of Southern California Keck School of Medicine, NRT 1450 Biggy Street Room 1509A, 90033, Los Angeles, CA, USA aut Lee Won Department of Preventive Medicine, Genetic Epidemiology, University of Southern California Keck School of Medicine, NRT 1450 Biggy Street Room 1509A, 90033, Los Angeles, CA, USA aut Figueiredo Jane Department of Preventive Medicine, Genetic Epidemiology, University of Southern California Keck School of Medicine, NRT 1450 Biggy Street Room 1509A, 90033, Los Angeles, CA, USA aut Conti David Department of Preventive Medicine, Genetic Epidemiology, University of Southern California Keck School of Medicine, NRT 1450 Biggy Street Room 1509A, 90033, Los Angeles, CA, USA aut Vandenberg David Department of Preventive Medicine, Genetic Epidemiology, University of Southern California Keck School of Medicine, NRT 1450 Biggy Street Room 1509A, 90033, Los Angeles, CA, USA aut Davis Brian Department of Preventive Medicine, Genetic Epidemiology, University of Southern California Keck School of Medicine, NRT 1450 Biggy Street Room 1509A, 90033, Los Angeles, CA, USA aut Edlund Christopher Department of Preventive Medicine, Genetic Epidemiology, University of Southern California Keck School of Medicine, NRT 1450 Biggy Street Room 1509A, 90033, Los Angeles, CA, USA aut Henning Susanne Center for Human Nutrition, David Geffen School of Medicine, University of California, 90095, Los Angeles, CA, USA aut Heber David Center for Human Nutrition, David Geffen School of Medicine, University of California, 90095, Los Angeles, CA, USA aut Stern Mariana Department of Preventive Medicine, Genetic Epidemiology, University of Southern California Keck School of Medicine, NRT 1450 Biggy Street Room 1509A, 90033, Los Angeles, CA, USA aut Haile Robert Department of Preventive Medicine, Genetic Epidemiology, University of Southern California Keck School of Medicine, NRT 1450 Biggy Street Room 1509A, 90033, Los Angeles, CA, USA aut Cancer Causes & Control Springer Netherlands 22/4(2011-04-01), 541-552 0957-5243 22:4<541 2011 22 10552 https://doi.org/10.1007/s10552-011-9726-7 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10552-011-9726-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Levine A. Department of Preventive Medicine, Genetic Epidemiology, University of Southern California Keck School of Medicine, NRT 1450 Biggy Street Room 1509A, 90033, Los Angeles, CA, USA aut NATIONALLICENCE 700 1- Lee Won Department of Preventive Medicine, Genetic Epidemiology, University of Southern California Keck School of Medicine, NRT 1450 Biggy Street Room 1509A, 90033, Los Angeles, CA, USA aut NATIONALLICENCE 700 1- Figueiredo Jane Department of Preventive Medicine, Genetic Epidemiology, University of Southern California Keck School of Medicine, NRT 1450 Biggy Street Room 1509A, 90033, Los Angeles, CA, USA aut NATIONALLICENCE 700 1- Conti David Department of Preventive Medicine, Genetic Epidemiology, University of Southern California Keck School of Medicine, NRT 1450 Biggy Street Room 1509A, 90033, Los Angeles, CA, USA aut NATIONALLICENCE 700 1- Vandenberg David Department of Preventive Medicine, Genetic Epidemiology, University of Southern California Keck School of Medicine, NRT 1450 Biggy Street Room 1509A, 90033, Los Angeles, CA, USA aut NATIONALLICENCE 700 1- Davis Brian Department of Preventive Medicine, Genetic Epidemiology, University of Southern California Keck School of Medicine, NRT 1450 Biggy Street Room 1509A, 90033, Los Angeles, CA, USA aut NATIONALLICENCE 700 1- Edlund Christopher Department of Preventive Medicine, Genetic Epidemiology, University of Southern California Keck School of Medicine, NRT 1450 Biggy Street Room 1509A, 90033, Los Angeles, CA, USA aut NATIONALLICENCE 700 1- Henning Susanne Center for Human Nutrition, David Geffen School of Medicine, University of California, 90095, Los Angeles, CA, USA aut NATIONALLICENCE 700 1- Heber David Center for Human Nutrition, David Geffen School of Medicine, University of California, 90095, Los Angeles, CA, USA aut NATIONALLICENCE 700 1- Stern Mariana Department of Preventive Medicine, Genetic Epidemiology, University of Southern California Keck School of Medicine, NRT 1450 Biggy Street Room 1509A, 90033, Los Angeles, CA, USA aut NATIONALLICENCE 700 1- Haile Robert Department of Preventive Medicine, Genetic Epidemiology, University of Southern California Keck School of Medicine, NRT 1450 Biggy Street Room 1509A, 90033, Los Angeles, CA, USA aut NATIONALLICENCE 773 0- Cancer Causes & Control Springer Netherlands 22/4(2011-04-01), 541-552 0957-5243 22:4<541 2011 22 10552 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer