caa a22 4500 445315679 CHVBK 20180317142646.0 cr unu---uuuuu 170323e20110401xx s 000 0 eng 10.1007/s10552-011-9730-y doi (NATIONALLICENCE)springer-10.1007/s10552-011-9730-y Weight loss and postmenopausal breast cancer in a prospective cohort of overweight and obese US women [Elektronische Daten] [Lauren Teras, Michael Goodman, Alpa Patel, W. Ryan Diver, W. Dana Flanders, Heather Feigelson] Overweight and obesity are associated with increased postmenopausal breast cancer risk; however, it is unclear whether losing excess weight will lower risk. Therefore, we examined the relationship between weight loss and postmenopausal breast cancer among 13,055 overweight and obese, cancer-free women who enrolled in the Cancer Prevention Study-II (CPS-II) Nutrition Cohort in 1992. During the 15year follow-up, 816 postmenopausal breast cancer cases were diagnosed. Self-reported weight was collected before diagnosis at baseline and 10years prior to baseline. The median weight loss was 11lbs, but only 58% of the women maintained this weight loss through the first 5year follow-up interval (1992-1997). Using both restricted cubic splines and multivariate Cox proportional hazards modeling, we observed no association between weight loss and postmenopausal breast cancer. The hazard ratio for 30+ pounds of weight loss compared to stable weight was 0.95 (95%: CI 0.47-1.95). An inverse association was, however, suggested among women who maintained ten or more pounds of weight loss through the next interval. There was no evidence of effect modification by postmenopausal hormone use, initial BMI, or other factors examined. In summary, weight loss was not associated with postmenopausal breast cancer in this study. Future studies should focus on sustained weight loss and whether the timing of weight loss is important. Springer Science+Business Media B.V., 2011 Breast cancer nationallicence Obesity nationallicence Weight loss nationallicence Cohort nationallicence Teras Lauren Epidemiology Research Program, American Cancer Society, National Home Office, 250 Williams St. NW, 30303, Atlanta, GA, USA aut Goodman Michael Emory University, Atlanta, GA, USA aut Patel Alpa Epidemiology Research Program, American Cancer Society, National Home Office, 250 Williams St. NW, 30303, Atlanta, GA, USA aut Ryan Diver W. Epidemiology Research Program, American Cancer Society, National Home Office, 250 Williams St. NW, 30303, Atlanta, GA, USA aut Dana Flanders W. Emory University, Atlanta, GA, USA aut Feigelson Heather Kaiser Permanente, Denver, CO, USA aut Cancer Causes & Control Springer Netherlands 22/4(2011-04-01), 573-579 0957-5243 22:4<573 2011 22 10552 https://doi.org/10.1007/s10552-011-9730-y text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10552-011-9730-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Teras Lauren Epidemiology Research Program, American Cancer Society, National Home Office, 250 Williams St. NW, 30303, Atlanta, GA, USA aut NATIONALLICENCE 700 1- Goodman Michael Emory University, Atlanta, GA, USA aut NATIONALLICENCE 700 1- Patel Alpa Epidemiology Research Program, American Cancer Society, National Home Office, 250 Williams St. NW, 30303, Atlanta, GA, USA aut NATIONALLICENCE 700 1- Ryan Diver W. Epidemiology Research Program, American Cancer Society, National Home Office, 250 Williams St. NW, 30303, Atlanta, GA, USA aut NATIONALLICENCE 700 1- Dana Flanders W. Emory University, Atlanta, GA, USA aut NATIONALLICENCE 700 1- Feigelson Heather Kaiser Permanente, Denver, CO, USA aut NATIONALLICENCE 773 0- Cancer Causes & Control Springer Netherlands 22/4(2011-04-01), 573-579 0957-5243 22:4<573 2011 22 10552 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer