caa a22 4500 445315849 CHVBK 20180317142646.0 cr unu---uuuuu 170323e20110801xx s 000 0 eng 10.1007/s10552-011-9798-4 doi (NATIONALLICENCE)springer-10.1007/s10552-011-9798-4 Maternal exposure to household chemicals and risk of infant leukemia: a report from the Children's Oncology Group [Elektronische Daten] [Megan Slater, Amy Linabery, Logan Spector, Kimberly Johnson, Joanne Hilden, Nyla Heerema, Leslie Robison, Julie Ross] Objective: Utilizing data from the largest study to date, we examined associations between maternal preconception/prenatal exposure to household chemicals and infant acute leukemia. Methods: We present data from a Children's Oncology Group case-control study of 443 infants (<1year of age) diagnosed with acute leukemia [including acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML)] between 1996 and 2006 and 324 population controls. Mothers recalled household chemical use 1month before and throughout pregnancy. We used unconditional logistic regression adjusted for birth year, maternal age, and race/ethnicity to calculate odds ratios (ORs) and 95% confidence intervals (CIs). Results: We did not find evidence for an association between infant leukemia and eight of nine chemical categories. However, exposure to petroleum products during pregnancy was associated with AML (OR=2.54; 95% CI:1.40-4.62) and leukemia without mixed lineage leukemia (MLL) gene rearrangements ("MLL−”) (OR=2.69; 95% CI: 1.47-4.93). No associations were observed for exposure in the month before pregnancy. Conclusions: Gestational exposure to petroleum products was associated with infant leukemia, particularly AML, and MLL− cases. Benzene is implicated as a potential carcinogen within this exposure category, but a clear biological mechanism has yet to be elucidated. Springer Science+Business Media B.V., 2011 Epidemiology nationallicence Infants nationallicence Leukemia nationallicence Chemical nationallicence Prenatal nationallicence Slater Megan Division of Pediatric Epidemiology and Clinical Research, Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA aut Linabery Amy Division of Pediatric Epidemiology and Clinical Research, Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA aut Spector Logan Division of Pediatric Epidemiology and Clinical Research, Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA aut Johnson Kimberly Division of Pediatric Epidemiology and Clinical Research, Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA aut Hilden Joanne Peyton Manning Children's Hospital at St. Vincent, Indianapolis, IN, USA aut Heerema Nyla Department of Pathology, The Ohio State University, Columbus, OH, USA aut Robison Leslie Department of Epidemiology and Cancer Control, St. Jude Children's Research Hospital, Memphis, TN, USA aut Ross Julie Division of Pediatric Epidemiology and Clinical Research, Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA aut Cancer Causes & Control Springer Netherlands 22/8(2011-08-01), 1197-1204 0957-5243 22:8<1197 2011 22 10552 https://doi.org/10.1007/s10552-011-9798-4 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10552-011-9798-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Slater Megan Division of Pediatric Epidemiology and Clinical Research, Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA aut NATIONALLICENCE 700 1- Linabery Amy Division of Pediatric Epidemiology and Clinical Research, Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA aut NATIONALLICENCE 700 1- Spector Logan Division of Pediatric Epidemiology and Clinical Research, Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA aut NATIONALLICENCE 700 1- Johnson Kimberly Division of Pediatric Epidemiology and Clinical Research, Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA aut NATIONALLICENCE 700 1- Hilden Joanne Peyton Manning Children's Hospital at St. Vincent, Indianapolis, IN, USA aut NATIONALLICENCE 700 1- Heerema Nyla Department of Pathology, The Ohio State University, Columbus, OH, USA aut NATIONALLICENCE 700 1- Robison Leslie Department of Epidemiology and Cancer Control, St. Jude Children's Research Hospital, Memphis, TN, USA aut NATIONALLICENCE 700 1- Ross Julie Division of Pediatric Epidemiology and Clinical Research, Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA aut NATIONALLICENCE 773 0- Cancer Causes & Control Springer Netherlands 22/8(2011-08-01), 1197-1204 0957-5243 22:8<1197 2011 22 10552 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer