caa a22 4500 445315865 CHVBK 20180317142646.0 cr unu---uuuuu 170323e20110501xx s 000 0 eng 10.1007/s10552-011-9745-4 doi (NATIONALLICENCE)springer-10.1007/s10552-011-9745-4 Genomics of the NF-κB signaling pathway: hypothesized role in ovarian cancer [Elektronische Daten] [Kristin White, David Rider, Kimberly Kalli, Keith Knutson, Gail Jarvik, Ellen Goode] Objective: We sought to review evidence linking nuclear factor-kappa B (NF-κB) to ovarian cancer and to identify genetic variants involved in NF-κB signaling. Methods: PubMed was reviewed to inform on ovarian cancer biology and NF-κB signaling and to identify key genes. Public linkage disequilibrium (LD) data were analyzed to identify informative inherited variants (tagSNPs) using ldSelect. Results: We identified 319 key NF-κB genes including five NF-κB subunits, 167 activating genes, and 55 inhibiting genes. We found that the 1000 Genomes Project was the most informative LD source for most genes (92.8%), and we identified 13,027 LD bins (r 2≥0.9, minor allele frequency≥0.05) and 1,018 putative-functional variants worthy of investigation. We also report that reliance on a commonly used genome-wide SNP array and genotype imputation with HapMap Phase II data provides data on only 74% of the common inherited NF-κB SNPs of interest. Conclusions: Compelling evidence suggests that NF-κB plays a critical role in ovarian cancer, yet inherited variation in these genes has not been thoroughly assessed in relation to disease risk or outcome. We present a collection of variants in key genes and suggest creation of a custom genotyping array as an optimal approach. Springer Science+Business Media B.V., 2011 Association studies nationallicence Genetic variation nationallicence NF-kappaB nationallicence Etiology nationallicence tagSNPs nationallicence Single nucleotide polymorphisms nationallicence White Kristin Department of Health Sciences Research, Mayo Clinic College of Medicine, 200 First Street SW, 55905, Rochester, MN, USA aut Rider David Department of Health Sciences Research, Mayo Clinic College of Medicine, 200 First Street SW, 55905, Rochester, MN, USA aut Kalli Kimberly Department of Oncology, Mayo Clinic College of Medicine, 200 First Street SW, 55905, Rochester, MN, USA aut Knutson Keith Department of Immunology, Mayo Clinic College of Medicine, 200 First Street SW, 55905, Rochester, MN, USA aut Jarvik Gail University of Washington, Seattle, WA, USA aut Goode Ellen Department of Health Sciences Research, Mayo Clinic College of Medicine, 200 First Street SW, 55905, Rochester, MN, USA aut Cancer Causes & Control Springer Netherlands 22/5(2011-05-01), 785-801 0957-5243 22:5<785 2011 22 10552 https://doi.org/10.1007/s10552-011-9745-4 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10552-011-9745-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- White Kristin Department of Health Sciences Research, Mayo Clinic College of Medicine, 200 First Street SW, 55905, Rochester, MN, USA aut NATIONALLICENCE 700 1- Rider David Department of Health Sciences Research, Mayo Clinic College of Medicine, 200 First Street SW, 55905, Rochester, MN, USA aut NATIONALLICENCE 700 1- Kalli Kimberly Department of Oncology, Mayo Clinic College of Medicine, 200 First Street SW, 55905, Rochester, MN, USA aut NATIONALLICENCE 700 1- Knutson Keith Department of Immunology, Mayo Clinic College of Medicine, 200 First Street SW, 55905, Rochester, MN, USA aut NATIONALLICENCE 700 1- Jarvik Gail University of Washington, Seattle, WA, USA aut NATIONALLICENCE 700 1- Goode Ellen Department of Health Sciences Research, Mayo Clinic College of Medicine, 200 First Street SW, 55905, Rochester, MN, USA aut NATIONALLICENCE 773 0- Cancer Causes & Control Springer Netherlands 22/5(2011-05-01), 785-801 0957-5243 22:5<785 2011 22 10552 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer