caa a22 4500 445315873 CHVBK 20180317142647.0 cr unu---uuuuu 170323e20110501xx s 000 0 eng 10.1007/s10552-011-9750-7 doi (NATIONALLICENCE)springer-10.1007/s10552-011-9750-7 Smoking and alcohol consumption in relation to risk of triple-negative breast cancer in a cohort of postmenopausal women [Elektronische Daten] [Geoffrey Kabat, Mimi Kim, Amanda Phipps, Christopher Li, Catherine Messina, Jean Wactawski-Wende, Lewis Kuller, Michael Simon, Shagufta Yasmeen, Sylvia Wassertheil-Smoller, Thomas Rohan] Purpose: Little is known about the risk factors for triple-negative breast cancer (TNBC), which has a worse prognosis compared to hormone receptor-positive breast cancer. We examined the association of smoking and alcohol intake with TNBC and estrogen receptor-positive (ER+) breast cancer. Methods: Among 148,030 women enrolled in the Women's Health Initiative, 300 TNBC cases and 2,479 ER+ cases were identified over a median of 8.0years of follow-up. Cox proportional hazards models were used to estimate hazard ratios (HR) and 95% confidence intervals (95% CI). Results: Cigarette smoking was not associated with TNBC, whereas drinkers had reduced risk compared to never drinkers. In contrast, both exposures showed slight positive associations with ER+ breast cancer: for women with ≥40 pack-years of smoking, the HR was 1.24, 95% CI 1.06-1.44; for women consuming ≥7 servings of alcohol per week, the HR was 1.26, 95% CI 1.06-1.50. Intakes of wine and hard liquor were also significantly positively associated with ER+ breast cancer. Conclusions: These findings from a large cohort of postmenopausal women suggest that smoking and alcohol consumption are not associated with increased risk of TNBC, but may be modestly associated with increased risk of ER+ breast cancer. Springer Science+Business Media B.V., 2011 Breast neoplasms nationallicence Triple-negative nationallicence Estrogen receptor-positive nationallicence Cigarette smoking nationallicence Alcohol consumption nationallicence Postmenopausal women nationallicence Kabat Geoffrey Department of Epidemiology and Population Health, Albert Einstein College of Medicine, 1300 Morris Park Avenue, 10461, Bronx, NY, USA aut Kim Mimi Department of Epidemiology and Population Health, Albert Einstein College of Medicine, 1300 Morris Park Avenue, 10461, Bronx, NY, USA aut Phipps Amanda Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 98109-4433, Seattle, WA, USA aut Li Christopher Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 98109-4433, Seattle, WA, USA aut Messina Catherine Department of Preventive Medicine, Stony Brook University, 11794, Stony Brook, NY, USA aut Wactawski-Wende Jean Department of Social and Preventive Medicine, School of Public Health and Health Professions, University of Buffalo, 14214, Buffalo, NY, USA aut Kuller Lewis Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, 15261, Pittsburgh, PA, USA aut Simon Michael Department of Oncology, Karmanos Cancer Institute, Wayne State University, 48201, Detroit, MI, USA aut Yasmeen Shagufta Department of Obstetrics and Gynecology, University of California at Davis, 95817, Sacramento, CA, USA aut Wassertheil-Smoller Sylvia Department of Epidemiology and Population Health, Albert Einstein College of Medicine, 1300 Morris Park Avenue, 10461, Bronx, NY, USA aut Rohan Thomas Department of Epidemiology and Population Health, Albert Einstein College of Medicine, 1300 Morris Park Avenue, 10461, Bronx, NY, USA aut Cancer Causes & Control Springer Netherlands 22/5(2011-05-01), 775-783 0957-5243 22:5<775 2011 22 10552 https://doi.org/10.1007/s10552-011-9750-7 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10552-011-9750-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kabat Geoffrey Department of Epidemiology and Population Health, Albert Einstein College of Medicine, 1300 Morris Park Avenue, 10461, Bronx, NY, USA aut NATIONALLICENCE 700 1- Kim Mimi Department of Epidemiology and Population Health, Albert Einstein College of Medicine, 1300 Morris Park Avenue, 10461, Bronx, NY, USA aut NATIONALLICENCE 700 1- Phipps Amanda Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 98109-4433, Seattle, WA, USA aut NATIONALLICENCE 700 1- Li Christopher Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 98109-4433, Seattle, WA, USA aut NATIONALLICENCE 700 1- Messina Catherine Department of Preventive Medicine, Stony Brook University, 11794, Stony Brook, NY, USA aut NATIONALLICENCE 700 1- Wactawski-Wende Jean Department of Social and Preventive Medicine, School of Public Health and Health Professions, University of Buffalo, 14214, Buffalo, NY, USA aut NATIONALLICENCE 700 1- Kuller Lewis Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, 15261, Pittsburgh, PA, USA aut NATIONALLICENCE 700 1- Simon Michael Department of Oncology, Karmanos Cancer Institute, Wayne State University, 48201, Detroit, MI, USA aut NATIONALLICENCE 700 1- Yasmeen Shagufta Department of Obstetrics and Gynecology, University of California at Davis, 95817, Sacramento, CA, USA aut NATIONALLICENCE 700 1- Wassertheil-Smoller Sylvia Department of Epidemiology and Population Health, Albert Einstein College of Medicine, 1300 Morris Park Avenue, 10461, Bronx, NY, USA aut NATIONALLICENCE 700 1- Rohan Thomas Department of Epidemiology and Population Health, Albert Einstein College of Medicine, 1300 Morris Park Avenue, 10461, Bronx, NY, USA aut NATIONALLICENCE 773 0- Cancer Causes & Control Springer Netherlands 22/5(2011-05-01), 775-783 0957-5243 22:5<775 2011 22 10552 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer