caa a22 4500 445315881 CHVBK 20180317142647.0 cr unu---uuuuu 170323e20110501xx s 000 0 eng 10.1007/s10552-011-9751-6 doi (NATIONALLICENCE)springer-10.1007/s10552-011-9751-6 Non-steroidal anti-inflammatory drug and aspirin use and the risk of head and neck cancer: a systematic review [Elektronische Daten] [Jessica Wilson, Lesley Anderson, Liam Murray, Carmel Hughes] Background: Use of non-steroidal anti-inflammatory drugs (NSAIDs) has been associated with a reduced risk of several cancers. This is thought to be through the inhibitory action on the cyclooxygenase (COX) enzyme, COX-2. Evidence for NSAIDs preventing head and neck cancer (HNC) is conflicting. We conducted a systematic literature review to investigate the association between NSAID/aspirin use and risk of head and neck cancer (HNC). Methodology: MEDLINE, EMBASE, PubMed, Cochrane Library, and Web of Science were systematically searched using terms for NSAIDs/aspirin, HNC, and observational/intervention study designs to identify studies published by December 2009. Results: Of 9,268 articles identified, two population-based prescribing database studies and three case-control studies met the selection criteria. The studies investigated different HNC sites. Only one study found a significant protective association of aspirin use with HNC risk (OR 0.75, 95% CI 0.58-0.96), and one showed a significantly increased risk of oral/oropharyngeal cancer with non-low-dose aspirin NSAID use (OR 3.5, 95% CI 1.8-6.7). Many of the studies identified lacked information on important confounding factors. Conclusion: No definitive conclusion on the effect of NSAIDs/aspirin on HNC risk was possible. Aspirin may protect against HNC, although further robust large-scale studies are required to clarify any possible association. Springer Science+Business Media B.V., 2011 Head and neck cancer nationallicence Non-steroidal anti-inflammatory drugs nationallicence Aspirin nationallicence Systematic review nationallicence COX-2 nationallicence Wilson Jessica Centre for Public Health, School of Medicine Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, UK aut Anderson Lesley Centre for Public Health, School of Medicine Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, UK aut Murray Liam Centre for Public Health, School of Medicine Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, UK aut Hughes Carmel School of Pharmacy, Queen's University Belfast, Belfast, UK aut Cancer Causes & Control Springer Netherlands 22/5(2011-05-01), 803-810 0957-5243 22:5<803 2011 22 10552 https://doi.org/10.1007/s10552-011-9751-6 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10552-011-9751-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Wilson Jessica Centre for Public Health, School of Medicine Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, UK aut NATIONALLICENCE 700 1- Anderson Lesley Centre for Public Health, School of Medicine Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, UK aut NATIONALLICENCE 700 1- Murray Liam Centre for Public Health, School of Medicine Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, UK aut NATIONALLICENCE 700 1- Hughes Carmel School of Pharmacy, Queen's University Belfast, Belfast, UK aut NATIONALLICENCE 773 0- Cancer Causes & Control Springer Netherlands 22/5(2011-05-01), 803-810 0957-5243 22:5<803 2011 22 10552 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer