caa a22 4500 445315903 CHVBK 20180317142647.0 cr unu---uuuuu 170323e20110501xx s 000 0 eng 10.1007/s10552-011-9746-3 doi (NATIONALLICENCE)springer-10.1007/s10552-011-9746-3 Genital powder exposure and the risk of epithelial ovarian cancer [Elektronische Daten] [Karin Rosenblatt, Noel Weiss, Kara Cushing-Haugen, Kristine Wicklund, Mary Rossing] Background: We conducted a population-based, case-control study to examine the association between the use of genital powder and ovarian cancer risk, including measures of extent and timing of exposure. We also assessed the relationship of powder use with risk of disease subtypes according to histology and degree of malignancy. Methods: Information was collected during in-person interviews with 812 women with epithelial ovarian cancer diagnosed in western Washington State from 2002 to 2005 and 1,313 controls. Logistic regression was used to calculate odds ratios (ORs) and 95% confidence intervals (CIs). Results: Overall, the perineal use of powder after bathing was associated with a slightly increased ovarian cancer risk (OR=1.27, 95% CI: 0.97-1.66), which was most evident among women with borderline tumors (OR=1.55, 95% CI: 1.02-2.37). We noted no clear pattern of risk increase on the basis of the extent of use, assessed as years in which powder was used, or as lifetime number of applications for invasive or borderline tumors, or their histologic subtypes. There was no alteration in the risk of ovarian cancer associated with other types of powder exposure (e.g., on sanitary napkins or diaphragms). Conclusions: The International Agency for Research on Cancer has designated perineal exposure to talc (via the application of genital powders) as a possible carcinogen in women. A modest association of ovarian cancer with this exposure was seen in our study and in some previous ones, but that association generally has not been consistent within or among studies. Therefore, no stronger adjective than "possible” appears warranted at this time. Springer Science+Business Media B.V., 2011 Ovarian neoplasms nationallicence Talc nationallicence Epidemiology nationallicence Rosenblatt Karin Department of Kinesiology and Community Health, University of Illinois at Urbana Champaign, IL, Champaign, USA aut Weiss Noel Program in Epidemiology, Fred Hutchinson Cancer Research Center, P.O. Box 19024, 98108-1024, Seattle, WA, USA aut Cushing-Haugen Kara Program in Epidemiology, Fred Hutchinson Cancer Research Center, P.O. Box 19024, 98108-1024, Seattle, WA, USA aut Wicklund Kristine Program in Epidemiology, Fred Hutchinson Cancer Research Center, P.O. Box 19024, 98108-1024, Seattle, WA, USA aut Rossing Mary Program in Epidemiology, Fred Hutchinson Cancer Research Center, P.O. Box 19024, 98108-1024, Seattle, WA, USA aut Cancer Causes & Control Springer Netherlands 22/5(2011-05-01), 737-742 0957-5243 22:5<737 2011 22 10552 https://doi.org/10.1007/s10552-011-9746-3 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10552-011-9746-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Rosenblatt Karin Department of Kinesiology and Community Health, University of Illinois at Urbana Champaign, IL, Champaign, USA aut NATIONALLICENCE 700 1- Weiss Noel Program in Epidemiology, Fred Hutchinson Cancer Research Center, P.O. Box 19024, 98108-1024, Seattle, WA, USA aut NATIONALLICENCE 700 1- Cushing-Haugen Kara Program in Epidemiology, Fred Hutchinson Cancer Research Center, P.O. Box 19024, 98108-1024, Seattle, WA, USA aut NATIONALLICENCE 700 1- Wicklund Kristine Program in Epidemiology, Fred Hutchinson Cancer Research Center, P.O. Box 19024, 98108-1024, Seattle, WA, USA aut NATIONALLICENCE 700 1- Rossing Mary Program in Epidemiology, Fred Hutchinson Cancer Research Center, P.O. Box 19024, 98108-1024, Seattle, WA, USA aut NATIONALLICENCE 773 0- Cancer Causes & Control Springer Netherlands 22/5(2011-05-01), 737-742 0957-5243 22:5<737 2011 22 10552 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer