caa a22 4500 445315911 CHVBK 20180317142647.0 cr unu---uuuuu 170323e20110501xx s 000 0 eng 10.1007/s10552-011-9747-2 doi (NATIONALLICENCE)springer-10.1007/s10552-011-9747-2 Metabolic factors and risk of thyroid cancer in the Metabolic syndrome and Cancer project (Me-Can) [Elektronische Daten] [Martin Almquist, Dorthe Johansen, Tone Björge, Hanno Ulmer, Björn Lindkvist, Tanja Stocks, Göran Hallmans, Anders Engeland, Kilian Rapp, Håkan Jonsson, Randi Selmer, Guenter Diem, Christel Häggström, Steinar Tretli, Pär Stattin, Jonas Manjer] Objective: To investigate metabolic factors and their possible impact on risk of thyroid cancer. Methods: A prospective cohort study was conducted based on seven population-based cohorts in Norway, Austria, and Sweden, in the Metabolic syndrome and Cancer project (Me-Can). Altogether 578,700 men and women with a mean age of 44.0years at baseline were followed for on average 12.0years. Relative risk of incident thyroid cancer was assessed by levels of BMI, blood pressure, and blood levels of glucose, cholesterol, triglycerides, and by a combined metabolic syndrome (MetS) score. Risk estimates were investigated for quintiles, and a z score distribution of exposures was analyzed using Cox proportional hazards regression. Results: During follow-up, 255 women and 133 men were diagnosed with thyroid cancer. In women, there was an inverse association between glucose and thyroid cancer risk, with adjusted RR: 95% CI was 0.61 (0.41-0.90), p trend=0.02 in the fifth versus the first quintile, and a positive association between BMI and thyroid cancer risk with a significant trend over quintiles. There was no association between the other metabolic factors, single or combined (Met-S), and thyroid cancer. Conclusion: In women, BMI was positively, while blood glucose levels were inversely, associated with thyroid cancer. Springer Science+Business Media B.V., 2011 Thyroid cancer nationallicence Epidemiology nationallicence Metabolic syndrome nationallicence Cohort study nationallicence Almquist Martin Department of Surgery, Skåne University Hospital Lund and Lund University, 221 85, Lund, Sweden aut Johansen Dorthe Department of Surgery, Skåne University Hospital Malmö and Lund University, Malmö, Sweden aut Björge Tone Norwegian Institute of Public Health, Oslo/Bergen, Norway aut Ulmer Hanno Department of Medical Statistics, Informatics and Health Economics, Innsbruck Medical University, Innsbruck, Austria aut Lindkvist Björn Department of Internal Medicine, Division of Gastroenterology and Hepatology, Sahlgrenska University Hospital, Göteborg, Sweden aut Stocks Tanja Department of Surgical and Perioperative Sciences, Urology and Andrology, Umeå University, Umeå, Sweden aut Hallmans Göran Department of Public Health and Clinical Medicine, Nutritional Research, Umeå University, Umeå, Sweden aut Engeland Anders Norwegian Institute of Public Health, Oslo/Bergen, Norway aut Rapp Kilian Institute of Epidemiology, Ulm University, Ulm, Germany aut Jonsson Håkan Department of Radiation Science, Oncology, Umeå University, Umeå, Sweden aut Selmer Randi Norwegian Institute of Public Health, Oslo/Bergen, Norway aut Diem Guenter Agency for Social- and Preventive Medicine, Bregenz, Austria aut Häggström Christel Department of Surgical and Perioperative Sciences, Urology and Andrology, Umeå University, Umeå, Sweden aut Tretli Steinar Cancer Registry of Norway, Institute of Population-based Cancer Research, Oslo, Norway aut Stattin Pär Department of Surgical and Perioperative Sciences, Urology and Andrology, Umeå University, Umeå, Sweden aut Manjer Jonas Department of Surgery, Skåne University Hospital Malmö and Lund University, Malmö, Sweden aut Cancer Causes & Control Springer Netherlands 22/5(2011-05-01), 743-751 0957-5243 22:5<743 2011 22 10552 https://doi.org/10.1007/s10552-011-9747-2 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10552-011-9747-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Almquist Martin Department of Surgery, Skåne University Hospital Lund and Lund University, 221 85, Lund, Sweden aut NATIONALLICENCE 700 1- Johansen Dorthe Department of Surgery, Skåne University Hospital Malmö and Lund University, Malmö, Sweden aut NATIONALLICENCE 700 1- Björge Tone Norwegian Institute of Public Health, Oslo/Bergen, Norway aut NATIONALLICENCE 700 1- Ulmer Hanno Department of Medical Statistics, Informatics and Health Economics, Innsbruck Medical University, Innsbruck, Austria aut NATIONALLICENCE 700 1- Lindkvist Björn Department of Internal Medicine, Division of Gastroenterology and Hepatology, Sahlgrenska University Hospital, Göteborg, Sweden aut NATIONALLICENCE 700 1- Stocks Tanja Department of Surgical and Perioperative Sciences, Urology and Andrology, Umeå University, Umeå, Sweden aut NATIONALLICENCE 700 1- Hallmans Göran Department of Public Health and Clinical Medicine, Nutritional Research, Umeå University, Umeå, Sweden aut NATIONALLICENCE 700 1- Engeland Anders Norwegian Institute of Public Health, Oslo/Bergen, Norway aut NATIONALLICENCE 700 1- Rapp Kilian Institute of Epidemiology, Ulm University, Ulm, Germany aut NATIONALLICENCE 700 1- Jonsson Håkan Department of Radiation Science, Oncology, Umeå University, Umeå, Sweden aut NATIONALLICENCE 700 1- Selmer Randi Norwegian Institute of Public Health, Oslo/Bergen, Norway aut NATIONALLICENCE 700 1- Diem Guenter Agency for Social- and Preventive Medicine, Bregenz, Austria aut NATIONALLICENCE 700 1- Häggström Christel Department of Surgical and Perioperative Sciences, Urology and Andrology, Umeå University, Umeå, Sweden aut NATIONALLICENCE 700 1- Tretli Steinar Cancer Registry of Norway, Institute of Population-based Cancer Research, Oslo, Norway aut NATIONALLICENCE 700 1- Stattin Pär Department of Surgical and Perioperative Sciences, Urology and Andrology, Umeå University, Umeå, Sweden aut NATIONALLICENCE 700 1- Manjer Jonas Department of Surgery, Skåne University Hospital Malmö and Lund University, Malmö, Sweden aut NATIONALLICENCE 773 0- Cancer Causes & Control Springer Netherlands 22/5(2011-05-01), 743-751 0957-5243 22:5<743 2011 22 10552 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer