caa a22 4500 44531592X CHVBK 20180317142647.0 cr unu---uuuuu 170323e20110501xx s 000 0 eng 10.1007/s10552-011-9741-8 doi (NATIONALLICENCE)springer-10.1007/s10552-011-9741-8 Placental characteristics as a proxy measure of serum hormone and protein levels during pregnancy with a male fetus [Elektronische Daten] [Britton Trabert, Matthew Longnecker, Barry Graubard, Mark Klebanoff, Frank Stanczyk, Katherine McGlynn] Objective: In utero exposure to steroid hormones may be related to risk of some cancers such as testicular germ cell tumors (TGCT). To determine whether placental characteristics are good surrogate measures of maternal biomarker levels, we evaluated the correlations in mothers of sons at higher (whites, n=150) and lower (blacks, n=150) risk of TGCT. Associations with birth weight were also examined. Methods: All mothers, participants in the Collaborative Perinatal Project, were primigravidas who gave birth to male singletons. Associations between placental weight and placental thickness and third-trimester biomarker levels were evaluated using linear regression. Partial correlation coefficients for placental characteristics and birth weight were also estimated. Results: Placental weight was positively correlated with alpha-fetoprotein (AFP), sex hormone-binding globulin (SHBG), testosterone, estradiol and estriol in whites, and AFP and estriol in blacks. Placental thickness was not associated with any biomarker. After adjustment for placental weight, birth weight was not correlated with any biomarker. Conclusions: In these data, placental weight was modestly correlated with third-trimester biomarker level; however, it appeared to be a better surrogate for third-trimester biomarker level than birth weight. Placental thickness had limited utility as a surrogate measure for biomarker levels. Springer Science+Business Media B.V. (outside the USA), 2011 Cancer risk nationallicence Placental weight nationallicence Birth weight nationallicence Maternal hormones nationallicence Trabert Britton Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, 6120 Executive Boulevard, Suite 550, 20852-7234, Rockville, MD, USA aut Longnecker Matthew Epidemiology Branch, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, NC, USA aut Graubard Barry Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Rockville, MD, USA aut Klebanoff Mark Division of Epidemiology, Statistics and Prevention Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, DHHS, Bethesda, MD, USA aut Stanczyk Frank Departments of Obstetrics and Gynecology, and Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA, USA aut McGlynn Katherine Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, 6120 Executive Boulevard, Suite 550, 20852-7234, Rockville, MD, USA aut Cancer Causes & Control Springer Netherlands 22/5(2011-05-01), 689-695 0957-5243 22:5<689 2011 22 10552 https://doi.org/10.1007/s10552-011-9741-8 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10552-011-9741-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Trabert Britton Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, 6120 Executive Boulevard, Suite 550, 20852-7234, Rockville, MD, USA aut NATIONALLICENCE 700 1- Longnecker Matthew Epidemiology Branch, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, NC, USA aut NATIONALLICENCE 700 1- Graubard Barry Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Rockville, MD, USA aut NATIONALLICENCE 700 1- Klebanoff Mark Division of Epidemiology, Statistics and Prevention Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, DHHS, Bethesda, MD, USA aut NATIONALLICENCE 700 1- Stanczyk Frank Departments of Obstetrics and Gynecology, and Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA, USA aut NATIONALLICENCE 700 1- McGlynn Katherine Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, 6120 Executive Boulevard, Suite 550, 20852-7234, Rockville, MD, USA aut NATIONALLICENCE 773 0- Cancer Causes & Control Springer Netherlands 22/5(2011-05-01), 689-695 0957-5243 22:5<689 2011 22 10552 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer