caa a22 4500 445315938 CHVBK 20180317142647.0 cr unu---uuuuu 170323e20110501xx s 000 0 eng 10.1007/s10552-011-9740-9 doi (NATIONALLICENCE)springer-10.1007/s10552-011-9740-9 Relationship between height at diagnosis and bone tumours in young people: a meta-analysis [Elektronische Daten] [Ramandeep Arora, Evangelos Kontopantelis, Robert Alston, Tim Eden, Marco Geraci, Jillian Birch] Objective: Some evidence exists that patients with osteosarcoma and Ewing sarcoma are taller than the general population. However, previous studies are under-powered, lack comprehensive data and show inconsistencies. Methods: Relevant studies linking osteosarcoma and Ewing sarcoma with height at diagnosis were identified in two major online databases, Medline (1950 to 2009) and Embase (1980 to 2009). Outcomes in individual studies were reported as standard deviation (SD) scores or percentages of study population with height at diagnosis above the median of the reference population. We performed separate random-effects meta-analyses for each outcome and tumour type. Results: 14 studies examined the height of patients with osteosarcoma or Ewing sarcoma. Meta-analyses on SD scores found patients with osteosarcoma were 0.260 SD (95% CI: 0.088-0.432) taller than the reference population (five studies). A meta-analysis on percentages found 62% (95% CI: 57%-67%) of patients were estimated to have a height above the median (six studies). Patients with Ewing sarcoma were 0.096 SD (95% CI 0.004-0.188) taller (four studies). Only one study reported the percentage of Ewing sarcoma patients with height above the median. Conclusion: The average height of patients with osteosarcoma, but not Ewing sarcoma, was significantly above the average height of the reference population by 2-3 centimetres. The observed differences indicate the involvement of pubertal longitudinal bone growth in osteosarcoma development while different biological pathways could be relevant for Ewing sarcoma. Springer Science+Business Media B.V., 2011 Osteosarcoma nationallicence Ewing sarcoma nationallicence Growth nationallicence Body height nationallicence Meta-analysis nationallicence Arora Ramandeep Cancer Research UK Paediatric and Familial Cancer Research Group, 1.906, University of Manchester, Stopford Building, Oxford Road, M13 9PL, Manchester, UK aut Kontopantelis Evangelos Health Sciences Primary Care Research Group, University of Manchester, Manchester, UK aut Alston Robert Cancer Research UK Paediatric and Familial Cancer Research Group, 1.906, University of Manchester, Stopford Building, Oxford Road, M13 9PL, Manchester, UK aut Eden Tim Academic Unit of Paediatric and Adolescent Oncology, University of Manchester, Manchester, UK aut Geraci Marco MRC Centre of Epidemiology for Child Health, UCL Institute of Child Health, London, UK aut Birch Jillian Cancer Research UK Paediatric and Familial Cancer Research Group, 1.906, University of Manchester, Stopford Building, Oxford Road, M13 9PL, Manchester, UK aut Cancer Causes & Control Springer Netherlands 22/5(2011-05-01), 681-688 0957-5243 22:5<681 2011 22 10552 https://doi.org/10.1007/s10552-011-9740-9 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10552-011-9740-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Arora Ramandeep Cancer Research UK Paediatric and Familial Cancer Research Group, 1.906, University of Manchester, Stopford Building, Oxford Road, M13 9PL, Manchester, UK aut NATIONALLICENCE 700 1- Kontopantelis Evangelos Health Sciences Primary Care Research Group, University of Manchester, Manchester, UK aut NATIONALLICENCE 700 1- Alston Robert Cancer Research UK Paediatric and Familial Cancer Research Group, 1.906, University of Manchester, Stopford Building, Oxford Road, M13 9PL, Manchester, UK aut NATIONALLICENCE 700 1- Eden Tim Academic Unit of Paediatric and Adolescent Oncology, University of Manchester, Manchester, UK aut NATIONALLICENCE 700 1- Geraci Marco MRC Centre of Epidemiology for Child Health, UCL Institute of Child Health, London, UK aut NATIONALLICENCE 700 1- Birch Jillian Cancer Research UK Paediatric and Familial Cancer Research Group, 1.906, University of Manchester, Stopford Building, Oxford Road, M13 9PL, Manchester, UK aut NATIONALLICENCE 773 0- Cancer Causes & Control Springer Netherlands 22/5(2011-05-01), 681-688 0957-5243 22:5<681 2011 22 10552 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer