caa a22 4500 445315954 CHVBK 20180317142647.0 cr unu---uuuuu 170323e20110501xx s 000 0 eng 10.1007/s10552-011-9739-2 doi (NATIONALLICENCE)springer-10.1007/s10552-011-9739-2 Anatomic sites at elevated risk of second primary cancer after an index head and neck cancer [Elektronische Daten] [Luc Morris, Andrew Sikora, Richard Hayes, Snehal Patel, Ian Ganly] Background: Patients with head and neck squamous cell carcinoma (HNSCC) are at significantly elevated risk of second primary malignancies (SPM), most commonly within the head and neck, lung, and esophagus (HNLE). Our objectives were to quantify the excess risk of SPM across all anatomic sites in which SPM risk is meaningfully elevated, including non-HNLE sites, in a large cohort of US patients. Methods: Population-based analysis of 75,087 patients with HNSCC in the SEER program, quantifying excess SPM risk by integrating relative (standardized incidence ratio; SIR) and absolute (excess absolute risk per 10,000 person-years at risk; EAR) statistics. Results: In HNSCC patients, the SIR of a second primary solid cancer was 2.2 (95% CI 2.1-2.2), corresponding to EAR of 167.7 additional cases per 10,000 person-years at risk. Over 1year, 60 patients would need to be followed to observe one excess SPM. Lung cancer burden was most markedly elevated in absolute terms (EAR=75.2), followed by HN (EAR=59.8), esophageal (EAR=14.2), and colorectal (EAR=4.3) cancers. Lesser but significant excess risks were also observed for cancers of the bladder, liver, stomach, pancreas, kidney, salivary glands, nasopharynx, uterine cervix, and lymphoma. Conclusions: Data from a large population-based US cohort reveals that HNSCC patients experience markedly excess risk of SPM, predominantly in the HNLE sites. Furthermore, the risk of SPM is also meaningfully elevated, although to a lesser degree, in multiple other tobacco-associated sites. Springer Science+Business Media B.V., 2011 Second primary nationallicence Malignancy nationallicence Cancer nationallicence Head and neck nationallicence Lung nationallicence Esophagus nationallicence Colon nationallicence Morris Luc Head and Neck Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, 10021, New York, NY, USA aut Sikora Andrew Department of Otolaryngology-Head and Neck Surgery, Mount Sinai School of Medicine, New York, NY, USA aut Hayes Richard Division of Epidemiology, New York University Cancer Institute, New York University School of Medicine, New York, NY, USA aut Patel Snehal Head and Neck Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, 10021, New York, NY, USA aut Ganly Ian Head and Neck Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, 10021, New York, NY, USA aut Cancer Causes & Control Springer Netherlands 22/5(2011-05-01), 671-679 0957-5243 22:5<671 2011 22 10552 https://doi.org/10.1007/s10552-011-9739-2 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10552-011-9739-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Morris Luc Head and Neck Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, 10021, New York, NY, USA aut NATIONALLICENCE 700 1- Sikora Andrew Department of Otolaryngology-Head and Neck Surgery, Mount Sinai School of Medicine, New York, NY, USA aut NATIONALLICENCE 700 1- Hayes Richard Division of Epidemiology, New York University Cancer Institute, New York University School of Medicine, New York, NY, USA aut NATIONALLICENCE 700 1- Patel Snehal Head and Neck Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, 10021, New York, NY, USA aut NATIONALLICENCE 700 1- Ganly Ian Head and Neck Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, 10021, New York, NY, USA aut NATIONALLICENCE 773 0- Cancer Causes & Control Springer Netherlands 22/5(2011-05-01), 671-679 0957-5243 22:5<671 2011 22 10552 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer