caa a22 4500 445316039 CHVBK 20180317142647.0 cr unu---uuuuu 170323e20110201xx s 000 0 eng 10.1007/s10552-010-9697-0 doi (NATIONALLICENCE)springer-10.1007/s10552-010-9697-0 Serum triglycerides and cancer risk in the metabolic syndrome and cancer (Me-Can) collaborative study [Elektronische Daten] [Wegene Borena, Tanja Stocks, Håkan Jonsson, Susanne Strohmaier, Gabriele Nagel, Tone Bjørge, Jonas Manjer, Göran Hallmans, Randi Selmer, Martin Almquist, Christel Häggström, Anders Engeland, Steinar Tretli, Hans Concin, Alexander Strasak, Pär Stattin, Hanno Ulmer] Objective: To assess the association between serum triglyceride levels and cancer risk. Methods: The metabolic syndrome and cancer project (Me-Can) includes cohorts from Norway, Austria, and Sweden; the current study included data on 257,585 men and 256,512 women. The mean age at study entry was 43.8years for men and 44.2years for women. The mean follow-up time was 13.4years (SD=8.5) for men and 11.9years (SD=7.2) for women. Excluding the first year of follow-up, 23,060 men and 15,686 women were diagnosed with cancer. Cox regression models were used to calculate relative risk (RR) of cancer for triglyceride levels in quintiles and as a continuous variable. RRs were corrected for random error by use of regression dilution ratio. Results: Relative risk for top quintile versus bottom quintile of triglycerides of overall cancer was 1.16 (95% confidence interval 1.06-1.26) in men and 1.15 (1.05-1.27) in women. For specific cancers, significant increases for top quintile versus bottom quintile of triglycerides among men were found for cancers of the colon, respiratory tract, the kidney, melanoma and thyroid and among women, for respiratory, cervical, and non-melanoma skin cancers. Conclusion: Data from our study provided evidence for a possible role of serum triglycerides in cancer development. Springer Science+Business Media B.V., 2010 Lipids nationallicence Prospective study nationallicence Cancer incidence nationallicence Borena Wegene Department of Medical Statistics, Informatics and Health Economics, Innsbruck Medical University, Schoepfstrasse 41, 6020, Innsbruck, Austria aut Stocks Tanja Department of Surgical and Perioperative Sciences, Urology and Andrology, Umeå University, Umeå, Sweden aut Jonsson Håkan Department of Radiation Sciences, Oncology, Umeå University, Umeå, Sweden aut Strohmaier Susanne Department of Medical Statistics, Informatics and Health Economics, Innsbruck Medical University, Schoepfstrasse 41, 6020, Innsbruck, Austria aut Nagel Gabriele Institute of Epidemiology, Ulm University, Ulm, Germany aut Bjørge Tone Department of Public Health and Primary Health Care, University of Bergen, Bergen, Norway aut Manjer Jonas Department of Surgery, Malmö University Hospital, Lund University, Malmö, Sweden aut Hallmans Göran Department of Public Health and Clinical Medicine, Nutritional Research, Umeå University, Umeå, Sweden aut Selmer Randi Norwegian Institute of Public Health, Oslo/Bergen, Norway aut Almquist Martin Department of Surgery, Lund University Hospital, Lund University, Malmö, Sweden aut Häggström Christel Department of Surgical and Perioperative Sciences, Urology and Andrology, Umeå University, Umeå, Sweden aut Engeland Anders Norwegian Institute of Public Health, Oslo/Bergen, Norway aut Tretli Steinar Cancer Registry of Norway, Institute of Population-Based Cancer Research, Montebello, 0310, Oslo, Norway aut Concin Hans Agency for Preventive and Social Medicine, Bregenz, Austria aut Strasak Alexander Department of Medical Statistics, Informatics and Health Economics, Innsbruck Medical University, Schoepfstrasse 41, 6020, Innsbruck, Austria aut Stattin Pär Department of Surgical and Perioperative Sciences, Urology and Andrology, Umeå University, Umeå, Sweden aut Ulmer Hanno Department of Medical Statistics, Informatics and Health Economics, Innsbruck Medical University, Schoepfstrasse 41, 6020, Innsbruck, Austria aut Cancer Causes & Control Springer Netherlands 22/2(2011-02-01), 291-299 0957-5243 22:2<291 2011 22 10552 https://doi.org/10.1007/s10552-010-9697-0 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10552-010-9697-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Borena Wegene Department of Medical Statistics, Informatics and Health Economics, Innsbruck Medical University, Schoepfstrasse 41, 6020, Innsbruck, Austria aut NATIONALLICENCE 700 1- Stocks Tanja Department of Surgical and Perioperative Sciences, Urology and Andrology, Umeå University, Umeå, Sweden aut NATIONALLICENCE 700 1- Jonsson Håkan Department of Radiation Sciences, Oncology, Umeå University, Umeå, Sweden aut NATIONALLICENCE 700 1- Strohmaier Susanne Department of Medical Statistics, Informatics and Health Economics, Innsbruck Medical University, Schoepfstrasse 41, 6020, Innsbruck, Austria aut NATIONALLICENCE 700 1- Nagel Gabriele Institute of Epidemiology, Ulm University, Ulm, Germany aut NATIONALLICENCE 700 1- Bjørge Tone Department of Public Health and Primary Health Care, University of Bergen, Bergen, Norway aut NATIONALLICENCE 700 1- Manjer Jonas Department of Surgery, Malmö University Hospital, Lund University, Malmö, Sweden aut NATIONALLICENCE 700 1- Hallmans Göran Department of Public Health and Clinical Medicine, Nutritional Research, Umeå University, Umeå, Sweden aut NATIONALLICENCE 700 1- Selmer Randi Norwegian Institute of Public Health, Oslo/Bergen, Norway aut NATIONALLICENCE 700 1- Almquist Martin Department of Surgery, Lund University Hospital, Lund University, Malmö, Sweden aut NATIONALLICENCE 700 1- Häggström Christel Department of Surgical and Perioperative Sciences, Urology and Andrology, Umeå University, Umeå, Sweden aut NATIONALLICENCE 700 1- Engeland Anders Norwegian Institute of Public Health, Oslo/Bergen, Norway aut NATIONALLICENCE 700 1- Tretli Steinar Cancer Registry of Norway, Institute of Population-Based Cancer Research, Montebello, 0310, Oslo, Norway aut NATIONALLICENCE 700 1- Concin Hans Agency for Preventive and Social Medicine, Bregenz, Austria aut NATIONALLICENCE 700 1- Strasak Alexander Department of Medical Statistics, Informatics and Health Economics, Innsbruck Medical University, Schoepfstrasse 41, 6020, Innsbruck, Austria aut NATIONALLICENCE 700 1- Stattin Pär Department of Surgical and Perioperative Sciences, Urology and Andrology, Umeå University, Umeå, Sweden aut NATIONALLICENCE 700 1- Ulmer Hanno Department of Medical Statistics, Informatics and Health Economics, Innsbruck Medical University, Schoepfstrasse 41, 6020, Innsbruck, Austria aut NATIONALLICENCE 773 0- Cancer Causes & Control Springer Netherlands 22/2(2011-02-01), 291-299 0957-5243 22:2<291 2011 22 10552 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 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