caa a22 4500 445316063 CHVBK 20180317142647.0 cr unu---uuuuu 170323e20110201xx s 000 0 eng 10.1007/s10552-010-9690-7 doi (NATIONALLICENCE)springer-10.1007/s10552-010-9690-7 Energy intake and dietary patterns in childhood and throughout adulthood and mammographic density: results from a British prospective cohort [Elektronische Daten] [Gita Mishra, Isabel dos Santos Silva, Sarah McNaughton, Alison Stephen, Diana Kuh] Objectives: To examine the role of energy intake and dietary patterns in childhood and throughout adulthood on subsequent mammographic density. Methods: Prospective data were available from a cohort of 1161 British women followed up since their birth in 1946. Dietary intakes at age 4years were determined by 24-hour recalls and during adulthood, average food consumed at ages 36 and 43years by 5-day food records. Dietary patterns were determined by factor analysis. Associations between energy intake, dietary patterns, and percent breast density were investigated using regression analysis. Results: During adulthood, energy intake was positively associated with percent breast density (adjusted regression coefficient [per SD) (95% CI): 0.12 (0.01, 0.23)]. The effect of the high fat and sugar dietary pattern remained similar when adjusted for total energy intake [0.06 (−0.01, 0.13)]. There was no evidence of an associations for the patterns low fat, high fiber pattern 0.03 (−0.04, 0.11); the alcohol and fish −0.02 (−0.13, 0.17); meat, potatoes, and vegetables −0.03 (−0.10, 0.04). No association was found for dietary pattern at age 4 and percent breast density. Conclusions: This study supports the hypothesis that overall energy intake during middle life is a determinant of subsequent mammographic breast density measured 15years later. Springer Science+Business Media B.V., 2010 Diet nationallicence Fat nationallicence Energy nationallicence Sugar nationallicence Mammographic breast density nationallicence MRC NSHD : Medical Research Council National Survey of Health and Development nationallicence NHS : National Health Service nationallicence FFQ : Food frequency questionnaires nationallicence UK : United Kingdom nationallicence HT : Hormone therapy nationallicence BMI : Body mass index nationallicence Mishra Gita MRC Unit for Lifelong Health and Ageing, Department of Epidemiology and Public Health, University College London, London, UK aut dos Santos Silva Isabel Cancer Research UK Epidemiology and Genetics Group, Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, Bloomsbury, London, UK aut McNaughton Sarah Centre for Physical Activity and Nutrition Research, Deakin University, 3125, Melbourne, VIC, Australia aut Stephen Alison MRC Human Nutrition Research, Elsie Widdowson Laboratory, Cambridge, UK aut Kuh Diana MRC Unit for Lifelong Health and Ageing, Department of Epidemiology and Public Health, University College London, London, UK aut Cancer Causes & Control Springer Netherlands 22/2(2011-02-01), 227-235 0957-5243 22:2<227 2011 22 10552 https://doi.org/10.1007/s10552-010-9690-7 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10552-010-9690-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Mishra Gita MRC Unit for Lifelong Health and Ageing, Department of Epidemiology and Public Health, University College London, London, UK aut NATIONALLICENCE 700 1- dos Santos Silva Isabel Cancer Research UK Epidemiology and Genetics Group, Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, Bloomsbury, London, UK aut NATIONALLICENCE 700 1- McNaughton Sarah Centre for Physical Activity and Nutrition Research, Deakin University, 3125, Melbourne, VIC, Australia aut NATIONALLICENCE 700 1- Stephen Alison MRC Human Nutrition Research, Elsie Widdowson Laboratory, Cambridge, UK aut NATIONALLICENCE 700 1- Kuh Diana MRC Unit for Lifelong Health and Ageing, Department of Epidemiology and Public Health, University College London, London, UK aut NATIONALLICENCE 773 0- Cancer Causes & Control Springer Netherlands 22/2(2011-02-01), 227-235 0957-5243 22:2<227 2011 22 10552 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer