caa a22 4500 445316071 CHVBK 20180317142647.0 cr unu---uuuuu 170323e20110201xx s 000 0 eng 10.1007/s10552-010-9689-0 doi (NATIONALLICENCE)springer-10.1007/s10552-010-9689-0 Physical activity and endometrial cancer in a population-based case-control study [Elektronische Daten] [Hannah Arem, Melinda Irwin, Yang Zhou, Lingeng Lu, Harvey Risch, Herbert Yu] Introduction: Published studies of physical activity, BMI, and endometrial cancer risk show conflicting results and many do not report on reliability or validity of physical activity questionnaires. Methods: We collected physical activity data on 667 incident cases of endometrial cancer and 662 age-matched controls. Interview-administered questionnaires, collecting demographic and lifestyle information, including a validated questionnaire for physical activity. We performed unconditional logistic regression to examine the relationship between moderate- to vigorous-intensity sports/recreational physical activity (MV PA), sit time, and endometrial cancer risk. Results: Compared to women reporting 0 metabolic equivalent (MET) hours per week of MV PA, those who reported 7.5 MET h/wk or more had a 34% lower endometrial cancer risk (odds ratio (OR)=0.66, 95% CI 0.50-0.87) after adjusting for risk factors including BMI. Those women sitting more than 8h per day had a 52% increased odds (95% CI 1.07-2.16) of endometrial cancer compared to those sitting less than 4h per day. We created a composite measure of physical activity and BMI and found that women with a BMI <25 and activity levels ≥7.5 MET h/wk had a 73% lower endometrial cancer risk (OR=0.27, 95% CI 0.18-0.39) compared with the reference group of overweight (BMI ≥25) and sedentary (MET h/wk=0). Conclusion: Our data support an inverse, independent association between physical activity and endometrial cancer risk after adjusting for BMI and other risk factors. Springer Science+Business Media B.V., 2010 Physical activity nationallicence Endometrial cancer nationallicence BMI nationallicence Arem Hannah Department of Chronic Disease Epidemiology, Yale School of Public Health, 60 College St, Room 428, PO Box 208034, 06520-8034, New Haven, CT, USA aut Irwin Melinda Department of Chronic Disease Epidemiology, Yale School of Public Health, 60 College St, Room 428, PO Box 208034, 06520-8034, New Haven, CT, USA aut Zhou Yang Department of Chronic Disease Epidemiology, Yale School of Public Health, 60 College St, Room 428, PO Box 208034, 06520-8034, New Haven, CT, USA aut Lu Lingeng Department of Chronic Disease Epidemiology, Yale School of Public Health, 60 College St, Room 428, PO Box 208034, 06520-8034, New Haven, CT, USA aut Risch Harvey Department of Chronic Disease Epidemiology, Yale School of Public Health, 60 College St, Room 428, PO Box 208034, 06520-8034, New Haven, CT, USA aut Yu Herbert Department of Chronic Disease Epidemiology, Yale School of Public Health, 60 College St, Room 428, PO Box 208034, 06520-8034, New Haven, CT, USA aut Cancer Causes & Control Springer Netherlands 22/2(2011-02-01), 219-226 0957-5243 22:2<219 2011 22 10552 https://doi.org/10.1007/s10552-010-9689-0 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10552-010-9689-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Arem Hannah Department of Chronic Disease Epidemiology, Yale School of Public Health, 60 College St, Room 428, PO Box 208034, 06520-8034, New Haven, CT, USA aut NATIONALLICENCE 700 1- Irwin Melinda Department of Chronic Disease Epidemiology, Yale School of Public Health, 60 College St, Room 428, PO Box 208034, 06520-8034, New Haven, CT, USA aut NATIONALLICENCE 700 1- Zhou Yang Department of Chronic Disease Epidemiology, Yale School of Public Health, 60 College St, Room 428, PO Box 208034, 06520-8034, New Haven, CT, USA aut NATIONALLICENCE 700 1- Lu Lingeng Department of Chronic Disease Epidemiology, Yale School of Public Health, 60 College St, Room 428, PO Box 208034, 06520-8034, New Haven, CT, USA aut NATIONALLICENCE 700 1- Risch Harvey Department of Chronic Disease Epidemiology, Yale School of Public Health, 60 College St, Room 428, PO Box 208034, 06520-8034, New Haven, CT, USA aut NATIONALLICENCE 700 1- Yu Herbert Department of Chronic Disease Epidemiology, Yale School of Public Health, 60 College St, Room 428, PO Box 208034, 06520-8034, New Haven, CT, USA aut NATIONALLICENCE 773 0- Cancer Causes & Control Springer Netherlands 22/2(2011-02-01), 219-226 0957-5243 22:2<219 2011 22 10552 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer