caa a22 4500 44531608X CHVBK 20180317142647.0 cr unu---uuuuu 170323e20110201xx s 000 0 eng 10.1007/s10552-010-9691-6 doi (NATIONALLICENCE)springer-10.1007/s10552-010-9691-6 Modifiable risk factors for prostate cancer mortality in London: forty years of follow-up in the Whitehall study [Elektronische Daten] [G. Batty, Mika Kivimäki, Robert Clarke, George Davey Smith, Martin Shipley] Background: The determinants of prostate cancer--aside from established but non-modifiable risk factors of increased age, black ethnicity, and a positive family history--are poorly understood. Methods: We examined the association of a series of baseline socioeconomic, behavioral, and metabolic characteristics with the risk of prostate cancer mortality in a 40-year follow-up of study members from the original Whitehall cohort study. During this period there were 578 prostate cancer deaths in 17,934 men. Results: After adjustment for a series of baseline covariates, results from proportional hazards regression analyses indicated that marital status (hazard ratio; 95% confidence interval: widowed/divorced vs. married: 1.44; 0.95, 2.18), raised blood cholesterol (tertile 3 vs. 1: 1.35; 1.11, 1.65), and increased physical stature (tertile 3 vs. 1: 1.37; 1.09, 1.74) were associated with death from prostate cancer, although statistical significance at conventional levels was not apparent in all analyses. There was no evidence that physical activity, smoking habit, socio-economic status, component of either blood pressure or diabetes predicted the risk of death from this malignancy herein. Conclusions: In the present study, there was a suggestion that marital status, blood cholesterol, and height were risk indices for death from prostate cancer. Springer Science+Business Media B.V., 2010 Epidemiology nationallicence Risk factors nationallicence Prostate cancer nationallicence Batty G. Department of Epidemiology and Public Health, University College London, 1-19 Torrington Place, WC1E 6BT, London, UK aut Kivimäki Mika Department of Epidemiology and Public Health, University College London, 1-19 Torrington Place, WC1E 6BT, London, UK aut Clarke Robert Clinical Trial Service Unit and Epidemiological Studies Unit, University of Oxford, Oxford, UK aut Davey Smith George Department of Social Medicine, University of Bristol, Bristol, UK aut Shipley Martin Department of Epidemiology and Public Health, University College London, 1-19 Torrington Place, WC1E 6BT, London, UK aut Cancer Causes & Control Springer Netherlands 22/2(2011-02-01), 311-318 0957-5243 22:2<311 2011 22 10552 https://doi.org/10.1007/s10552-010-9691-6 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10552-010-9691-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Batty G. Department of Epidemiology and Public Health, University College London, 1-19 Torrington Place, WC1E 6BT, London, UK aut NATIONALLICENCE 700 1- Kivimäki Mika Department of Epidemiology and Public Health, University College London, 1-19 Torrington Place, WC1E 6BT, London, UK aut NATIONALLICENCE 700 1- Clarke Robert Clinical Trial Service Unit and Epidemiological Studies Unit, University of Oxford, Oxford, UK aut NATIONALLICENCE 700 1- Davey Smith George Department of Social Medicine, University of Bristol, Bristol, UK aut NATIONALLICENCE 700 1- Shipley Martin Department of Epidemiology and Public Health, University College London, 1-19 Torrington Place, WC1E 6BT, London, UK aut NATIONALLICENCE 773 0- Cancer Causes & Control Springer Netherlands 22/2(2011-02-01), 311-318 0957-5243 22:2<311 2011 22 10552 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer