caa a22 4500 445316128 CHVBK 20180317142647.0 cr unu---uuuuu 170323e20110201xx s 000 0 eng 10.1007/s10552-010-9686-3 doi (NATIONALLICENCE)springer-10.1007/s10552-010-9686-3 Diabetes and risk of pancreatic cancer: a pooled analysis of three large case-control studies [Elektronische Daten] [Donghui Li, Hongwei Tang, Manal Hassan, Elizabeth Holly, Paige Bracci, Debra Silverman] Racial differences in diabetes-associated pancreatic cancer (PC) and the interaction of diabetes with other risk factors are not well established. We determined the association between diabetes and risk of PC in 2,192 cases and 5,113 controls in three large case-control studies conducted at the National Cancer Institute, the University of California San Francisco, and the M.D. Anderson Cancer Center. In multivariable analyses, diabetes was associated with a 1.8-fold risk of PC [95% confidence interval (CI)=1.5-2.1]. Risk estimates decreased with increasing years with diabetes (≤2years OR=2.9, 95% CI=2.1-3.9; 3-5years OR=1.9, 95% CI=1.3-2.6; 6-10years OR=1.6, 95% CI=1.2-2.3; 11-15years OR=1.3, 95% CI=0.9-2.0;>15years OR=1.4, 95% CI=1.0-2.0 (p for trend<0.0001). Among diabetics, risk was higher in insulin ever users compared with nonusers (OR=2.2, 95% CI=1.6-3.7) and was restricted to insulin use of≤3years (OR=2.4). Insulin use of>10years was associated with a reduced risk of pancreatic cancer (OR=0.5, 95% CI=0.3-0.9; p for trend<0.0001). Hispanic men and Asians had a higher risk of diabetes-associated PC than did whites and blacks, but the differences were not statistically significant. No significant interaction between diabetes and cigarette smoking, alcohol consumption and body mass index was observed. Although reverse causation may explain the association between diabetes diagnosed in close temporal proximity to PC, our results show that long-term diabetes, even though risk diminishes over time, remains a risk factor for PC independent of obesity and smoking. Springer Science+Business Media B.V., 2010 Diabetes nationallicence Pancreatic cancer nationallicence Case-control study nationallicence Epidemiology nationallicence AOR : Adjusted odds ratio nationallicence BMI : Body mass index nationallicence CI : Confidence interval nationallicence HCFA : Health Care Finance Administration nationallicence MDACC : The University of Texas M.D. Anderson Cancer Center nationallicence NCI : National Cancer Institute nationallicence OR : Odds ratio nationallicence PC : Pancreatic cancer nationallicence SFBA : The University of California San Francisco Bay Area nationallicence Li Donghui Department of Gastrointestinal Medical Oncology, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 426, 77030, Houston, TX, USA aut Tang Hongwei Department of Gastrointestinal Medical Oncology, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 426, 77030, Houston, TX, USA aut Hassan Manal Department of Gastrointestinal Medical Oncology, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 426, 77030, Houston, TX, USA aut Holly Elizabeth Department of Epidemiology and Biostatistics, School of Medicine, University of California San Francisco, San Francisco, CA, USA aut Bracci Paige Department of Epidemiology and Biostatistics, School of Medicine, University of California San Francisco, San Francisco, CA, USA aut Silverman Debra Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA aut Cancer Causes & Control Springer Netherlands 22/2(2011-02-01), 189-197 0957-5243 22:2<189 2011 22 10552 https://doi.org/10.1007/s10552-010-9686-3 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10552-010-9686-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Li Donghui Department of Gastrointestinal Medical Oncology, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 426, 77030, Houston, TX, USA aut NATIONALLICENCE 700 1- Tang Hongwei Department of Gastrointestinal Medical Oncology, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 426, 77030, Houston, TX, USA aut NATIONALLICENCE 700 1- Hassan Manal Department of Gastrointestinal Medical Oncology, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 426, 77030, Houston, TX, USA aut NATIONALLICENCE 700 1- Holly Elizabeth Department of Epidemiology and Biostatistics, School of Medicine, University of California San Francisco, San Francisco, CA, USA aut NATIONALLICENCE 700 1- Bracci Paige Department of Epidemiology and Biostatistics, School of Medicine, University of California San Francisco, San Francisco, CA, USA aut NATIONALLICENCE 700 1- Silverman Debra Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA aut NATIONALLICENCE 773 0- Cancer Causes & Control Springer Netherlands 22/2(2011-02-01), 189-197 0957-5243 22:2<189 2011 22 10552 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer