caa a22 4500 445316144 CHVBK 20180317142647.0 cr unu---uuuuu 170323e20111101xx s 000 0 eng 10.1007/s10552-011-9835-3 doi (NATIONALLICENCE)springer-10.1007/s10552-011-9835-3 Associations of pregnancy characteristics with maternal and cord steroid hormones, angiogenic factors, and insulin-like growth factor axis [Elektronische Daten] [Jessica Faupel-Badger, Yuping Wang, S. Karumanchi, Frank Stanczyk, Michael Pollak, Thomas McElrath, Robert Hoover, Rebecca Troisi] Background: The objective of this study was to comprehensively profile biological factors in pregnancy that have been postulated to be important components of the in utero environment and may also have relevance to later susceptibility to cancer and other chronic diseases. Methods: Steroid sex hormones, IGFs, and angiogenic factors were measured in maternal and cord serum from term normotensive pregnancies. Spearman correlations and linear regression estimated relationships among the biological factors and clinical characteristics. Results: The analytes were generally not correlated between maternal and fetal circulations. However, significant correlations were demonstrated among several analytes within maternal or cord samples. A few analytes were associated with clinical characteristics (e.g., maternal IGF-1 and IGFBP-3 were inversely correlated with offspring birth weight, while maternal leptin and cord testosterone were positively correlated with this characteristic). Maternal androgens were higher in African-Americans than whites, and maternal PlGF and soluble fms-like tyrosine kinase-1 (sFlt-1) were higher in male than female offspring. Conclusions: There were significant correlations among analytes, but the patterns differed depending on whether they were measured in the maternal or fetal circulation. The number and magnitude of correlations among analytes, however, should affect the design and interpretation of future studies. Springer Science+Business Media B.V. (outside the USA), 2011 African-American nationallicence Angiogenic factors nationallicence IGF nationallicence Leptin nationallicence Prolactin nationallicence Faupel-Badger Jessica Cancer Prevention Fellowship Program, Center for Cancer Training, National Cancer Institute, 6120 Executive Blvd (EPS), Suite 150E, MSC 7105, 20892-7105, Bethesda, MD, USA aut Wang Yuping Department of Obstetrics and Gynecology, Louisiana State University Health Sciences Center, Shreveport, LA, USA aut Karumanchi S. Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA aut Stanczyk Frank Departments of Obstetrics and Gynecology, and Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA, USA aut Pollak Michael Department of Medicine, McGill University, Montreal, Canada aut McElrath Thomas Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA aut Hoover Robert Epidemiology and Biostatistics Program, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA aut Troisi Rebecca Epidemiology and Biostatistics Program, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA aut Cancer Causes & Control Springer Netherlands 22/11(2011-11-01), 1587-1595 0957-5243 22:11<1587 2011 22 10552 https://doi.org/10.1007/s10552-011-9835-3 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10552-011-9835-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Faupel-Badger Jessica Cancer Prevention Fellowship Program, Center for Cancer Training, National Cancer Institute, 6120 Executive Blvd (EPS), Suite 150E, MSC 7105, 20892-7105, Bethesda, MD, USA aut NATIONALLICENCE 700 1- Wang Yuping Department of Obstetrics and Gynecology, Louisiana State University Health Sciences Center, Shreveport, LA, USA aut NATIONALLICENCE 700 1- Karumanchi S. Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA aut NATIONALLICENCE 700 1- Stanczyk Frank Departments of Obstetrics and Gynecology, and Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA, USA aut NATIONALLICENCE 700 1- Pollak Michael Department of Medicine, McGill University, Montreal, Canada aut NATIONALLICENCE 700 1- McElrath Thomas Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA aut NATIONALLICENCE 700 1- Hoover Robert Epidemiology and Biostatistics Program, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA aut NATIONALLICENCE 700 1- Troisi Rebecca Epidemiology and Biostatistics Program, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA aut NATIONALLICENCE 773 0- Cancer Causes & Control Springer Netherlands 22/11(2011-11-01), 1587-1595 0957-5243 22:11<1587 2011 22 10552 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer