caa a22 4500 445316160 CHVBK 20180317142648.0 cr unu---uuuuu 170323e20111101xx s 000 0 eng 10.1007/s10552-011-9831-7 doi (NATIONALLICENCE)springer-10.1007/s10552-011-9831-7 Serum total and HDL cholesterol and risk of prostate cancer [Elektronische Daten] [Alison Mondul, Stephanie Weinstein, Jarmo Virtamo, Demetrius Albanes] Background: Studies suggest a decreased risk of high-grade prostate cancer in men with lower circulating total cholesterol and that statins may protect against aggressive disease. Confirmation in additional populations and examination of associations for lipoprotein subfractions are needed. Methods: We examined prostate cancer risk and serum total and HDL cholesterol in the ATBC Study cohort (n=29,093). Cox proportional hazards models were used to estimate the relative risk of total (n=2,041), non-aggressive (n=829), aggressive (n=461), advanced (n=412), and high-grade (n=231) prostate cancer by categories of total and HDL cholesterol. Results: After excluding the first 10years of follow-up, men with higher serum total cholesterol were at increased risk of overall (≥240 vs. <200mg/dl: HR=1.22, 95% CI 1.03-1.44, p-trend=0.01) and advanced (≥240 vs. <200mg/dl: HR=1.85, 95% CI 1.13-3.03, p-trend=0.05) prostate cancer. Higher HDL cholesterol was suggestively associated with a decreased risk of prostate cancer regardless of stage or grade. Conclusions: In this population of smokers, high serum total cholesterol was associated with higher risk of advanced prostate cancer, and high HDL cholesterol suggestively reduced the risk of prostate cancer overall. These results support previous studies and, indirectly, support the hypothesis that statins may reduce the risk of advanced prostate cancer by lowering cholesterol. Springer Science+Business Media B.V. (outside the USA), 2011 Cholesterol nationallicence HDL nationallicence Prospective studies nationallicence Prostatic neoplasms nationallicence Epidemiology nationallicence Risk nationallicence Molecular nationallicence Biomarker nationallicence Mondul Alison Department of Health and Human Services, Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, 6120 Executive Blvd. Ste. 320, 20852, Rockville, MD, USA aut Weinstein Stephanie Department of Health and Human Services, Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, 6120 Executive Blvd. Ste. 320, 20852, Rockville, MD, USA aut Virtamo Jarmo Department of Chronic Disease Prevention, National Institute for Health and Welfare, P.O. Box 30, 00271, Helsinki, Finland aut Albanes Demetrius Department of Health and Human Services, Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, 6120 Executive Blvd. Ste. 320, 20852, Rockville, MD, USA aut Cancer Causes & Control Springer Netherlands 22/11(2011-11-01), 1545-1552 0957-5243 22:11<1545 2011 22 10552 https://doi.org/10.1007/s10552-011-9831-7 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10552-011-9831-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Mondul Alison Department of Health and Human Services, Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, 6120 Executive Blvd. Ste. 320, 20852, Rockville, MD, USA aut NATIONALLICENCE 700 1- Weinstein Stephanie Department of Health and Human Services, Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, 6120 Executive Blvd. Ste. 320, 20852, Rockville, MD, USA aut NATIONALLICENCE 700 1- Virtamo Jarmo Department of Chronic Disease Prevention, National Institute for Health and Welfare, P.O. Box 30, 00271, Helsinki, Finland aut NATIONALLICENCE 700 1- Albanes Demetrius Department of Health and Human Services, Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, 6120 Executive Blvd. Ste. 320, 20852, Rockville, MD, USA aut NATIONALLICENCE 773 0- Cancer Causes & Control Springer Netherlands 22/11(2011-11-01), 1545-1552 0957-5243 22:11<1545 2011 22 10552 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer