caa a22 4500 445316195 CHVBK 20180317142648.0 cr unu---uuuuu 170323e20111101xx s 000 0 eng 10.1007/s10552-011-9822-8 doi (NATIONALLICENCE)springer-10.1007/s10552-011-9822-8 Associations of serum vitamin A and carotenoid levels with markers of prostate cancer detection among US men [Elektronische Daten] [Hind Beydoun, Monal Shroff, Ravinder Mohan, May Beydoun] Associations of serum vitamin A and carotenoid levels with markers of prostate cancer detection were evaluated among 3,927 US men, 40-85years of age, who participated in the 2001-2006 National Health and Nutrition Examination Surveys. Five recommended definitions of prostate cancer detection were adopted using total and free prostate-specific antigen (tPSA and fPSA) laboratory measurements. Men were identified as high risk based on alternative cutoffs, namely tPSA>10ng/ml, tPSA>4ng/ml, tPSA>2.5ng/ml, %fPSA<25%, and %fPSA<15%. %fPSA was defined as (fPSA÷tPSA)× 100%. Serum levels of vitamin A (retinol and retinyl esters) and carotenoids (α-carotene, β-carotene, β-cryptoxanthin, lutein+zeaxanthin, lycopene) were defined as quartiles and examined as risk/protective factors for PSA biomarkers. Odds ratios (OR) and 95% confidence intervals (CI) were estimated using binary logistic models. After adjustment for known demographic, socioeconomic, and lifestyle confounders, high serum levels of retinyl esters (tPSA>10ng/ml: Q4 vs. Q1→OR=0.38, 95% CI: 0.14-1.00) and α-carotene (%fPSA<15%: Q4 vs. Q1→OR=0.49, 95% CI: 0.32-0.76) were associated with a lower odds, whereas high serum level of lycopene (tPSA>2.5ng/ml: Q4 vs. Q1→OR=1.49, 95% CI: 1.01-2.14) was associated with a greater odds of prostate cancer detection. Apart from the three significant associations observed, no other exposure-outcome association was significant. Monitoring specific antioxidant levels may be helpful in the early detection of prostate cancer. Springer Science+Business Media B.V., 2011 Vitamin A nationallicence Carotenoids nationallicence Prostate cancer nationallicence Prostate-specific antigen nationallicence BMI : Body mass index nationallicence CI : Confidence interval nationallicence DRE : Digital rectal exam nationallicence fPSA : Free prostate-specific antigen nationallicence %fPSA : Percent free prostate-specific antigen nationallicence Q1 : First quartile nationallicence Q2 : Second quartile nationallicence Q3 : Third quartile nationallicence Q4 : Fourth quartile nationallicence NHANES : National Health and Nutrition Examination Survey nationallicence OR : Odds ratio nationallicence PCa : Prostate cancer nationallicence PSA : Prostate-specific antigen nationallicence ROS : Reactive oxygen species nationallicence tPSA : Total prostate-specific antigen nationallicence Beydoun Hind Graduate Program in Public Health, Eastern Virginia Medical School, 700 W. Olney Rd, Post Office Box 1980, 23501-1980, Norfolk, VA, USA aut Shroff Monal Department of Epidemiology, University of Michigan, Ann Arbor, MI, USA aut Mohan Ravinder Department of Family Medicine, Eastern Virginia Medical School, Norfolk, VA, USA aut Beydoun May NIH/Intramural Research Program, National Institute on Aging, Baltimore, MD, USA aut Cancer Causes & Control Springer Netherlands 22/11(2011-11-01), 1483-1495 0957-5243 22:11<1483 2011 22 10552 https://doi.org/10.1007/s10552-011-9822-8 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10552-011-9822-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Beydoun Hind Graduate Program in Public Health, Eastern Virginia Medical School, 700 W. Olney Rd, Post Office Box 1980, 23501-1980, Norfolk, VA, USA aut NATIONALLICENCE 700 1- Shroff Monal Department of Epidemiology, University of Michigan, Ann Arbor, MI, USA aut NATIONALLICENCE 700 1- Mohan Ravinder Department of Family Medicine, Eastern Virginia Medical School, Norfolk, VA, USA aut NATIONALLICENCE 700 1- Beydoun May NIH/Intramural Research Program, National Institute on Aging, Baltimore, MD, USA aut NATIONALLICENCE 773 0- Cancer Causes & Control Springer Netherlands 22/11(2011-11-01), 1483-1495 0957-5243 22:11<1483 2011 22 10552 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer